BDgene

Study Report

Basic Info
Reference
Citation Chowdari, K. V., K. Mirnics, et al. (2002). "Association and linkage analyses of RGS4 polymorphisms in schizophrenia." Hum Mol Genet 11(12): 1373-1380.
Disease Type Bipolar Disorder & Schizophrenia
Study Design family-based
Study Type Candidate-gene association study
Sample Size Pittsburgh schizophrenia cases and parents:Caucasian inpatients and outpatients with schizophrenia (n=55) or schizoaffective disorder (n=38);Pittsburgh bipolar I disorder cases:n=101;National Institute of Mental Health Collaborative Genetics Initiative (NIMH CGI) sample:39 cases, their parents and 30 affected sib-pairs were obtained.They comprised 25 families.Indian schizophrenia cases and parents:A total of 269 case-parent trio and 72 affected sib-pair families were analyzed.
SNP/Region/Marker Size 13 SNPs
Predominant Ethnicity
Population American,Indian and NIMH collections

Detail Info

Genetic factors reported by this study for BD
Haplotypes reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
SZ (RGS4_SNP1) - (RGS4_SNP4) - (RGS4_SNP7) - (RGS4_SNP18) RGS4 Estimated haplotype frequencies among cases and unrelated controls:P>0.05 No significant association was observed in SZ. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ RGS4 No significant association of RGS4 gene was observed in SZ. Negative