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Comment on Study | View All Comments on Study |
Reference | Mansour, H. A.,2009 PMID: 19839995 |
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Citation | Mansour, H. A., M. E. Talkowski, et al. (2009). Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord 11(7): 701-710. |
Disease Type | Bipolar I Disorder & Schizophrenia |
Study Design | case-control |
Study Type | Candidate-gene association study |
Sample Size | 523 patients with BPI, 527 with SZ ?SZA (314 SZ and 213 SZA) and 477 control individuals |
SNP/Region/Marker Size | 276 SNPs |
Predominant Ethnicity | Caucasian |
Population | American |
Gender | male/female:225/298 in patients with BPI,340/187 in patients with SZ ?SZA;229/248 in control individuals |
Age Group | mean age(year):43.11(SD=12.71) in patients with BPI, 37.31(SD=10.12) in patients with SZ ?SZA, 46.44(SD=16.72) in control individuals |
Sample Diagnosis | DSM |
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Sample Status | Genomic DNA samples were obtained from BPI patients recruited through the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).Unrelated patients with SZ or SZA (according to DSM-IV criteria) were recruited at Western Psychiatric Institute and Clinic,Pittsburgh, PA, USA, and surrounding regions(N = 527; n = 314 SZ and n = 213 SZA).Two sets of adult controls screened for absence of psychosis or BPI were included: a Pittsburgh-based sample(n = 168) and a national sample available from the NIMH-GRI(n = 309). |
Technique | genotyping |
Statistical Method | LD was analyzed using Hclust software to select tag SNPs. Gene-based tests were conducted initially to test for associations, followed by tests with individual SNPs. For gene-based analyses, we used the (T-max) test of association fitting additive,dominant, and recessive models for each gene.SNP-based association analyses for the diagnostic phenotype were conducted using the Cochran-Armitage trend test. |
Result Summary | RESULTS: Using gene-based tests, suggestive associations were noted between EGR3 and BPI (p = 0.017), and between NPAS2 and SZ/SZA (p = 0.034). Three SNPs were associated with both sets of disorders (NPAS2: rs13025524 and rs11123857; RORB: rs10491929; p < 0.05). None of the associations remained significant following corrections for multiple comparisons. Approximately 15% of the analyzed SNPs overlapped with an independent study that conducted GWAS for BPI; suggestive overlap between the GWAS analyses and ours was noted at ARNTL. CONCLUSIONS: Several suggestive, novel associations were detected with circadian genes and BPI and SZ/SZA, but the present analyses do not support associations with common polymorphisms that confer risk with odds ratios greater than 1.5. Additional analyses using adequately powered samples are warranted to further evaluate these results. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
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rs10217594 | RORB | A/G | Single SNP-based analyses: Trends test P-value = 0.026 in BPI | Significant association was observed Significant association was observed | Positive | |
rs7126303 | ARNTL RN7SKP151 | A/G | Single SNP-based analyses: Trends test P-value = 0.04 in BPI | Significant association was observed Significant association was observed | Positive | |
rs6543004 | NPAS2 | A/T | Single SNP-based analyses: Trends test P-value = 0.139 in BPI | No significant association was observed No significant association was observed | Negative | |
rs2304672 | PER2 | C/G | Single SNP-based analyses: Trends test P-value = 0.342 in BPI | No significant association was observed No significant association was observed | Negative | |
rs1997644 | CSNK1E | A/G | Single SNP-based analyses: Trends test P-value = 0.024 in BPI | Significant association was observed Significant association was observed | Positive | |
