BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

BD & MDD shared genes

Search by:Disease = BD-MDD, Source = cross-disorder study, No. of Positive Studies for BD >= 1, No. of Positive Studies for MDD >= 1

Total unique gene count: 54

Note: For BD-MDD shared genes, genes from cross-disorder studies about BD-MDD or BD-SZ-MDD were considered from cross-disorder studies, genes from intersection analysis of BDgene and MK4MDD were considered from candidate gene intersection analysis. Some repeated genes may be both included in cross-disorder studies and the result of candidate gene intersection analysis.

From cross-disorder studies (count: 54)

Gene Symbol

No. of Studies (Positive/Negative/Trend) for BD

No. of Studies for MDD

Overlap with MDD

Reference	Source	Description (MK4MDD Link)	Category

SLC6A4

44(18/26/0)

9322234	Cross-disorder study	Our finding that the deleted allele of 5-HTTLPR is significa..... More Our finding that the deleted allele of 5-HTTLPR is significantly less common in lithium-treated unipolar probands than in controls may reflect a genuine drug response effect of this polymorphism or may simply reflect sampling variance. Less	Positive
9149321	Cross-disorder study	There was a significant difference between patients with uni..... More There was a significant difference between patients with unipolar disorder and controls in the proportion of individuals carrying the STin2.9 allele.The findings support the hypothesis that allelic variation in the serotonin transporter gene may contribute to susceptibility for both major depression and bipolar disorder. Less	Positive

9399688	Cross-disorder study	No significant association with unipolar depression was dete..... More No significant association with unipolar depression was detected using either genetic marker. Less	Negative
9514589	Cross-disorder study	These results suggest that the promoter allele 2 of 5-HTT, w..... More These results suggest that the promoter allele 2 of 5-HTT, which has previously been shown to result in lower levels of serotonin transporter transcription, may be associated with affective disorder risk. Less	Positive
21438144	Cross-disorder study	Significant associations of this gene were found in MDD pati..... More Significant associations of this gene were found in MDD patients. Less	Positive
11803453	Cross-disorder study	No significant association of 5HTTLPR was observed in MDD.	Negative
11240581	Cross-disorder study	No association related to the polymorphism was found in the ..... More No association related to the polymorphism was found in the promoter region of the serotonin transporter gene. Less	Negative
10780268	Cross-disorder study	Thus, we conclude that the SERT VNTR polymorphism may be a r..... More Thus, we conclude that the SERT VNTR polymorphism may be a risk factor for both schizophrenia and unipolar depression, but not for bipolar disorder, in the Han Chinese. Less	Positive
9514579	Cross-disorder study	our data suggest that the 5-HTT gene is not commonly involve..... More our data suggest that the 5-HTT gene is not commonly involved in the susceptibility to mood disorders. Less	Negative
10889543	Cross-disorder study	Our data suggest that this functional transporter polymorphi..... More Our data suggest that this functional transporter polymorphism does not seem to play a major role in the genetics of bipolar disorder and major depression in Brazilian patients. Less	Negative
12763299	Cross-disorder study	In summary, we found an association between the less active ..... More In summary, we found an association between the less active form of polymorphism in the serotonin transporter gene and bipolar or unipolar affective illness. Less	Positive
8904780	Cross-disorder study	No significant differences were found in major depression gr..... More No significant differences were found in major depression groups. Less	Negative

BDNF

37(24/12/1)

21438144	Cross-disorder study	No significant association of this gene was observed in MDD...... More No significant association of this gene was observed in MDD. Less	Negative
14673216	Cross-disorder study	Given the fact that the positive association between BDNF ge..... More Given the fact that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or our Chinese sample, it appears likely that this association is ethnicity dependent. Less	Negative

16005437

Cross-disorder study

Our findings suggest that BDNF may be a susceptibility gene ..... More

Positive

COMT

28(14/14/0)

15583702	Cross-disorder study	No association emerged between MDD cases and control subject..... More No association emerged between MDD cases and control subjects.But an association was found between the high-activity COMT Val allele, particularly the COMT Val/Val genotype and EO-MDD. Less	Negative
21600957	Cross-disorder study	In conclusion, we partially replicated our previous findings..... More In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes. Less	Positive

