GO Report

Basic Info

ID	GO:0007268
Name	synaptic transmission
Type	biological process
No. of Genes in BDgene	116
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
GO: 0007268: synaptic transmission	PBA paper	Askland, K.,2009	NIMH	Fisher's exact test	Results given for gene sets with P < 0.01 from the NIMH PBA-BP data

GO related genes in BDgene (count: 116)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)	Evidence[PMID]
CACNB2	calcium channel, voltage-dependent, beta 2 subunit	10p12	3(2/1/0)	IBA
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1p36.1	1(0/1/0)	TAS
VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)	17p13.1	1(1/0/0)	TAS
SSTR1	somatostatin receptor 1	14q13	1(1/0/0)	IBA
SST	somatostatin	3q28	1(0/1/0)	TAS[9437026]
DRD4	dopamine receptor D4	11p15.5	13(1/12/0)	IBA
HTR3B	5-hydroxytryptamine (serotonin) receptor 3B, ionotropic	11q23.1	2(1/1/0)	TAS[9950429]
GRIA1	glutamate receptor, ionotropic, AMPA 1	5q33	2(2/0/0)	TAS
NRXN1	neurexin 1	2p16.3	1(1/0/0)	ISS
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	2(0/2/0)	TAS
KCNN3	potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3	1q21.3	7(1/6/0)	TAS
CHAT	choline O-acetyltransferase	10q11.2	1(0/1/0)	TAS
GRM3	glutamate receptor, metabotropic 3	7q21.1-q21.2	7(3/4/0)	TAS[8840013]
KCNQ2	potassium channel, voltage gated KQT-like subfamily Q, member 2	20q13.33	1(1/0/0)	TAS
DLG3	discs, large homolog 3 (Drosophila)	Xq13.1	1(0/1/0)	IBA; TAS
DRD5	dopamine receptor D5	4p16.1	2(0/2/0)	NAS[7727453]
GABRB2	gamma-aminobutyric acid (GABA) A receptor, beta 2	5q34	1(1/0/0)	TAS
GRIP1	glutamate receptor interacting protein 1	12q13.13	1(1/0/0)	TAS
HTR7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	10q21-q24	2(0/2/0)	IEA
CHRNB2	cholinergic receptor, nicotinic, beta 2 (neuronal)	1q21.3	1(1/0/0)	TAS
SLC18A2	solute carrier family 18 (vesicular monoamine transporter), member 2	10q25	1(1/0/0)	TAS[15217342]
GRIA3	glutamate receptor, ionotropic, AMPA 3	Xq25	1(0/1/0)	TAS
CACNG2	calcium channel, voltage-dependent, gamma subunit 2	22q13.1	3(3/0/0)	TAS
MAOA	monoamine oxidase A	Xp11.4-p11.3	21(10/11/0)	TAS
PICK1	protein interacting with PRKCA 1	22q13.1	1(0/1/0)	TAS
CHRNA3	cholinergic receptor, nicotinic, alpha 3 (neuronal)	15q24	3(1/2/0)	TAS
GABRA1	gamma-aminobutyric acid (GABA) A receptor, alpha 1	5q34	2(1/1/0)	TAS
GAD1	glutamate decarboxylase 1 (brain, 67kDa)	2q31	2(1/1/0)	TAS
RASGRF2	Ras protein-specific guanine nucleotide-releasing factor 2	5q13	1(0/0/1)	TAS
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	3p21.31	1(0/1/0)	TAS
GRM7	glutamate receptor, metabotropic 7	3p26-p25	3(2/1/0)	IDA[9473604]
CHRNA9	cholinergic receptor, nicotinic, alpha 9 (neuronal)	4p14	2(0/2/0)	TAS
GABRA6	gamma-aminobutyric acid (GABA) A receptor, alpha 6	5q34	1(0/1/0)	TAS
GRIK4	glutamate receptor, ionotropic, kainate 4	11q23.3	2(1/1/0)	TAS
GABRR1	gamma-aminobutyric acid (GABA) A receptor, rho 1	6q15	1(1/0/0)	TAS
CARTPT	CART prepropeptide	5q13.2	1(0/1/0)	IEA
ADCY9	adenylate cyclase 9	16p13.3	2(1/1/0)	TAS
GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	12p13	2(1/1/0)	TAS
GRM2	glutamate receptor, metabotropic 2	3p21.2	1(0/1/0)	TAS[7620613]
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	1q25.3	1(1/0/0)	IBA; TAS
CACNB3	calcium channel, voltage-dependent, beta 3 subunit	12q13	1(0/0/1)	IBA; TAS
KCNMB2	potassium channel subfamily M regulatory beta subunit 2	3q26.32	1(1/0/0)	IBA; TAS
GABRA4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	4p12	2(2/0/0)	TAS
GRIK3	glutamate receptor, ionotropic, kainate 3	1p34.3	1(1/0/0)	TAS
NPFFR2	neuropeptide FF receptor 2	4q21	1(0/1/0)	IBA
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	12p13.3	20(17/3/0)	IEA
GABRB1	gamma-aminobutyric acid (GABA) A receptor, beta 1	4p12	3(2/0/1)	TAS
CHRNB4	cholinergic receptor, nicotinic, beta 4 (neuronal)	15q24	2(1/1/0)	TAS
CREB1	cAMP responsive element binding protein 1	2q34	2(1/1/0)	TAS
SYN2	synapsin II	3p25.2	1(0/1/0)	TAS[8964517]
GRM4	glutamate receptor, metabotropic 4	6p21.3	2(2/0/0)	IEA
NEFL	neurofilament, light polypeptide	8p21.2	1(0/1/0)	TAS
GABRA3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	Xq28	3(1/2/0)	TAS
MBP	myelin basic protein	18q23	1(1/0/0)	TAS[2434243]
SLC1A1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	9p24	1(1/0/0)	TAS[7521911]
CHRNA2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	8p21	3(0/3/0)	TAS