rs2640909 | PER3 | Single SNP-based analyses: Trends test P-value = 0.421 in BPI | No significant association was observed No significant association was observed | Negative | ||
rs2304674 | PER2 | A/G | Single SNP-based analyses: Trends test P-value = 0.051 in BPI | No significant association was observed No significant association was observed | Negative | |
rs17025005 | NPAS2 | A/G | Single SNP-based analyses: Trends test P-value = 0.009 in BPI | Significant association was observed Significant association was observed | Positive | |
rs1554338 | CRY2 MAPK8IP1 | A/G | Single SNP-based analyses: Trends test P-value = 0.031 in BPI | Significant association was observed Significant association was observed | Positive | |
rs1996147 | EGR3 | A/G | Single SNP-based analyses: Trends test P-value = 0.006 in BPI | Significant association was observed Significant association was observed | Positive | |
rs17691363 | RORB | A/G | Single SNP-based analyses: Trends test P-value = 0.035 in BPI | Significant association was observed Significant association was observed | Positive | |
rs10491929 | RORB | A/G | Single SNP-based analyses: Trends test P-value = 0.023 in BPI | Significant association was observed Significant association was observed | Positive | |
rs10462021 | PER3 | Single SNP-based analyses: Trends test P-value = 0.334 in BPI | No significant association was observed No significant association was observed | Negative | ||
rs13025524 | NPAS2 | A/G | Single SNP-based analyses: Trends test P-value = 0.016 in BPI | Significant association was observed Significant association was observed | Positive | |
rs11123857 | NPAS2 | A/G | Single SNP-based analyses: Trends test P-value = 0.036 in BPI | Significant association was observed Significant association was observed | Positive |
Gene | Statistical Values/Author Comments | Result Category |
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NPAS2 | Gene-based tests:X<sup>2</sup>=6.629, P-value = 0.326 in additive model, X<sup>2</sup>=5.686, P-value = 0.553 in dominant model, X<sup>2</sup>=5.077, P-value = 0.701 in recessive model in BPI. Significant association was observed using single SNP-based analyses while no association was observ...... Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More... | Positive |
AANAT | Gene-based tests:X<sup>2</sup>=1.997, P-value = 0.482 in additive model, X<sup>2</sup>=1.811, P-value = 0.538 in dominant model, X<sup>2</sup>=1.818, P-value = 0.55 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
CLOCK | Gene-based tests:X<sup>2</sup>=5.096, P-value = 0.142 in dominant model, X<sup>2</sup>=3.578, P-value = 0.434 in recessive model, X<sup>2</sup>=2.556, P-value = 0.524 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
RORB | Gene-based tests:X<sup>2</sup>=7.436, P-value = 0.203 in recessive model, X<sup>2</sup>=5.403, P-value = 0.475 in dominant model, X<sup>2</sup>=4.907, P-value = 0.5 in additive model in BPI. Significant association was observed using single SNP-based analyses while no association was observ...... Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More... | Positive |
PER3 | Gene-based tests:X<sup>2</sup>=3.663, P-value = 0.487 in recessive model, X<sup>2</sup>=2.145, P-value = 0.784 in dominant model, X<sup>2</sup>=1.5, P-value = 0.847 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
NR1D1 | Gene-based tests:X<sup>2</sup>=2.973, P-value = 0.385 in dominant model, X<sup>2</sup>=3.107, P-value = 0.409 in recessive model, X<sup>2</sup>=2.316, P-value = 0.456 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
ARNTL | Gene-based tests:X<sup>2</sup>=4.293, P-value = 0.422 in additive model, X<sup>2</sup>=4.05, P-value = 0.566 in dominant model, X<sup>2</sup>=2.854, P-value = 0.8 in recessive model in BPI. Association was observed using single SNP-based analyses while no association was observed using gen...... Association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More... | Positive |
