BDgene

Study Report

Basic Info
Reference
Citation McAuley, E. Z., A. Scimone, et al. (2012). "Identification of Sialyltransferase 8B as a Generalized Susceptibility Gene for Psychotic and Mood Disorders on Chromosome 15q25-26." PLoS One 7(5): e38172.
Disease Type Bipolar Disorder & Schizophrenia
Study Design case-control
Study Type Candidate-gene association study
Sample Size 219 cases and 166 controls in bipolar disorder case control cohort, 310 cases and 128 controls in the Schizophrenia cohort
SNP/Region/Marker Size 349 SNPs
Predominant Ethnicity Caucasian
Population Australian and American
Gender 50% were female of Australian Bipolar disorder cohort, 85 men and 43 women cases in the Australian Schizophrenia cohort
Age Group adults : average age of cases=46.7 (SD=15.3), average age of controls=60.3 (SD=13.5) for bipolar disorder case control cohort

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 18)

Haplotypes reported by this study for BD (count: 4)

Genes reported by this study for BD (count: 5)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs11074070 ST8SIA2 ENO1P2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs1455773 ST8SIA2 C15orf32 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs13380006 ST8SIA2 C15orf32 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs12441404 ST8SIA2 C15orf32 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs11637898 ST8SIA2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs3784735 ST8SIA2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs2280468 ACAN P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs2168351 ST8SIA2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs2035645 ST8SIA2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs3858917 ST8SIA2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs4586379 ST8SIA2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs4777760 RGMA P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs4777974 ST8SIA2 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs6496898 SLCO3A1 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs7169541 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs7174649 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs7175812 SLCO3A1 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative
SZ rs871167 SLCO3A1 P-value > 0.075 Single SNP analysis did not yield significant evidence for association. Negative

Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645 C-C-C-C-G ST8SIA2 P-value = 0.408, X<sup>2</sup>=0.68, OR (95% CI)=0.938 (0.81-1.09) in NIMH SZ No significant association was reported in this study. Negative
SZ rs4586379 - rs8025225 - rs11074066 - rs11074067 - rs2035645 T-T-A-G-T ST8SIA2 P-value = 0.129, X<sup>2</sup>=2.30, OR (95% CI)=1.09 (0.97-1.23) in NIMH SZ This haplotype also showed the same direction of effect in the NIMH cases with schizophrenia compared to controls, although it did not reach statistical significance. Negative
SZ rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735 G-C-A-A-C-C ST8SIA2 P-value = 0.021, X<sup>2</sup>=5.30, OR (95% CI)=0.515 (0.29-0.92) in Aus SZ the protective haplotype was over-represented in controls on conditional haplotype analysis Positive
SZ rs4586379 - rs2035645 - rs4777974 - rs11637898 - rs11074070 - rs3784735 A-A-G-G-A-A ST8SIA2 P-value = 0.004, X<sup>2</sup>=8.41, OR (95% CI)=1.82 (1.2-2.74) in Aus SZ We found that the specific AAGGAA risk haplotype was significantly over-represented in schizophrenia cases compared to controls when a conditional analysis was performed. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ SLCO3A1 No significant association was reported in this study. Negative
SZ ST8SIA2 These findings suggest that variation the ST8SIA2 gene is associated with increased risk to mental illness, acting to restrict neuronal plasticity and disrupt early neuronal network formation, rendering the developing and adult brain more vulnerable to secondary genetic or environmental insults. Positive
SZ ACAN No significant association was reported in this study. Negative
SZ RGMA No significant association was reported in this study. Negative
SZ C15orf32 No significant association was reported in this study. Negative