Study Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Mansour, H. A.,2009 PMID: 19839995
Citation	Mansour, H. A., M. E. Talkowski, et al. (2009). Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord 11(7): 701-710.
Disease Type	Bipolar I Disorder & Schizophrenia
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	523 patients with BPI, 527 with SZ ?SZA (314 SZ and 213 SZA) and 477 control individuals
SNP/Region/Marker Size	276 SNPs
Predominant Ethnicity	Caucasian
Population	American
Gender	male/female:225/298 in patients with BPI,340/187 in patients with SZ ?SZA;229/248 in control individuals
Age Group	mean age(year):43.11(SD=12.71) in patients with BPI, 37.31(SD=10.12) in patients with SZ ?SZA, 46.44(SD=16.72) in control individuals

Detail Info

Sample Diagnosis	DSM
Sample Status	Genomic DNA samples were obtained from BPI patients recruited through the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD).Unrelated patients with SZ or SZA (according to DSM-IV criteria) were recruited at Western Psychiatric Institute and Clinic,Pittsburgh, PA, USA, and surrounding regions(N = 527; n = 314 SZ and n = 213 SZA).Two sets of adult controls screened for absence of psychosis or BPI were included: a Pittsburgh-based sample(n = 168) and a national sample available from the NIMH-GRI(n = 309).
Technique	genotyping
Statistical Method	LD was analyzed using Hclust software to select tag SNPs. Gene-based tests were conducted initially to test for associations, followed by tests with individual SNPs. For gene-based analyses, we used the (T-max) test of association fitting additive,dominant, and recessive models for each gene.SNP-based association analyses for the diagnostic phenotype were conducted using the Cochran-Armitage trend test.
Result Summary	RESULTS: Using gene-based tests, suggestive associations were noted between EGR3 and BPI (p = 0.017), and between NPAS2 and SZ/SZA (p = 0.034). Three SNPs were associated with both sets of disorders (NPAS2: rs13025524 and rs11123857; RORB: rs10491929; p < 0.05). None of the associations remained significant following corrections for multiple comparisons. Approximately 15% of the analyzed SNPs overlapped with an independent study that conducted GWAS for BPI; suggestive overlap between the GWAS analyses and ours was noted at ARNTL. CONCLUSIONS: Several suggestive, novel associations were detected with circadian genes and BPI and SZ/SZA, but the present analyses do not support associations with common polymorphisms that confer risk with odds ratios greater than 1.5. Additional analyses using adequately powered samples are warranted to further evaluate these results.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 15)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs10217594	RORB	A/G	Single SNP-based analyses: Trends test P-value = 0.026 in BPI	Significant association was observed Significant association was observed	Positive
rs7126303	ARNTL RN7SKP151	A/G	Single SNP-based analyses: Trends test P-value = 0.04 in BPI	Significant association was observed Significant association was observed	Positive
rs6543004	NPAS2	A/T	Single SNP-based analyses: Trends test P-value = 0.139 in BPI	No significant association was observed No significant association was observed	Negative
rs2304672	PER2	C/G	Single SNP-based analyses: Trends test P-value = 0.342 in BPI	No significant association was observed No significant association was observed	Negative
rs1997644	CSNK1E	A/G	Single SNP-based analyses: Trends test P-value = 0.024 in BPI	Significant association was observed Significant association was observed	Positive
rs2640909	PER3		Single SNP-based analyses: Trends test P-value = 0.421 in BPI	No significant association was observed No significant association was observed	Negative
