BDgene

Meta-analysis Report

Basic Info
Reference
Citation Sun, Y., et al. (2015). "Association between variants of zinc finger genes and psychiatric disorders: systematic review and meta-analysis." Schizophr Res 162(1-3): 124-137.
Disease Type Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Type candidate-gene association study

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
SZ rs1344706 ZNF804A P-value<0.00001, I2=71%, chi-square=100.88 df=29, Heterrogeneity Tau2=0.01 In the subgroup analysis of diseases, we found a significant associationbetween the T-allele of rs1344706 and schizophrenia in the random effect meta-analysis Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ ZNF804A These findings suggest that ZNF804A might play an important role in common pathogenesis of psychiatric diseases, and its variants are likely involved in regulating the expression of psychosis-related genes, especially the dopamine pathway genes. Further research should focus on the molecular mechanisms by which ZNF804A variants act in psychiatric diseases and related phenotypes. Positive