Meta-analysis Report

Reference	Vassos, E.,2012 PMID: 22560537
Citation	Vassos, E., S. Steinberg, et al. (2012). "Replication Study and Meta-Analysis in European Samples Supports Association of the 3p21.1 Locus with Bipolar Disorder." Biol Psychiatry.
Disease Type	Bipolar Disorder & Schizophrenia
Study Type	Candidate-gene association study

Samples	2562 cases with BP and 25,439 control subjects collected from seven cohorts,8794 SZ cases and 25,457 control subjects
Statistic Method	Results from the different case-control groups were combined with the fixed effect (inverse variance) method. Evidence for heterogeneity between samples was assessed with Cochran’s Q and I2 statistics (25).
Basic Result	In our dataset, rs2251219 was associated with BP (odds ratio [OR] = .89, p = .003), and meta-analysis of previously published data with our nonoverlapping new data confirmed genome-wide significant association (OR = .875, p = 2.68 x 10(-9)). Genotypic data from the SGENE-plus consortium were used to examine the association of the same variant with schizophrenia in an overall sample of 8794 cases and 25,457 control subjects, but this was not statistically significant (OR = .97, p = .21). CONCLUSIONS: There is strong evidence of association of rs2251219 with BP. However, our data do not support association of this marker with schizophrenia. Because the region of association has high linkage disequilibrium, forming a large haplotype block across many genes, it is not clear which gene is causally implicated in the disorder.