Study Report

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Basic Info

Reference	Fallin, M. D.,2005 PMID: 16380905
Citation	Fallin, M. D., V. K. Lasseter, et al. (2005). Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. Am J Hum Genet 77(6): 918-936.
Disease Type	Bipolar I Disorder & Schizophrenia
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	BPI:337 trios from 323 families, SZ/SZA:274 trios from 263 families
SNP/Region/Marker Size	440 SNPs
Predominant Ethnicity	Caucasian
Population	Ashkenazi Jewish
Gender	50.6% female in BPI-affected subjects and 25.8% female in SZ/SZA
Age Group	Adults : Mean age onset(SD)(year): 21.5(7.3) in BPI-affected subjects and 19.5(4.5) in SZ/SZA

Detail Info

Sample Diagnosis	DSM
Sample Status	Over a 6-year period, we recruited individuals of AJ descent with BPI and SZ/SZA through advertisements in newspapers and Jewish newsletters, talks to community organizations, letters to leaders of the Jewish community, letters and talks to service providers, and a study Web site hosted by the Johns Hopkins Epidemiology-Genetics Program in Psychiatry. Case-parent trios were eligible for inclusion in these analyses if the proband met criteria for either a BPI diagnosis or an SZ or SZA diagnosis, according to the DSM-IV (American Psychiatric Association 1994), if both parents were available for DNA collection, and if four grandparents were known to be of AJ descent. Included in our trio data are 14 of the 29 multiplex families with SZ/SZA and 8 of the 22 multiplex families with BPI that had been included in previous autosomal linkage scans for these disorders (Fallin et al. 2003, 2004). Five multiplex families contributed two trios each to the BPI analysis, and eight multiplex families contributed two trios each to the SZ/SZA analysis; no family contributed more than two trios to either the BPI analyses or the SZ/SZA analyses. Also, 14 families were 'mixed', that is, they contained both BPI and SZ/SZA-affected subjects, but only the appropriate subject (proband with BPI for BPI analyses and proband with SZ/SZA for the SZ/SZA analyses) and his/her parents were included in either the SZ/SZA or BPI analyses. Of the BPI-affected cases, 66.7% had psychosis.Of the SZ/SZA trios, 57 (21%) had probands with SZA, with an average age at onset of 19.3(SD=5.4) years, and 33.3% were female.
Technique	genotyping
Statistical Method	Both single-SNP and haplotypebased transmission/disequilibrium test (TDT) analyses were performed.
Result Summary	Using single-SNP and haplotype-based transmission/disequilibrium tests, we ranked genes on the basis of strength of association (P<.01). Six genes (DAO, GRM3, GRM4, GRIN2B, IL2RB, and TUBA8) met this criterion for bipolar I disorder; only DAO has been previously associated with bipolar disorder. Six genes (RGS4, SCA1, GRM4, DPYSL2, NOS1, and GRID1) met this criterion for schizophrenia or schizoaffective disorder; five replicate previous associations, and one, GRID1, shows a novel association with schizophrenia. In addition, six genes (DPYSL2, DTNBP1, G30/G72, GRID1, GRM4, and NOS1) showed overlapping suggestive evidence of association in both disorders. These results may help to prioritize candidate genes for future study from among the many suspected/proposed for schizophrenia and bipolar disorders. They provide further support for shared genetic susceptibility between these two disorders that involve glutamate-signaling pathways.

Genetic factors reported by this study for BD

Genes reported by this study for BD (count: 64)