25766270	Cross-disorder study	This work first showed the association of combined Leu136Leu..... More This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD. Less	Positive
16232322	Cross-disorder study	Our results support the view that COMT variation provides a ..... More Our results support the view that COMT variation provides a weak general predisposition to neuropsychiatric disease including psychotic and affective disorders.One SNP was marginally associated in the major depressive group. Less	Positive
16969269	Cross-disorder study	COMT variants were not a major liability factor for mood dis..... More COMT variants were not a major liability factor for mood disorder and for mood disorder symptomatology in the present sample. Less	Negative
9270905	Cross-disorder study	We conclude that genetic variation that determines high and ..... More We conclude that genetic variation that determines high and low activities of COMT does not have a major effect on the vulnerability to affective disorders in our sample. Less	Negative
9631418	Cross-disorder study	Our results suggest the COMTL allele contributed to the etio..... More Our results suggest the COMTL allele contributed to the etiologies of depressive disorders. Less	Positive

DRD2

28(8/20/0)

21292452	Cross-disorder study	Polymorphisms of NR3C1 gene analyzed in this study may modif..... More Polymorphisms of NR3C1 gene analyzed in this study may modify susceptibility to major depressive disorder Less	Positive
11857579	Cross-disorder study	No association was found for DRD2 in UPAD.	Negative

9754623	Cross-disorder study	These results do not support a major role for the DRD2 gene ..... More These results do not support a major role for the DRD2 gene in the etiology of either bipolar or unipolar affective disorders. Less	Negative
10889529	Cross-disorder study	No significant association was observed in MDD.	Negative
21130502	Cross-disorder study	This meta-analysis suggests that mood disorders may not be a..... More This meta-analysis suggests that mood disorders may not be associated with DRD2 polymorphism, Ser311/Cys311. Less	Negative
8882909	Cross-disorder study	Our results suggest that there is a significant association ..... More Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Less	Negative

DAOA

21(13/7/1)

21438144	Cross-disorder study	Significant associations of this gene were found in MDD pati..... More Significant associations of this gene were found in MDD patients. Less	Positive
24447945	Cross-disorder study	DAOA genetic polymorphisms (M15, M18 andM23) were not found ..... More DAOA genetic polymorphisms (M15, M18 andM23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis. Less	Negative

MAOA

21(10/11/0)

9342198	Cross-disorder study	Therefore, our results did not support the involvement of th..... More Therefore, our results did not support the involvement of the alleles at MAOA and MAOB in the etiology of mood disorder. Less	Negative
15564894	Cross-disorder study	An increase of high-activity uMAOA alleles was found in majo..... More An increase of high-activity uMAOA alleles was found in major depression female patients presenting a seasonal pattern (X<sup>2</sup>=3.013, P-value = 0.05) or psychotic symptoms in their episodes (X<sup>2</sup>=2.679, P-value = 0.07).. Our results suggest that MAOA gene variation may modulate the expression of some clinical aspects of severe mood disorders, especially in females, and support the existence of a genetic and aetiologic heterogeneity underlying the diagnoses of bipolar disorder and major depression. Less	Positive

11304831	Cross-disorder study	Our results suggest that there is no association between MAO..... More Our results suggest that there is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in our population. Less	Negative
10483059	Cross-disorder study	There was no significant genotypic or allelic association, s..... More There was no significant genotypic or allelic association, suggesting that the functional VNTR polymorphism in the MAOA gene is unlikely to play a major role in the pathogenesis of bipolar disorder or unipolar depression. Less	Negative
20010318	Cross-disorder study	Our meta-analysis suggests a significant association of the ..... More Our meta-analysis suggests a significant association of the MAOA gene with major depressive disorder and BPD within specific groups Less	Positive
10686545	Cross-disorder study	As for association studies, no significant association betwe..... More As for association studies, no significant association between unipolar disorder and MAOA gene was detected. Less	Negative
10402508	Cross-disorder study	No significant association was found between MAOA gene and U..... More No significant association was found between MAOA gene and Unipolar patients. Less	Negative

CACNA1C

20(17/3/0)

20351715	Cross-disorder study	In conclusion, this analysis provides support for a role of ..... More In conclusion, this analysis provides support for a role of CACNA1C risk variants for both bipolar and unipolar major mood disorders. Less	Positive
19621016	Cross-disorder study	The risk allele rs1006737 in this gene conferred increased r..... More The risk allele rs1006737 in this gene conferred increased risk for recurrent major depression (P= 0.013) with similar effect sizes to those previously observed in BD (allelic odds ratio B1.15). Less	Positive

23453885	Cross-disorder study	Significant association was observed in cross-disorder analy..... More Significant association was observed in cross-disorder analysis. Less	Positive
23680436	Cross-disorder study	No significant association was found between MDD and this ge..... More No significant association was found between MDD and this gene. Less	Negative
25843436	Cross-disorder study	no significant differences were observed in this study.	Negative

DISC1

18(10/7/1)