BHLHE41 | Gene-based tests:X<sup>2</sup>=0.786, P-value = 0.708 in additive model, X<sup>2</sup>=0.86, P-value = 0.717 in dominant model, X<sup>2</sup>=0.471, P-value = 0.868 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
EGR3 | Gene-based tests:X<sup>2</sup>=7.248, P-value = 0.014 in recessive model, X<sup>2</sup>=7.659, P-value = 0.02 in additive model, X<sup>2</sup>=2.613, P-value = 0.288 in dominant model in BPI. Significant association was observed using both single SNP-based analyses and gene-based tests in BP...... Significant association was observed using both single SNP-based analyses and gene-based tests in BPI. More... | Positive |
PER2 | Gene-based tests:X<sup>2</sup>=7.226, P-value = 0.062 in recessive model, X<sup>2</sup>=3.587, P-value = 0.336 in additive model, X<sup>2</sup>=1.828, P-value = 0.849 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
CRY2 | Gene-based tests:X<sup>2</sup>=5.443, P-value = 0.119 in recessive model, X<sup>2</sup>=4.967, P-value = 0.133 in additive model, X<sup>2</sup>=1.486, P-value = 0.768 in dominant model in BPI. Significant association was observed using single SNP-based analyses while no association was observ...... Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More... | Positive |
PER1 | Gene-based tests:X<sup>2</sup>=4.005, P-value = 0.111 in recessive model, X<sup>2</sup>=0.81, P-value = 0.544 in dominant model, X<sup>2</sup>=0.15, P-value = 0.893 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
ARNTL2 | Gene-based tests:X<sup>2</sup>=4.067, P-value = 0.559 in recessive model, X<sup>2</sup>=4.068, P-value = 0.591 in dominant model, X<sup>2</sup>=3.171, P-value = 0.699 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
CSNK1E | Gene-based tests:X<sup>2</sup>=6.251, P-value = 0.098 in recessive model, X<sup>2</sup>=5.354, P-value = 0.14 in additive model, X<sup>2</sup>=3.728, P-value = 0.354 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
CNR1 | Gene-based tests:X<sup>2</sup>=4.971, P-value = 0.304 in recessive model, X<sup>2</sup>=3.233, P-value = 0.623 in dominant model, X<sup>2</sup>=2.629, P-value = 0.643 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
DBP | Gene-based tests:X<sup>2</sup>=2.109, P-value = 0.273 in recessive model, X<sup>2</sup>=1.578, P-value = 0.377 in dominant model, X<sup>2</sup>=0.703, P-value = 0.632 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
CSNK1D | Gene-based tests:X<sup>2</sup>=3.077, P-value = 0.125 in recessive model, X<sup>2</sup>=0.286, P-value = 0.613 in additive model, X<sup>2</sup>=0.001, P-value = 1 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
TIMELESS | Gene-based tests:X<sup>2</sup>=3.072, P-value = 0.271 in recessive model, X<sup>2</sup>=0.332, P-value = 0.968 in additive model, X<sup>2</sup>=0.251, P-value = 0.993 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
CSNK2A1 | Gene-based tests:X<sup>2</sup>=5.274, P-value = 0.136 in dominant model, X<sup>2</sup>=2.372, P-value = 0.551 in recessive model, X<sup>2</sup>=1.527, P-value = 0.687 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
NFIL3 | Gene-based tests:X<sup>2</sup>=3.129, P-value = 0.448 in dominant model, X<sup>2</sup>=2.497, P-value = 0.575 in additive model, X<sup>2</sup>=2.136, P-value = 0.699 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
TIPIN | Gene-based tests:X<sup>2</sup>=4.334, P-value = 0.184 in dominant model, X<sup>2</sup>=3.796, P-value = 0.209 in additive model, X<sup>2</sup>=1.885, P-value = 0.608 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More... | Negative |
Disease | SNP | Related Gene(s) | Statistical Values | Description | Result Category |