Gene	Statistical Values/Author Comments	Result Category
GRIN2B	31 SNP typed, Median D'=0.22, Median r<sup>2</sup> =0.02, 10 LD blocks, 0.51 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP and all SNP or haplotype P-value > 0.05 in SZ/SZA.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Positive
DGCR6	1 SNP typed, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DGCR6L	1 SNP typed, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DGCR14	5 SNP typed, Median D'=0.94, Median r<sup>2</sup> =0.17, 2 LD blocks, 0.65 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
TPP2	6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.25, 1 LD blocks, 0.73 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
GRID1	29 SNP typed, Median D'=0.21, Median r<sup>2</sup> =0.01, 13 LD blocks, 0.31 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and P-value > 0.01 and <0.05 in BP and SZ/SZA.. This gene is highly suggestive to SZ and suggestive to BP. This gene is highly suggestive to SZ and suggestive to BP.	Trend
RTN4R	4 SNP typed, Median D'=0.69, Median r<sup>2</sup> =0.42, 2 LD blocks, 0.07 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
GRM3	10 SNP typed, Median D'=0.77, Median r<sup>2</sup> =0.15, 3 LD blocks, 0.78 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Positive
IL2RB	7 SNP typed, Median D'=0.26, Median r<sup>2</sup> =0.01, 4 LD blocks, 0.09 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP and all SNP or haplotype P-value > 0.05 in SZ/SZA.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Positive
CHRNB3	4 SNP typed, Median D'=1, Median r<sup>2</sup> =0.23, 1 LD blocks, 0.88 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
ADRA1A	8 SNP typed, Median D'=0.32, Median r<sup>2</sup> =0.02, 4 LD blocks, 0.33 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
INA	3 SNP typed, Median D'=0.97, Median r<sup>2</sup> =0.88, 1 LD blocks, 0.81 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
MLC1	7 SNP typed, Median D'=0.94, Median r<sup>2</sup> =0.09, 2 LD blocks, 0.93 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
SNCG	5 SNP typed, Median D'=0.11, Median r<sup>2</sup> =0.01, 4 LD blocks, 0.01 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
TSPO	6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.26, 1 LD blocks, 0.99 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
DRD4	1 SNP typed, Median D'=â€¦, Median r<sup>2</sup> =â€¦, â€¦ LD blocks, â€¦ block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
MED15	6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.2, 1 LD blocks, 0.68 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
PI4KA	6 SNP typed, Median D'=1, Median r<sup>2</sup> =0.67, 1 LD blocks, 0.67 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
GFRA1	12 SNP typed, Median D'=0.24, Median r<sup>2</sup> =0.02, 5 LD blocks, 0.44 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
HTR7	8 SNP typed, Median D'=1, Median r<sup>2</sup> =0.04, 2 LD blocks, 0.84 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
TUBA8	2 SNP typed, Median D'=0.53, Median r<sup>2</sup> =0.03, 2 LD blocks, NA block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP and all SNP or haplotype P-value > 0.05 in SZ/SZA.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Positive
SLC15A1	7 SNP typed, Median D'=0.72, Median r<sup>2</sup> =0.03, 3 LD blocks, 0.28 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
IL17RA	2 SNP typed, Median D'=1, Median r<sup>2</sup> =0.56, 1 LD blocks, 0.07 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
SYNGAP1	1 SNP typed, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
GNRH1	3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.17, 1 LD blocks, 0.34 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DISC1	19 SNP typed, Median D'=0.16, Median r<sup>2</sup> =0, 10 LD blocks, 0.46 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DGCR8	3 SNP typed, Median D'=0.94, Median r<sup>2</sup> =0.12, 1 LD blocks, 0.89 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in BP.. This gene is suggestive to BP , not suggestive to SZ/SZA. This gene is suggestive to BP , not suggestive to SZ/SZA.	Trend
CABIN1	7 SNP typed, Median D'=0.99, Median r<sup>2</sup> =0.46, 1 LD blocks, 0.75 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in BP.. This gene is suggestive to BP , not suggestive to SZ/SZA. This gene is suggestive to BP , not suggestive to SZ/SZA.	Trend
COMT	7 SNP typed, Median D'=0.87, Median r<sup>2</sup> =0.36, 3 LD blocks, 0.73 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DTNBP1	16 SNP typed, Median D'=1, Median r<sup>2</sup> =0.05, 4 LD blocks, 0.59 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and BP.. This gene is suggestive to BP and SZ/SZA. This gene is suggestive to BP and SZ/SZA.	Trend
PICK1	5 SNP typed, Median D'=1, Median r<sup>2</sup> =0.28, 1 LD blocks, 0.84 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
ZNF74	3 SNP typed, Median D'=0.96, Median r<sup>2</sup> =0.46, 1 LD blocks, 0.51 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
TFAP2B	4 SNP typed, Median D'=1, Median r<sup>2</sup> =0.12, 1 LD blocks, 0.77 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DRD2	5 SNP typed, Median D'=0.95, Median r<sup>2</sup> =0.21, 1 LD blocks, 0.48 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