rs2304674	PER2	A/G	Single SNP-based analyses: Trends test P-value = 0.051 in BPI	No significant association was observed No significant association was observed	Negative
rs17025005	NPAS2	A/G	Single SNP-based analyses: Trends test P-value = 0.009 in BPI	Significant association was observed Significant association was observed	Positive
rs1554338	CRY2 MAPK8IP1	A/G	Single SNP-based analyses: Trends test P-value = 0.031 in BPI	Significant association was observed Significant association was observed	Positive
rs1996147	EGR3	A/G	Single SNP-based analyses: Trends test P-value = 0.006 in BPI	Significant association was observed Significant association was observed	Positive
rs17691363	RORB	A/G	Single SNP-based analyses: Trends test P-value = 0.035 in BPI	Significant association was observed Significant association was observed	Positive
rs10491929	RORB	A/G	Single SNP-based analyses: Trends test P-value = 0.023 in BPI	Significant association was observed Significant association was observed	Positive
rs10462021	PER3		Single SNP-based analyses: Trends test P-value = 0.334 in BPI	No significant association was observed No significant association was observed	Negative
rs13025524	NPAS2	A/G	Single SNP-based analyses: Trends test P-value = 0.016 in BPI	Significant association was observed Significant association was observed	Positive
rs11123857	NPAS2	A/G	Single SNP-based analyses: Trends test P-value = 0.036 in BPI	Significant association was observed Significant association was observed	Positive

Genes reported by this study for BD (count: 21)

Gene	Statistical Values/Author Comments	Result Category
NPAS2	Gene-based tests:X<sup>2</sup>=6.629, P-value = 0.326 in additive model, X<sup>2</sup>=5.686, P-value = 0.553 in dominant model, X<sup>2</sup>=5.077, P-value = 0.701 in recessive model in BPI. Significant association was observed using single SNP-based analyses while no association was observ...... Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More...	Positive
AANAT	Gene-based tests:X<sup>2</sup>=1.997, P-value = 0.482 in additive model, X<sup>2</sup>=1.811, P-value = 0.538 in dominant model, X<sup>2</sup>=1.818, P-value = 0.55 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
CLOCK	Gene-based tests:X<sup>2</sup>=5.096, P-value = 0.142 in dominant model, X<sup>2</sup>=3.578, P-value = 0.434 in recessive model, X<sup>2</sup>=2.556, P-value = 0.524 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
RORB	Gene-based tests:X<sup>2</sup>=7.436, P-value = 0.203 in recessive model, X<sup>2</sup>=5.403, P-value = 0.475 in dominant model, X<sup>2</sup>=4.907, P-value = 0.5 in additive model in BPI. Significant association was observed using single SNP-based analyses while no association was observ...... Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More...	Positive
PER3	Gene-based tests:X<sup>2</sup>=3.663, P-value = 0.487 in recessive model, X<sup>2</sup>=2.145, P-value = 0.784 in dominant model, X<sup>2</sup>=1.5, P-value = 0.847 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
NR1D1	Gene-based tests:X<sup>2</sup>=2.973, P-value = 0.385 in dominant model, X<sup>2</sup>=3.107, P-value = 0.409 in recessive model, X<sup>2</sup>=2.316, P-value = 0.456 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
ARNTL	Gene-based tests:X<sup>2</sup>=4.293, P-value = 0.422 in additive model, X<sup>2</sup>=4.05, P-value = 0.566 in dominant model, X<sup>2</sup>=2.854, P-value = 0.8 in recessive model in BPI. Association was observed using single SNP-based analyses while no association was observed using gen...... Association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More...	Positive