19255581	Cross-disorder study	a haplotypic association was found for both BD and MDD.	Positive
18075479	Cross-disorder study	no SNP or haplotype of the DISC1 gene is associated with uni..... More no SNP or haplotype of the DISC1 gene is associated with unipolar disorder in the Japanese population. Less	Negative

16(4/12/0)

10050974	Cross-disorder study	A weak association (chi2 = 3.946, 1 df, P = 0.047; odds rati..... More A weak association (chi2 = 3.946, 1 df, P = 0.047; odds ratio, allele 2 vs. allele 1 = 0.71 (95% CI, 0.51-0.996)) was observed in the unipolar sample with the TH-PstI polymorphism.Our data suggest that this locus should be examined in larger samples of unipolar affective disorder. Less	Positive
9129719	Cross-disorder study	Therefore, the hypothesis that the tyrosine hydroxylase and ..... More Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study. Less	Negative

8871780

Cross-disorder study

The observed excess of homozygosity may indicate that a rece..... More

Positive

MTHFR

16(10/6/0)

15564899	Cross-disorder study	There was no significant difference in genotype distribution..... More There was no significant difference in genotype distributions or allele frequencies of the MTHFR 667C>T polymorphism between controls and any of the diagnostic groups. Less	Negative
9342205	Cross-disorder study	The genotype homozygous for the T677 allele was significantl..... More The genotype homozygous for the T677 allele was significantly frequently observed in schizophrenics with an odds ratio of 1.9 (P = 0.0006), and in patients with major depression with an odds ratio of 2.8 (P = 0.005). Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese. Less	Positive

16691128	Cross-disorder study	The meta-analysis results suggested that east Asians have a ..... More The meta-analysis results suggested that east Asians have a greater genetic risk from the MTHFR gene in developing schizophrenia and depression, and that the genetic effects in bipolar disorder and depression are different. A further exploration of the involvement of the MTHFR gene in the susceptibility to schizophrenia and affective disorders, with a greater number of studies with larger sample sizes, however, are needed to fully establish the role of the MTHFR gene. Less	Positive
17074966	Cross-disorder study	For unipolar depression and the MTHFR C677T polymorphism, th..... More For unipolar depression and the MTHFR C677T polymorphism, the fixed-effects odds ratio for homozygote variants (TT) versus the wild type (CC) was 1.36 (95%confidence interval (CI): 1.11, 1.67), with no residual between-study heterogeneity (I<sup>2</sup>= 0%)â€”based on 1, 280 cases and 10, 429 controls. . These results were robust to various sensitively analyses. This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention. Less	Positive
16055253	Cross-disorder study	The 1298C variant was significantly associated with both Bip..... More The 1298C variant was significantly associated with both Bip and MD arguing that variation in the MTHFR gene contributes to the genetic risk for affective psychoses. Less	Positive
9774778	Cross-disorder study	Our results suggest that homozygosity for the T677 allele of..... More Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample. Less	Negative

TPH2

13(10/3/0)

17604842	Cross-disorder study	No association was detected between the rs4131347 (?C8347G) ..... More No association was detected between the rs4131347 (?C8347G) SNP in the promoter region of the TPH2 gene and mood disorders Less	Negative
17015812	Cross-disorder study	Haplotype-based analysis of TPH2 in patients with UP and BP ..... More Haplotype-based analysis of TPH2 in patients with UP and BP disorder and controls from northern Swedish descent provides preliminary evidence for protective association in both disorders and thus supports a central role for TPH2 in the pathogenesis of affective disorders. Less	Positive

DRD4

13(1/12/0)

9129719	Cross-disorder study	Therefore, the hypothesis that the tyrosine hydroxylase and ..... More Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study. Less	Negative
8882909	Cross-disorder study	Our results suggest that there is a significant association ..... More Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Less	Positive

15860340	Cross-disorder study	These findings suggest that the DRD4.2 allele is a risk alle..... More These findings suggest that the DRD4.2 allele is a risk allele for depression symptomatology. Less	Positive
11353451	Cross-disorder study	Major depressives showed a trend toward an excess of DRD4Sh..... More Major depressives showed a trend toward an excess of DRD4Short and DRD4*Short/Short variants versus controls. Less	Positive

CLOCK

12(5/7/0)

19224106	Cross-disorder study	No significant association was found with MDD.	Negative
20072116	Cross-disorder study	Significant associations of CLOCK gene were found in MDD pat..... More Significant associations of CLOCK gene were found in MDD patients. Less	Positive