PNOC	7 SNP typed, Median D'=1, Median r<sup>2</sup> =0.09, 1 LD blocks, 0.67 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
ZIC2	3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.18, 1 LD blocks, 0.64 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
PPP3CB	3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.77, 1 LD blocks, 0.64 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
PPP3CC	9 SNP typed, Median D'=0.97, Median r<sup>2</sup> =0.88, 2 LD blocks, 0.86 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DRD1	2 SNP typed, Median D'=1, Median r<sup>2</sup> =0.99, 1 LD blocks, 0.36 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
NRG3	18 SNP typed, Median D'=0.14, Median r<sup>2</sup> =0.01, 10 LD blocks, 0.12 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
NOS1	9 SNP typed, Median D'=0.49, Median r<sup>2</sup> =0.07, 4 LD blocks, 0.2 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and SNP or haplotype P-value > 0.01 and <0.05 in BP.. This gene is highly suggestive to SZ/SZA and suggestive to BP. This gene is highly suggestive to SZ/SZA and suggestive to BP.	Trend
DPYSL2	8 SNP typed, Median D'=0.65, Median r<sup>2</sup> =0.08, 4 LD blocks, 0.57 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and P-value > 0.01 and <0.05 in BP.. This gene is highly suggestive to SZ/SZA and suggestive to BP. This gene is highly suggestive to SZ/SZA and suggestive to BP.	Trend
NRG1	12 SNP typed, Median D'=0.26, Median r<sup>2</sup> =0.01, 6 LD blocks, 0.04 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
NEFM	1 SNP typed, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
HTR2A	9 SNP typed, Median D'=0.29, Median r<sup>2</sup> =0.01, 4 LD blocks, 0.61 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
PRODH	6 SNP typed, Median D'=0.66, Median r<sup>2</sup> =0.03, 4 LD blocks, 0.07 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
KIF13A	13 SNP typed, Median D'=0.97, Median r<sup>2</sup> =0.34, 2 LD blocks, 0.72 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in BP.. This gene is suggestive to BP , not suggestive to SZ/SZA. This gene is suggestive to BP , not suggestive to SZ/SZA.	Trend
NEFL	3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.1, 1 LD blocks, 7.17 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
SNAP29	4 SNP typed, Median D'=1, Median r<sup>2</sup> =0.98, 1 LD blocks, 0.98 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DAO	5 SNP typed, Median D'=0.89, Median r<sup>2</sup> =0.26, 2 LD blocks, 0.27 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in BP and all SNP or haplotype P-value > 0.05 in SZ/SZA.. This gene is highly suggestive to BP , not suggestive to SZ/SZA. This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Positive
GRM4	6 SNP typed, Median D'=0.61, Median r<sup>2</sup> =0.08, 3 LD blocks, 0.24 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and in BP.. This gene is highly suggestive to BP and SZ/SZA. This gene is highly suggestive to BP and SZ/SZA.	Positive
UBE2L3	2 SNP typed, Median D'=1, Median r<sup>2</sup> =1, 1 LD blocks, 0.3 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
DAOA	14 SNP typed, Median D'=0.96, Median r<sup>2</sup> =0.15, 2 LD blocks, 1.33 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to BP and SZ/SZA. This gene is suggestive to BP and SZ/SZA.	Trend
ATXN1	23 SNP typed, Median D'=0.12, Median r<sup>2</sup> =0, 14 LD blocks, 0.25 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is highly suggestive to SZ/SZA , not suggestive to BP. This gene is highly suggestive to SZ/SZA , not suggestive to BP.	Negative
GSC2	1 SNP typed, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
UFD1L	5 SNP typed, Median D'=1, Median r<sup>2</sup> =0.12, 1 LD blocks, 0.73 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
LGI1	5 SNP typed, Median D'=0.34, Median r<sup>2</sup> =0.04, 4 LD blocks, 0.02 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in SZ/SZA and all SNP or haplotype P-value > 0.05 in BP.. This gene is suggestive to SZ/SZA , not suggestive to BP. This gene is suggestive to SZ/SZA , not suggestive to BP.	Negative
DRD3	5 SNP typed, Median D'=0.88, Median r<sup>2</sup> =0.3, 1 LD blocks, 0.55 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
YWHAH	8 SNP typed, Median D'=1, Median r<sup>2</sup> =0.35, 2 LD blocks, 1.23 block coverage, there exists SNP or haplotype nominal P-value > 0.01 and <0.05 in BP.. This gene is suggestive to BP , not suggestive to SZ/SZA. This gene is suggestive to BP , not suggestive to SZ/SZA.	Trend
NAT1	2 SNP typed, Median D'=0.04, Median r<sup>2</sup> =0, 2 LD blocks, NA block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
CHRNA2	4 SNP typed, Median D'=0.94, Median r<sup>2</sup> =0.1, 3 LD blocks, 0.01 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
FKBP5	5 SNP typed, Median D'=1, Median r<sup>2</sup> =0.58, 1 LD blocks, 0.34 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA... This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
MYOZ1	1 SNP typed, Median D'=â€¦, Median r<sup>2</sup> =â€¦, â€¦ LD blocks, â€¦ block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative
RGS4	3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.36, 1 LD blocks, 0.95 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is not suggestive to BP. This gene is not suggestive to BP.	Negative