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SZ | rs10217594 | RORB | Single SNP-based analyses:Trends test P-value = 0.313 in SZ | No significant association was observed | Negative |
SZ | rs10462021 | PER3 | Single SNP-based analyses:Trends test P-value = 0.036 in SZ | Significant association was observed | Positive |
SZ | rs17025005 | NPAS2 | Single SNP-based analyses:Trends test P-value = 0.085 in SZ | No significant association was observed | Negative |
SZ | rs17691363 | RORB | Single SNP-based analyses:Trends test P-value = 0.983 in SZ | No significant association was observed | Negative |
SZ | rs1996147 | EGR3 | Single SNP-based analyses:Trends test P-value = 0.193 in SZ | No significant association was observed | Negative |
SZ | rs1997644 | CSNK1E | Single SNP-based analyses:Trends test P-value = 0.363 in SZ | No significant association was observed | Negative |
SZ | rs10491929 | RORB | Single SNP-based analyses:Trends test P-value = 0.023 in SZ | Significant association was observed | Positive |
SZ | rs11123857 | NPAS2 | Single SNP-based analyses:Trends test P-value = 0.038 in SZ | Significant association was observed | Positive |
SZ | rs13025524 | NPAS2 | Single SNP-based analyses:Trends test P-value = 0.025 in SZ | Significant association was observed | Positive |
SZ | rs1554338 | CRY2 MAPK8IP1 | Single SNP-based analyses:Trends test P-value = 0.411 in SZ | No significant association was observed | Negative |
SZ | rs7126303 | ARNTL RN7SKP151 | Single SNP-based analyses:Trends test P-value = 0.738 in SZ | No significant association was observed | Negative |
SZ | rs2304674 | PER2 | Single SNP-based analyses:Trends test P-value = 0.033 in SZ | Significant association was observed | Positive |
SZ | rs2304672 | PER2 | Single SNP-based analyses:Trends test P-value = 0.048 in SZ | Significant association was observed | Positive |
SZ | rs6543004 | NPAS2 | Single SNP-based analyses:Trends test P-value = 0.024 in SZ | Significant association was observed | Positive |
SZ | rs2640909 | PER3 | Single SNP-based analyses:Trends test P-value = 0.031 in SZ | Significant association was observed | Positive |
Disease | Gene | Description | Result Category |
---|---|---|---|
SZ | CSNK1E | Gene-based tests:X<sup>2</sup>=3.815, P-value = 0.347 in dominant model in SZ/SZA, X<sup>2</sup>=2.768, P-value = 0.564 in recessive model in SZ/SZA, X<sup>2</sup>=1.423, P-value = 0.814 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | PER2 | Gene-based tests:X<sup>2</sup>=6.944, P-value = 0.068 in recessive model in SZ/SZA, X<sup>2</sup>=4.563, P-value = 0.209 in additive model in SZ/SZA, X<sup>2</sup>=1.671, P-value = 0.769 in dominant model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA. | Positive |
SZ | CLOCK | Gene-based tests:X<sup>2</sup>=1.83, P-value = 0.708 in additive model in SZ/SZA, X<sup>2</sup>=2.214, P-value = 0.73 in dominant model in SZ/SZA, X<sup>2</sup>=1.351, P-value = 0.908 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | ARNTL2 | Gene-based tests:X<sup>2</sup>=6.36, P-value = 0.196 in dominant model in SZ/SZA, X<sup>2</sup>=4.7, P-value = 0.434 in recessive model in SZ/SZA, X<sup>2</sup>=3.236, P-value = 0.678 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | CSNK1D | Gene-based tests:X<sup>2</sup>=2.253, P-value = 0.137 in additive model in SZ/SZA, X<sup>2</sup>=2.015, P-value = 0.173 in dominant model in SZ/SZA, X<sup>2</sup>=0.733, P-value = 0.425 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | DBP | Gene-based tests:X<sup>2</sup>=2.864, P-value = 0.173 in dominant model in SZ/SZA, X<sup>2</sup>=2.134, P-value = 0.251 in recessive model in SZ/SZA, X<sup>2</sup>=1.57, P-value = 0.371 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | CNR1 | Gene-based tests:X<sup>2</sup>=3.898, P-value = 0.389 in additive model in SZ/SZA, X<sup>2</sup>=4.189, P-value = 0.404 in dominant model in SZ/SZA, X<sup>2</sup>=1.603, P-value = 0.957 