Study Report

Basic Info

Reference	Arinami, T.,1997 PMID: 9342205
Citation	Arinami, T., N. Yamada, et al. (1997). "Methylenetetrahydrofolate reductase variant and schizophrenia/depression." Am J Med Genet 74(5): 526-528.
Disease Type	Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	297 schizophrenics, 32 patients with major depression, 40 patients with bipolar disorder, and 419 controls
SNP/Region/Marker Size	1 variant
Predominant Ethnicity	Mongloid
Population	Japanese
Gender	schizophrenics (169 males and 128 females),patients with major depression (13 males and 19 females), patients with bipolar disorder (24 males and 16 females), and controls (281 males and 138 females)
Age Group	Adults : schizophrenics with a mean,SD age of 45.2,13.0 years, patients with major depression with a mean,SD age of 58.2,11.6 years,patients with bipolar disorder with a mean,SD age of 54.2,12.4 years, and controls with a mean,SD age of 48.5,8.7 years

Detail Info

Sample Diagnosis	DSM
Technique	Genotyping
Statistical Method	Chi-square tests
Result Summary	The genotype homozygous for the T677 allele was significantly frequently observed in schizophrenics with an odds ratio of 1.9 (P = 0.0006), and in patients with major depression with an odds ratio of 2.8 (P = 0.005). Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese.

Genetic factors reported by this study for BD

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
MTHFR C677T	MTHFR	point mutation	C677T		Chi-square tests:P > 0.05,OR(95%CI) = 1.0 (0.5â€“2.8)	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
MTHFR	No significant differences were found in bipolar groups for MTHFR gene. No significant differences were found in bipolar groups for MTHFR gene.	Negative

Genetic factors reported by this study for SZ and/or MDD

Other variants reported by this study for SZ/MDD

Disease	Variant Name	Related Gene	Type	Statistical Values	Description	Result Category
SZ	MTHFR C677T	MTHFR	point mutation	Chi-square tests:P < 0.006,OR(95%CI) = 1.9 (1.3â€“2.9)	Significant differences were found in SZ groups.	Positive
MDD	MTHFR C677T	MTHFR	point mutation	Chi-square tests:P < 0.006,OR(95%CI) = 2.8 (1.3â€“6.4)	There was a significant difference between patients with unipolar disorder and controls.	Positive

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	MTHFR	The genotype homozygous for the T677 allele was significantly frequently observed in schizophrenics with an odds ratio of 1.9 (P = 0.0006), and in patients with major depression with an odds ratio of 2.8 (P = 0.005). Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese.	Positive
MDD	MTHFR	The genotype homozygous for the T677 allele was significantly frequently observed in schizophrenics with an odds ratio of 1.9 (P = 0.0006), and in patients with major depression with an odds ratio of 2.8 (P = 0.005). Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese.	Positive