Genetic factors reported by this study for SZ and/or MDD

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
SZ	DGCR6L	This gene is not suggestive to SZ/SZA.	Negative
SZ	CABIN1	This gene is suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	DAOA	This gene is suggestive to BP and SZ/SZA.	Trend
SZ	GRM3	This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	DTNBP1	This gene is suggestive to BP and SZ/SZA.	Trend
SZ	TUBA8	This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	UFD1L	This gene is not suggestive to SZ/SZA.	Negative
SZ	DRD3	This gene is not suggestive to SZ/SZA.	Negative
SZ	UBE2L3	This gene is not suggestive to SZ/SZA.	Negative
SZ	ZIC2	This gene is not suggestive to SZ/SZA.	Negative
SZ	KIF13A	This gene is suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	GRID1	This gene is highly suggestive to SZ and suggestive to BP.	Positive
SZ	LGI1	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	ATXN1	This gene is highly suggestive to SZ/SZA , not suggestive to BP.	Positive
SZ	YWHAH	This gene is suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	PICK1	This gene is not suggestive to SZ/SZA.	Negative
SZ	NAT1	This gene is not suggestive to SZ/SZA.	Negative
SZ	RGS4	This gene is highly suggestive to SZ.	Positive
SZ	MED15	This gene is not suggestive to SZ/SZA.	Negative
SZ	DRD4	This gene is not suggestive to SZ/SZA.	Negative
SZ	DGCR8	This gene is suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	NEFM	This gene is not suggestive to SZ/SZA.	Negative
SZ	SNAP29	This gene is not suggestive to SZ/SZA.	Negative
SZ	NEFL	This gene is not suggestive to SZ/SZA.	Negative
SZ	CHRNA2	This gene is not suggestive to SZ/SZA.	Negative
SZ	DRD2	This gene is not suggestive to SZ/SZA.	Negative
SZ	DRD1	This gene is not suggestive to SZ/SZA.	Negative
SZ	HTR2A	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	NRG3	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	PRODH	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	ZNF74	This gene is not suggestive to SZ/SZA.	Negative
SZ	PPP3CB	This gene is not suggestive to SZ/SZA.	Negative
SZ	COMT	This gene is not suggestive to SZ/SZA.	Negative
SZ	RTN4R	This gene is not suggestive to SZ/SZA.	Negative
SZ	PPP3CC	This gene is not suggestive to SZ/SZA.	Negative
SZ	TSPO	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	DAO	This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	TPP2	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	NOS1	This gene is highly suggestive to SZ/SZA and suggestive to BP.	Positive
SZ	GSC2	This gene is not suggestive to SZ/SZA.	Negative
SZ	HTR7	This gene is not suggestive to SZ/SZA.	Negative
SZ	SLC15A1	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	DISC1	This gene is not suggestive to SZ/SZA.	Negative
SZ	MYOZ1	This gene is not suggestive to SZ/SZA.	Negative
SZ	GNRH1	This gene is not suggestive to SZ/SZA.	Negative
SZ	GRIN2B	This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	INA	This gene is not suggestive to SZ/SZA.	Negative
SZ	MLC1	This gene is not suggestive to SZ/SZA.	Negative
SZ	NRG1	This gene is not suggestive to SZ/SZA.	Negative
SZ	PNOC	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	DGCR6	This gene is not suggestive to SZ/SZA.	Negative
SZ	DGCR14	This gene is not suggestive to SZ/SZA.	Negative
SZ	CHRNB3	This gene is not suggestive to SZ/SZA.	Negative
SZ	TFAP2B	This gene is not suggestive to SZ/SZA.	Negative
SZ	IL2RB	This gene is highly suggestive to BP , not suggestive to SZ/SZA.	Negative
SZ	IL17RA	This gene is not suggestive to SZ/SZA.	Negative
SZ	DPYSL2	This gene is highly suggestive to SZ/SZA and suggestive to BP.	Positive
SZ	GFRA1	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	FKBP5	This gene is not suggestive to SZ/SZA.	Negative
SZ	GRM4	This gene is highly suggestive to BP and SZ/SZA.	Positive
SZ	SNCG	This gene is not suggestive to SZ/SZA.	Negative
SZ	ADRA1A	This gene is suggestive to SZ/SZA , not suggestive to BP.	Trend
SZ	PI4KA	This gene is not suggestive to SZ/SZA.	Negative
SZ	SYNGAP1	This gene is not suggestive to SZ/SZA.	Negative