BHLHE41	Gene-based tests:X<sup>2</sup>=0.786, P-value = 0.708 in additive model, X<sup>2</sup>=0.86, P-value = 0.717 in dominant model, X<sup>2</sup>=0.471, P-value = 0.868 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
EGR3	Gene-based tests:X<sup>2</sup>=7.248, P-value = 0.014 in recessive model, X<sup>2</sup>=7.659, P-value = 0.02 in additive model, X<sup>2</sup>=2.613, P-value = 0.288 in dominant model in BPI. Significant association was observed using both single SNP-based analyses and gene-based tests in BP...... Significant association was observed using both single SNP-based analyses and gene-based tests in BPI. More...	Positive
PER2	Gene-based tests:X<sup>2</sup>=7.226, P-value = 0.062 in recessive model, X<sup>2</sup>=3.587, P-value = 0.336 in additive model, X<sup>2</sup>=1.828, P-value = 0.849 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
CRY2	Gene-based tests:X<sup>2</sup>=5.443, P-value = 0.119 in recessive model, X<sup>2</sup>=4.967, P-value = 0.133 in additive model, X<sup>2</sup>=1.486, P-value = 0.768 in dominant model in BPI. Significant association was observed using single SNP-based analyses while no association was observ...... Significant association was observed using single SNP-based analyses while no association was observed using gene-based tests in BPI. More...	Positive
PER1	Gene-based tests:X<sup>2</sup>=4.005, P-value = 0.111 in recessive model, X<sup>2</sup>=0.81, P-value = 0.544 in dominant model, X<sup>2</sup>=0.15, P-value = 0.893 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
ARNTL2	Gene-based tests:X<sup>2</sup>=4.067, P-value = 0.559 in recessive model, X<sup>2</sup>=4.068, P-value = 0.591 in dominant model, X<sup>2</sup>=3.171, P-value = 0.699 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
CSNK1E	Gene-based tests:X<sup>2</sup>=6.251, P-value = 0.098 in recessive model, X<sup>2</sup>=5.354, P-value = 0.14 in additive model, X<sup>2</sup>=3.728, P-value = 0.354 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
CNR1	Gene-based tests:X<sup>2</sup>=4.971, P-value = 0.304 in recessive model, X<sup>2</sup>=3.233, P-value = 0.623 in dominant model, X<sup>2</sup>=2.629, P-value = 0.643 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
DBP	Gene-based tests:X<sup>2</sup>=2.109, P-value = 0.273 in recessive model, X<sup>2</sup>=1.578, P-value = 0.377 in dominant model, X<sup>2</sup>=0.703, P-value = 0.632 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
CSNK1D	Gene-based tests:X<sup>2</sup>=3.077, P-value = 0.125 in recessive model, X<sup>2</sup>=0.286, P-value = 0.613 in additive model, X<sup>2</sup>=0.001, P-value = 1 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
TIMELESS	Gene-based tests:X<sup>2</sup>=3.072, P-value = 0.271 in recessive model, X<sup>2</sup>=0.332, P-value = 0.968 in additive model, X<sup>2</sup>=0.251, P-value = 0.993 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
CSNK2A1	Gene-based tests:X<sup>2</sup>=5.274, P-value = 0.136 in dominant model, X<sup>2</sup>=2.372, P-value = 0.551 in recessive model, X<sup>2</sup>=1.527, P-value = 0.687 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
NFIL3	Gene-based tests:X<sup>2</sup>=3.129, P-value = 0.448 in dominant model, X<sup>2</sup>=2.497, P-value = 0.575 in additive model, X<sup>2</sup>=2.136, P-value = 0.699 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative
TIPIN	Gene-based tests:X<sup>2</sup>=4.334, P-value = 0.184 in dominant model, X<sup>2</sup>=3.796, P-value = 0.209 in additive model, X<sup>2</sup>=1.885, P-value = 0.608 in recessive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based test...... No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs10217594	RORB	Single SNP-based analyses:Trends test P-value = 0.313 in SZ	No significant association was observed	Negative
