Meta-analysis Report

Basic Info

Reference	Sun, Y., 2015 PMID: 25667193
Citation	Sun, Y., et al. (2015). "Association between variants of zinc finger genes and psychiatric disorders: systematic review and meta-analysis." Schizophr Res 162(1-3): 124-137.
Disease Type	Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Type	candidate-gene association study

Detail Info

Samples	24 studies (49 data) were chosen for the meta-analysis of ZNF804A SNPs (Table 1), and 9 studies (10 data) were chosen for the metaanalysis of ZKSCAN4 and ZDHHC8.
Statistic Method	We conducted meta-analytical calculations using Review Manager 5.0 if at least two papers focused on the same genetic association. Heterogeneity between individual studies was tested using the Cochran's (Q) Ï‡2 test. We conducted meta-analytical calculations using Review Manager 5.0 if at least two papers focused on the same genetic association. Heterogeneity between individual studies was tested using the Cochran's (Q) Ï‡2 test.
Basic Result	We verified that ZNF804A was significantly related to psychiatric diseases, and the association between ZNF804A rs1344706 and psychosis (schizophrenia and bipolar disorder) did not vary with disease or ethnicity. The main brain area regulated by ZNF804A rs1344706 was the dorsolateral prefrontal cortex. The effect of ZNF804A variants on cognition did not display consistency with different diseases or methodologies. These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 1)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs1344706	ZNF804A			P-value=0.2, I²=38%, chi-square=3.24, df=2; test for overall effect: P-value=0.003, Z=2.93	We also found a significant association betweenthe T-allele ...... We also found a significant association betweenthe T-allele of rs1344706 and bipolar disorder in the fixed-effect analysis. More...	Positive

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
ZNF804A	These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatr...... These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes. More...	Positive

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
SZ	rs1344706	ZNF804A	P-value<0.00001, I²=71%, chi-square=100.88 df=29, Heterrogeneity Tau²=0.01	In the subgroup analysis of diseases, we found a significant associationbetween the T-allele of rs1344706 and schizophrenia in the random effect meta-analysis	Positive

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	ZNF804A	These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes.	Positive