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11p13-p12	1(1/0/0)	TAS[7521911]
CHRNA5	cholinergic receptor, nicotinic, alpha 5 (neuronal)	15q24	3(2/1/0)	TAS[9009220]
PNOC	prepronociceptin	8p21	1(0/1/0)	IEA
SYPL1	synaptophysin-like 1	7q22.2	1(1/0/0)	TAS[8034131]
FGF12	fibroblast growth factor 12	3q28	1(0/1/0)	IEA
HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	1p36-p35	3(1/2/0)	TAS[8522988]
NPTX1	neuronal pentraxin I	17q25.3	2(1/1/0)	TAS[8884281]
NCALD	neurocalcin delta	8q22.3	1(0/1/0)	TAS
NRXN3	neurexin 3	14q31	2(2/0/0)	IEA
PPFIA1	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	11q13.3	1(1/0/0)	TAS
ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	12q24.12	3(3/0/0)	TAS
HTR1F	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	3p12	1(1/0/0)	TAS[8380639]
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	9q22.1-q22.3	2(0/2/0)	TAS
TSPO	translocator protein (18kDa)	22q13.3	3(1/2/0)	IEA
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	9q34	1(1/0/0)	IBA; TAS
PMCH	pro-melanin-concentrating hormone	12q23.2	1(1/0/0)	IEA
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	16p13.2	1(1/0/0)	TAS
KCNH7	potassium channel, voltage gated eag related subfamily H, member 7	2q24.3	3(2/0/1)	TAS
ADCY8	adenylate cyclase 8 (brain)	8q24	4(2/1/1)	TAS
GRIK2	glutamate receptor, ionotropic, kainate 2	6q16.3	3(1/1/1)	TAS
COMT	catechol-O-methyltransferase	22q11.21	28(14/14/0)	TAS
GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	15q12	3(1/2/0)	TAS
GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	15q12	1(0/1/0)	TAS
SLC6A3	solute carrier family 6 (neurotransmitter transporter), member 3	5p15.3	11(5/6/0)	TAS
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	12p13.1	8(4/4/0)	TAS
CHRNA1	cholinergic receptor, nicotinic, alpha 1 (muscle)	2q31.1	2(0/1/1)	TAS
GABRR3	gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene)	3q11.2	1(1/0/0)	NAS[10542332]; TAS
ADCY2	adenylate cyclase 2 (brain)	5p15.3	2(1/1/0)	TAS
SSTR5	somatostatin receptor 5	16p13.3	2(1/1/0)	IBA
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	9q34.3	3(2/1/0)	TAS
HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	1p36.3-p34.3	1(0/1/0)	IEA
CHRNB3	cholinergic receptor, nicotinic, beta 3 (neuronal)	8p11.21	3(1/2/0)	TAS
DLG2	discs, large homolog 2 (Drosophila)	11q21	3(1/1/1)	IBA
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Xq23	7(4/3/0)	TAS[9241279]
SLC6A2	solute carrier family 6 (neurotransmitter transporter), member 2	16q12.2	2(0/2/0)	TAS[2008212]
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	19q13.33	1(1/0/0)	TAS
HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11q23.1-q23.2	2(1/1/0)	TAS[7565620]
SLC6A5	solute carrier family 6 (neurotransmitter transporter), member 5	11p15.1	1(0/1/0)	TAS[9845349]
KCNK10	potassium channel, two pore domain subfamily K, member 10	14q31	1(1/0/0)	TAS
HCRTR1	hypocretin (orexin) receptor 1	1p33	1(1/0/0)	TAS[9491897]
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	10p13-p11.2	1(0/1/0)	TAS
HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	5q31-q33	2(1/1/0)	IEA
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	9q34	3(1/2/0)	TAS[2880016]
GRIK5	glutamate receptor, ionotropic, kainate 5	19q13.2	2(1/0/1)	TAS
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	5q32	2(1/1/0)	TAS
DRD3	dopamine receptor D3	3q13.3	19(4/15/0)	IBA
CRH	corticotropin releasing hormone	8q13	2(1/1/0)	TAS[7477348]
DLG1	discs, large homolog 1 (Drosophila)	3q29	2(1/1/0)	IBA; TAS
CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	15q13.3	4(2/2/0)	TAS
SNCG	synuclein, gamma (breast cancer-specific protein 1)	10q23.2-q23.3	1(0/1/0)	IEA
KCNQ3	potassium channel, voltage gated KQT-like subfamily Q, member 3	8q24	4(3/0/1)	TAS
NRXN2	neurexin 2	11q13	1(1/0/0)	IEA; ISS
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	6q14-q15	1(0/1/0)	IEA
HCRTR2	hypocretin (orexin) receptor 2	6p12.1	1(1/0/0)	TAS[9491897]
CHRNA4	cholinergic receptor, nicotinic, alpha 4 (neuronal)	20q13.33	1(1/0/0)	NAS[7550350]; TAS
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	2(2/0/0)	NAS[8760387]; TAS
KCND2	potassium channel, voltage gated Shal related subfamily D, member 2	7q31	1(1/0/0)	TAS[11102480]
CHRNA6	cholinergic receptor, nicotinic, alpha 6 (neuronal)	8p22	1(0/1/0)	TAS
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	13q14-q21	22(7/15/0)	TAS[9109547]
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	15q12	6(6/0/0)	TAS