SZ	rs10462021	PER3	Single SNP-based analyses:Trends test P-value = 0.036 in SZ	Significant association was observed	Positive
SZ	rs17025005	NPAS2	Single SNP-based analyses:Trends test P-value = 0.085 in SZ	No significant association was observed	Negative
SZ	rs17691363	RORB	Single SNP-based analyses:Trends test P-value = 0.983 in SZ	No significant association was observed	Negative
SZ	rs1996147	EGR3	Single SNP-based analyses:Trends test P-value = 0.193 in SZ	No significant association was observed	Negative
SZ	rs1997644	CSNK1E	Single SNP-based analyses:Trends test P-value = 0.363 in SZ	No significant association was observed	Negative
SZ	rs10491929	RORB	Single SNP-based analyses:Trends test P-value = 0.023 in SZ	Significant association was observed	Positive
SZ	rs11123857	NPAS2	Single SNP-based analyses:Trends test P-value = 0.038 in SZ	Significant association was observed	Positive
SZ	rs13025524	NPAS2	Single SNP-based analyses:Trends test P-value = 0.025 in SZ	Significant association was observed	Positive
SZ	rs1554338	CRY2 MAPK8IP1	Single SNP-based analyses:Trends test P-value = 0.411 in SZ	No significant association was observed	Negative
SZ	rs7126303	ARNTL RN7SKP151	Single SNP-based analyses:Trends test P-value = 0.738 in SZ	No significant association was observed	Negative
SZ	rs2304674	PER2	Single SNP-based analyses:Trends test P-value = 0.033 in SZ	Significant association was observed	Positive
SZ	rs2304672	PER2	Single SNP-based analyses:Trends test P-value = 0.048 in SZ	Significant association was observed	Positive
SZ	rs6543004	NPAS2	Single SNP-based analyses:Trends test P-value = 0.024 in SZ	Significant association was observed	Positive
SZ	rs2640909	PER3	Single SNP-based analyses:Trends test P-value = 0.031 in SZ	Significant association was observed	Positive

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	CSNK1E	Gene-based tests:X<sup>2</sup>=3.815, P-value = 0.347 in dominant model in SZ/SZA, X<sup>2</sup>=2.768, P-value = 0.564 in recessive model in SZ/SZA, X<sup>2</sup>=1.423, P-value = 0.814 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	PER2	Gene-based tests:X<sup>2</sup>=6.944, P-value = 0.068 in recessive model in SZ/SZA, X<sup>2</sup>=4.563, P-value = 0.209 in additive model in SZ/SZA, X<sup>2</sup>=1.671, P-value = 0.769 in dominant model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA.	Positive
SZ	CLOCK	Gene-based tests:X<sup>2</sup>=1.83, P-value = 0.708 in additive model in SZ/SZA, X<sup>2</sup>=2.214, P-value = 0.73 in dominant model in SZ/SZA, X<sup>2</sup>=1.351, P-value = 0.908 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	ARNTL2	Gene-based tests:X<sup>2</sup>=6.36, P-value = 0.196 in dominant model in SZ/SZA, X<sup>2</sup>=4.7, P-value = 0.434 in recessive model in SZ/SZA, X<sup>2</sup>=3.236, P-value = 0.678 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	CSNK1D	Gene-based tests:X<sup>2</sup>=2.253, P-value = 0.137 in additive model in SZ/SZA, X<sup>2</sup>=2.015, P-value = 0.173 in dominant model in SZ/SZA, X<sup>2</sup>=0.733, P-value = 0.425 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	DBP	Gene-based tests:X<sup>2</sup>=2.864, P-value = 0.173 in dominant model in SZ/SZA, X<sup>2</sup>=2.134, P-value = 0.251 in recessive model in SZ/SZA, X<sup>2</sup>=1.57, P-value = 0.371 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	CNR1	Gene-based tests:X<sup>2</sup>=3.898, P-value = 0.389 in additive model in SZ/SZA, X<sup>2</sup>=4.189, P-value = 0.404 in dominant model in SZ/SZA, X<sup>2</sup>=1.603, P-value = 0.957 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	PER1	Gene-based tests:X<sup>2</sup>=1.525, P-value = 0.481 in recessive model in SZ/SZA, X<sup>2</sup>=0.596, P-value = 0.64 in dominant model in