BDgene

Study Report

Basic Info
Reference
Citation Mansour, H. A., M. E. Talkowski, et al. (2009). Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord 11(7): 701-710.
Disease Type Bipolar I Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 523 patients with BPI, 527 with SZ ?SZA (314 SZ and 213 SZA) and 477 control individuals
SNP/Region/Marker Size 276 SNPs
Predominant Ethnicity Caucasian
Population American
Gender male/female:225/298 in patients with BPI,340/187 in patients with SZ ?SZA;229/248 in control individuals
Age Group mean age(year):43.11(SD=12.71) in patients with BPI, 37.31(SD=10.12) in patients with SZ ?SZA, 46.44(SD=16.72) in control individuals

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 15)

Genes reported by this study for BD (count: 21)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs10217594 RORB Single SNP-based analyses:Trends test P-value = 0.313 in SZ No significant association was observed Negative
SZ rs10462021 PER3 Single SNP-based analyses:Trends test P-value = 0.036 in SZ Significant association was observed Positive
SZ rs17025005 NPAS2 Single SNP-based analyses:Trends test P-value = 0.085 in SZ No significant association was observed Negative
SZ rs17691363 RORB Single SNP-based analyses:Trends test P-value = 0.983 in SZ No significant association was observed Negative
SZ rs1996147 EGR3 Single SNP-based analyses:Trends test P-value = 0.193 in SZ No significant association was observed Negative
SZ rs1997644 CSNK1E Single SNP-based analyses:Trends test P-value = 0.363 in SZ No significant association was observed Negative
SZ rs10491929 RORB Single SNP-based analyses:Trends test P-value = 0.023 in SZ Significant association was observed Positive
SZ rs11123857 NPAS2 Single SNP-based analyses:Trends test P-value = 0.038 in SZ Significant association was observed Positive
SZ rs13025524 NPAS2 Single SNP-based analyses:Trends test P-value = 0.025 in SZ Significant association was observed Positive
SZ rs1554338 CRY2 MAPK8IP1 Single SNP-based analyses:Trends test P-value = 0.411 in SZ No significant association was observed Negative
SZ rs7126303 ARNTL RN7SKP151 Single SNP-based analyses:Trends test P-value = 0.738 in SZ No significant association was observed Negative
SZ rs2304674 PER2 Single SNP-based analyses:Trends test P-value = 0.033 in SZ Significant association was observed Positive
SZ rs2304672 PER2 Single SNP-based analyses:Trends test P-value = 0.048 in SZ Significant association was observed Positive
SZ rs6543004 NPAS2 Single SNP-based analyses:Trends test P-value = 0.024 in SZ Significant association was observed Positive
SZ rs2640909 PER3 Single SNP-based analyses:Trends test P-value = 0.031 in SZ Significant association was observed Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ CSNK1E Gene-based tests:X<sup>2</sup>=3.815, P-value = 0.347 in dominant model in SZ/SZA, X<sup>2</sup>=2.768, P-value = 0.564 in recessive model in SZ/SZA, X<sup>2</sup>=1.423, P-value = 0.814 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ PER2 Gene-based tests:X<sup>2</sup>=6.944, P-value = 0.068 in recessive model in SZ/SZA, X<sup>2</sup>=4.563, P-value = 0.209 in additive model in SZ/SZA, X<sup>2</sup>=1.671, P-value = 0.769 in dominant model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA. Positive
SZ CLOCK Gene-based tests:X<sup>2</sup>=1.83, P-value = 0.708 in additive model in SZ/SZA, X<sup>2</sup>=2.214, P-value = 0.73 in dominant model in SZ/SZA, X<sup>2</sup>=1.351, P-value = 0.908 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ ARNTL2 Gene-based tests:X<sup>2</sup>=6.36, P-value = 0.196 in dominant model in SZ/SZA, X<sup>2</sup>=4.7, P-value = 0.434 in recessive model in SZ/SZA, X<sup>2</sup>=3.236, P-value = 0.678 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ CSNK1D Gene-based tests:X<sup>2</sup>=2.253, P-value = 0.137 in additive model in SZ/SZA, X<sup>2</sup>=2.015, P-value = 0.173 in dominant model in SZ/SZA, X<sup>2</sup>=0.733, P-value = 0.425 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ DBP Gene-based tests:X<sup>2</sup>=2.864, P-value = 0.173 in