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | PER1 | Gene-based tests:X<sup>2</sup>=1.525, P-value = 0.481 in recessive model in SZ/SZA, X<sup>2</sup>=0.596, P-value = 0.64 in dominant model in SZ/SZA, X<sup>2</sup>=0.389, P-value = 0.725 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | BHLHE41 | Gene-based tests:X<sup>2</sup>=0.6, P-value = 0.829 in recessive model in SZ/SZA, X<sup>2</sup>=0.282, P-value = 0.94 in dominant model in SZ/SZA, X<sup>2</sup>=0.1, P-value = 0.985 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | PER3 | Gene-based tests:X<sup>2</sup>=4.723, P-value = 0.245 in additive model in SZ/SZA, X<sup>2</sup>=4.379, P-value = 0.319 in dominant model in SZ/SZA, X<sup>2</sup>=4.42, P-value = 0.349 in recessive model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA. | Positive |
SZ | NPAS2 | Gene-based tests:X<sup>2</sup>=11.321, P-value = 0.034 in recessive model in SZ/SZA, X<sup>2</sup>=7.892, P-value = 0.205 in dominant model in SZ/SZA, X<sup>2</sup>=5.146, P-value = 0.558 in additive model in SZ/SZA. Nominally significant associations were also noted with the SZ /SZA sample at NPAS2 under a recessive model.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA. | Positive |
SZ | ARNTL | Gene-based tests:X<sup>2</sup>=3.334, P-value = 0.621 in additive model in SZ/SZA, X<sup>2</sup>=2.424, P-value = 0.882 in recessive model in SZ/SZA, X<sup>2</sup>=2.346, P-value = 0.913 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | CSNK2A1 | Gene-based tests:X<sup>2</sup>=3.126, P-value = 0.381 in recessive model in SZ/SZA, X<sup>2</sup>=2.752, P-value = 0.47 in dominant model in SZ/SZA, X<sup>2</sup>=1.354, P-value = 0.719 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | RORB | Gene-based tests:X<sup>2</sup>=9.945, P-value = 0.056 in dominant model in SZ/SZA, X<sup>2</sup>=5.51, P-value = 0.407 in additive model in SZ/SZA, X<sup>2</sup>=4.505, P-value = 0.699 in recessive model in SZ/SZA.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA. | Positive |
SZ | NR1D1 | Gene-based tests:X<sup>2</sup>=4.633, P-value = 0.182 in recessive model in SZ/SZA, X<sup>2</sup>=2.144, P-value = 0.543 in dominant model in SZ/SZA, X<sup>2</sup>=0.572, P-value = 0.945 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | TIMELESS | Gene-based tests:X<sup>2</sup>=3.823, P-value = 0.21 in recessive model in SZ/SZA, X<sup>2</sup>=3.599, P-value = 0.22 in additive model in SZ/SZA, X<sup>2</sup>=3.378, P-value = 0.298 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | AANAT | Gene-based tests:X<sup>2</sup>=3.101, P-value = 0.268 in additive model in SZ/SZA, X<sup>2</sup>=2.817, P-value = 0.34 in dominant model in SZ/SZA, X<sup>2</sup>=2.747, P-value = 0.345 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | NFIL3 | Gene-based tests:X<sup>2</sup>=4.24, P-value = 0.276 in dominant model in SZ/SZA, X<sup>2</sup>=3.605, P-value = 0.369 in recessive model in SZ/SZA, X<sup>2</sup>=3.128, P-value = 0.438 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | CRY2 | Gene-based tests:X<sup>2</sup>=1.267, P-value = 0.767 in additive model in SZ/SZA, X<sup>2</sup>=1.576, P-value = 0.788 in recessive model in SZ/SZA, X<sup>2</sup>=0.701, P-value = 0.954 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | EGR3 | Gene-based tests:X<sup>2</sup>=1.294, P-value = 0.469 in recessive model in SZ/SZA, X<sup>2</sup>=1.601, P-value = 0.495 in additive model in SZ/SZA, X<sup>2</sup>=0.774, P-value = 0.759 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
SZ | TIPIN | Gene-based tests:X<sup>2</sup>=5.296, P-value = 0.108 in recessive model in SZ/SZA, X<sup>2</sup>=3.515, P-value = 0.237 in additive model in SZ/SZA, X<sup>2</sup>=3.622, P-value = 0.319 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA. | Negative |
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Last update: March 31, 2016