22080789	Cross-disorder study	We did not detect any associations between tagging SNPs in C..... More We did not detect any associations between tagging SNPs in CLOCK and BP or MDD Less	Negative
24687905	Cross-disorder study	P-value=0.54. Gene-based tests show no significant associati..... More P-value=0.54. Gene-based tests show no significant association between this gene and MDD. Less	Negative

P2RX7

9(2/7/0)

19330776	Cross-disorder study	we observed no significant differences between German Mdd-U..... More we observed no significant differences between German Mdd-UP samples and German control. Less	Negative
23602648	Cross-disorder study	In the case-control analysis we did not find any significant..... More In the case-control analysis we did not find any significant differences between genotype frequencies of either BPD or MDD cases and controls. Our genetic association study supports the association between P2RX7 gene and severity of depressive symptoms in BPD patients. Less	Negative

21438144	Cross-disorder study	Significant associations of this gene were found in MDD pati..... More Significant associations of this gene were found in MDD patients. Less	Positive
18543274	Cross-disorder study	In conclusion, case-control analysis did not reveal signific..... More In conclusion, case-control analysis did not reveal significant results, but using a symptomseverity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene. Less	Positive

DTNBP1

8(4/3/1)

19089808

Cross-disorder study

When we compared the subset of bipolar cases diagnosed with ..... More

Positive

WFS1

7(1/6/0)

10760554	Cross-disorder study	It is not likely that WFS1 mutations are responsible for as ..... More It is not likely that WFS1 mutations are responsible for as much as 25% of depressive illness. Less	Negative
15473915	Cross-disorder study	In conclusion, our study supports the role of the WFS1 gene ..... More In conclusion, our study supports the role of the WFS1 gene in susceptibility for MDD and BPD. By means of haplotype analysis we were able to define the GTA haplotype in the WFS1 gene related to an increased risk for mood disorders. Less	Positive

10624825	Cross-disorder study	Statistical analyses of allele or genotype frequencies do no..... More Statistical analyses of allele or genotype frequencies do not support a major role for wolframin in affective disorder. Less	Negative
25074416	Cross-disorder study	There is no association between WFS1 gene H611R polymorphism..... More There is no association between WFS1 gene H611R polymorphism and mood disorders. Less	Negetive

PER2

7(1/6/0)

24687905	Cross-disorder study	P-value=0.67. Gene-based tests show no significant associati..... More P-value=0.67. Gene-based tests show no significant association between this gene and MDD. Less	Negative
20072116	Cross-disorder study	No significant associations of PER2 gene were found in MDD p..... More No significant associations of PER2 gene were found in MDD patients. Less	Positive

GRM3

7(3/4/0)

19386277

Cross-disorder study

We detected an association between only onemarker (rs6465084..... More

Positive

PER3

7(3/4/0)

20072116	Cross-disorder study	Significant associations of PER3 gene were found in MDD pati..... More Significant associations of PER3 gene were found in MDD patients. Less	Positive
24687905	Cross-disorder study	P-value=0.64. Gene-based tests show no significant associati..... More P-value=0.64. Gene-based tests show no significant association between this gene and MDD. Less	Negative

ARNTL

7(5/2/0)

24687905	Cross-disorder study	P-value=0.51. Gene-based tests show no significant associati..... More P-value=0.51. Gene-based tests show no significant association between this gene and MDD. Less	Negative
20072116	Cross-disorder study	Significant associations of ARNTL gene were found in MDD pat..... More Significant associations of ARNTL gene were found in MDD patients. Less	Positive

HTR2C

7(4/3/0)

11526472

Cross-disorder study

In conclusion, we have found that both major depression and ..... More

Positive

SYNE1

6(3/2/1)

23453885	Cross-disorder study
22565781	Cross-disorder study	Our findings add to the evidence that association at this lo..... More Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders. Less	Positive

NR1D1

6(2/4/0)

24687905	Cross-disorder study	P-value=0.03. The NR1D1 gene was the only circadian gene to ..... More P-value=0.03. The NR1D1 gene was the only circadian gene to show nominal significancewith major depression(P=0.03). Less	Negative
20072116	Cross-disorder study	No significant associations of NR1D1 gene were found in MDD ..... More No significant associations of NR1D1 gene were found in MDD patients. Less	Positive

GABRA5

6(6/0/0)

9267853	Cross-disorder study	ln the view of these observations, our data could be explain..... More ln the view of these observations, our data could be explained by assuming that allele 4 of the GABRA5 gene polymorphism confers a higher risk to UPR major depression but not necessarily to BPI disorder which combines major depression with manic episodes. Less	Positive
9514592	Cross-disorder study	The distribution of allelic frequencies of the GABRA5 locus ..... More The distribution of allelic frequencies of the GABRA5 locus differed significantly between BP patients and controls with the 282-bp allele found to be associated with BP affective disorder, while no such difference was observed between the groups of UP patients and controls nor between the two patient groups. Less	Positive