SZ/SZA, X<sup>2</sup>=0.389, P-value = 0.725 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	BHLHE41	Gene-based tests:X<sup>2</sup>=0.6, P-value = 0.829 in recessive model in SZ/SZA, X<sup>2</sup>=0.282, P-value = 0.94 in dominant model in SZ/SZA, X<sup>2</sup>=0.1, P-value = 0.985 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	PER3	Gene-based tests:X<sup>2</sup>=4.723, P-value = 0.245 in additive model in SZ/SZA, X<sup>2</sup>=4.379, P-value = 0.319 in dominant model in SZ/SZA, X<sup>2</sup>=4.42, P-value = 0.349 in recessive model in SZ/SZA. Association was observed using single SNP-based analyses while no association was observed using gene-based tests in SZ/SZA.	Positive
SZ	NPAS2	Gene-based tests:X<sup>2</sup>=11.321, P-value = 0.034 in recessive model in SZ/SZA, X<sup>2</sup>=7.892, P-value = 0.205 in dominant model in SZ/SZA, X<sup>2</sup>=5.146, P-value = 0.558 in additive model in SZ/SZA. Nominally significant associations were also noted with the SZ /SZA sample at NPAS2 under a recessive model.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA.	Positive
SZ	ARNTL	Gene-based tests:X<sup>2</sup>=3.334, P-value = 0.621 in additive model in SZ/SZA, X<sup>2</sup>=2.424, P-value = 0.882 in recessive model in SZ/SZA, X<sup>2</sup>=2.346, P-value = 0.913 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	CSNK2A1	Gene-based tests:X<sup>2</sup>=3.126, P-value = 0.381 in recessive model in SZ/SZA, X<sup>2</sup>=2.752, P-value = 0.47 in dominant model in SZ/SZA, X<sup>2</sup>=1.354, P-value = 0.719 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	RORB	Gene-based tests:X<sup>2</sup>=9.945, P-value = 0.056 in dominant model in SZ/SZA, X<sup>2</sup>=5.51, P-value = 0.407 in additive model in SZ/SZA, X<sup>2</sup>=4.505, P-value = 0.699 in recessive model in SZ/SZA.Association was observed using both single SNP-based analyses and gene-based tests in SZ/SZA.	Positive
SZ	NR1D1	Gene-based tests:X<sup>2</sup>=4.633, P-value = 0.182 in recessive model in SZ/SZA, X<sup>2</sup>=2.144, P-value = 0.543 in dominant model in SZ/SZA, X<sup>2</sup>=0.572, P-value = 0.945 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	TIMELESS	Gene-based tests:X<sup>2</sup>=3.823, P-value = 0.21 in recessive model in SZ/SZA, X<sup>2</sup>=3.599, P-value = 0.22 in additive model in SZ/SZA, X<sup>2</sup>=3.378, P-value = 0.298 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	AANAT	Gene-based tests:X<sup>2</sup>=3.101, P-value = 0.268 in additive model in SZ/SZA, X<sup>2</sup>=2.817, P-value = 0.34 in dominant model in SZ/SZA, X<sup>2</sup>=2.747, P-value = 0.345 in recessive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	NFIL3	Gene-based tests:X<sup>2</sup>=4.24, P-value = 0.276 in dominant model in SZ/SZA, X<sup>2</sup>=3.605, P-value = 0.369 in recessive model in SZ/SZA, X<sup>2</sup>=3.128, P-value = 0.438 in additive model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	CRY2	Gene-based tests:X<sup>2</sup>=1.267, P-value = 0.767 in additive model in SZ/SZA, X<sup>2</sup>=1.576, P-value = 0.788 in recessive model in SZ/SZA, X<sup>2</sup>=0.701, P-value = 0.954 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	EGR3	Gene-based tests:X<sup>2</sup>=1.294, P-value = 0.469 in recessive model in SZ/SZA, X<sup>2</sup>=1.601, P-value = 0.495 in additive model in SZ/SZA, X<sup>2</sup>=0.774, P-value = 0.759 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative
SZ	TIPIN	Gene-based tests:X<sup>2</sup>=5.296, P-value = 0.108 in recessive model in SZ/SZA, X<sup>2</sup>=3.515, P-value = 0.237 in additive model in SZ/SZA, X<sup>2</sup>=3.622, P-value = 0.319 in dominant model in SZ/SZA.No association was observed using neither single SNP-based analyses nor gene-based tests in SZ/SZA.	Negative