dominant model in SZ/SZA, X<sup>2</sup>=2.134, P-value = 0.251 in recessive model in SZ/SZA, X<sup>2</sup>=1.57, P-value = 0.371 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ CNR1 Gene-based tests:X<sup>2</sup>=3.898, P-value = 0.389 in additive model in SZ/SZA, X<sup>2</sup>=4.189, P-value = 0.404 in dominant model in SZ/SZA, X<sup>2</sup>=1.603, P-value = 0.957 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ PER1 Gene-based tests:X<sup>2</sup>=1.525, P-value = 0.481 in recessive model in SZ/SZA, X<sup>2</sup>=0.596, P-value = 0.64 in dominant model in SZ/SZA, X<sup>2</sup>=0.389, P-value = 0.725 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ BHLHE41 Gene-based tests:X<sup>2</sup>=0.6, P-value = 0.829 in recessive model in SZ/SZA, X<sup>2</sup>=0.282, P-value = 0.94 in dominant model in SZ/SZA, X<sup>2</sup>=0.1, P-value = 0.985 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ PER3 Gene-based tests:X<sup>2</sup>=4.723, P-value = 0.245 in additive model in SZ/SZA, X<sup>2</sup>=4.379, P-value = 0.319 in dominant model in SZ/SZA, X<sup>2</sup>=4.42, P-value = 0.349 in recessive model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA. Positive
SZ NPAS2 Gene-based tests:X<sup>2</sup>=11.321, P-value = 0.034 in recessive model in SZ/SZA, X<sup>2</sup>=7.892, P-value = 0.205 in dominant model in SZ/SZA, X<sup>2</sup>=5.146, P-value = 0.558 in additive model in SZ/SZA. Nominally significant associations were also noted with the SZ /SZA sample at NPAS2 under a recessive model.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA. Positive
SZ ARNTL Gene-based tests:X<sup>2</sup>=3.334, P-value = 0.621 in additive model in SZ/SZA, X<sup>2</sup>=2.424, P-value = 0.882 in recessive model in SZ/SZA, X<sup>2</sup>=2.346, P-value = 0.913 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ CSNK2A1 Gene-based tests:X<sup>2</sup>=3.126, P-value = 0.381 in recessive model in SZ/SZA, X<sup>2</sup>=2.752, P-value = 0.47 in dominant model in SZ/SZA, X<sup>2</sup>=1.354, P-value = 0.719 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ RORB Gene-based tests:X<sup>2</sup>=9.945, P-value = 0.056 in dominant model in SZ/SZA, X<sup>2</sup>=5.51, P-value = 0.407 in additive model in SZ/SZA, X<sup>2</sup>=4.505, P-value = 0.699 in recessive model in SZ/SZA.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA. Positive
SZ NR1D1 Gene-based tests:X<sup>2</sup>=4.633, P-value = 0.182 in recessive model in SZ/SZA, X<sup>2</sup>=2.144, P-value = 0.543 in dominant model in SZ/SZA, X<sup>2</sup>=0.572, P-value = 0.945 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ TIMELESS Gene-based tests:X<sup>2</sup>=3.823, P-value = 0.21 in recessive model in SZ/SZA, X<sup>2</sup>=3.599, P-value = 0.22 in additive model in SZ/SZA, X<sup>2</sup>=3.378, P-value = 0.298 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ AANAT Gene-based tests:X<sup>2</sup>=3.101, P-value = 0.268 in additive model in SZ/SZA, X<sup>2</sup>=2.817, P-value = 0.34 in dominant model in SZ/SZA, X<sup>2</sup>=2.747, P-value = 0.345 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ NFIL3 Gene-based tests:X<sup>2</sup>=4.24, P-value = 0.276 in dominant model in SZ/SZA, X<sup>2</sup>=3.605, P-value = 0.369 in recessive model in SZ/SZA, X<sup>2</sup>=3.128, P-value = 0.438 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ CRY2 Gene-based tests:X<sup>2</sup>=1.267, P-value = 0.767 in additive model in SZ/SZA, X<sup>2</sup>=1.576, P-value = 0.788 in recessive model in SZ/SZA, X<sup>2</sup>=0.701, P-value = 0.954 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ EGR3 Gene-based tests:X<sup>2</sup>=1.294, P-value = 0.469 in recessive model in SZ/SZA, X<sup>2</sup>=1.601, P-value = 0.495 in additive model in SZ/SZA, X<sup>2</sup>=0.774, P-value = 0.759 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative
SZ TIPIN Gene-based tests:X<sup>2</sup>=5.296, P-value = 0.108 in recessive model in SZ/SZA, X<sup>2</sup>=3.515, P-value = 0.237 in additive model in SZ/SZA, X<sup>2</sup>=3.622, P-value = 0.319 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. Negative