TAAR6

5(4/1/0)

19582769

Cross-disorder study

A significant predictive value of specific interactions betw..... More

Positive

NPAS2

5(3/2/0)

20072116	Cross-disorder study	Significant associations of NPAS2 gene were found in MDD pat..... More Significant associations of NPAS2 gene were found in MDD patients. Less	Positive
24687905	Cross-disorder study	P-value=0.39. Gene-based tests show no significant associati..... More P-value=0.39. Gene-based tests show no significant association between this gene and MDD. Less	Negative

PBRM1

5(4/0/1)

20081856

Cross-disorder study

A synonymous variant in the gene PBRM1 was significant in ma..... More

Positive

FKBP5

5(1/4/0)

24856550

Cross-disorder study

Our main finding is an association of FKBP5 polymorphisms (r..... More

Positive

ACE

5(2/3/0)

11121171	Cross-disorder study	These results do not support the ACE gene having a major rol..... More These results do not support the ACE gene having a major role in the etiology of either bipolar or unipolar affective disorders. Less	Negative
8931914	Cross-disorder study	The D allele was significantly more frequent in the patients..... More The D allele was significantly more frequent in the patients with major depression than in the controls, and the DD genotype was significantly more frequent in the patients with major depression than in the controls. Less	Positive

TSNAX

4(3/1/0)

19760522	Cross-disorder study	We did not find any association between TSNAX and MDD in the..... More We did not find any association between TSNAX and MDD in the allele/genotype analysis or haplotype analysis. Less	Negative
19255581	Cross-disorder study	A haplotypic association was found for both BD and MDD	Positive

CRHR1

4(2/2/0)

23962971

Cross-disorder study

Polymorphisms of CRHR1 and AVPR1b may modify susceptibility ..... More

Positive

AVPR1B

4(3/1/0)

23962971

Cross-disorder study

Polymorphisms of CRHR1 and AVPR1b may modify susceptibility ..... More

Positive

CACNB2

3(2/1/0)

23453885

Cross-disorder study

Significant association was observed in cross-disorder analy..... More

Positive

HTR1A

3(2/1/0)

22752684

Cross-disorder study

Results from this expanded meta-analysis, which included our..... More

Positive

GPR50

3(2/1/0)

15452587	Cross-disorder study	We have shown that GPR50 is a strong candidate gene for fema..... More We have shown that GPR50 is a strong candidate gene for female-associated affective disorder. Less	Positive
20371266	Cross-disorder study	No polymorphism was significantly associated with MDD.	Negative

CRHR2

3(2/1/0)

11857585

Cross-disorder study

Significant associations of CRHR2 1047G/A were found in MDD.

Positive

ADCYAP1

3(1/2/0)

20072116

Cross-disorder study

Significant associations of ADCYAP1 gene were found in MDD p..... More

Positive

ARNTL2

3(1/2/0)

20072116	Cross-disorder study	Significant associations of ARNTL2 gene were found in MDD pa..... More Significant associations of ARNTL2 gene were found in MDD patients. Less	Positive
24687905	Cross-disorder study	P-value=0.95. Gene-based tests show no significant associati..... More P-value=0.95. Gene-based tests show no significant association between this gene and MDD. Less	Negative

ITIH3

3(3/0/0)

23453885

Cross-disorder study

Significant association was observed in cross-disorder analy..... More

Positive

GNL3

2(2/0/0)

20081856

Cross-disorder study

A nonsynonymous variant in the gene GNL3 was significant in ..... More

Positive

HSPA1A

2(2/0/0)

19582769

Cross-disorder study

A significant predictive value of specific interactions betw..... More

Positive

ABCA13

2(2/0/0)

19944402

Cross-disorder study

The frequency of all rare variants combined was greater than..... More

Positive

HTR4

2(1/1/0)

12399948

Cross-disorder study

These findings suggest that genomic variations in the HTR4 g..... More

Positive

CRY1

2(1/1/0)

20072116

Cross-disorder study

Significant associations of CRY1 gene were found in MDD pati..... More

Positive

NOS3

2(1/1/0)

15967063

Cross-disorder study

MD was not found to be significantly associated with NOS3 af..... More

Positive

BCR

2(1/1/0)

15866548

Cross-disorder study

Our results suggest that genetic variations in the BCR gene ..... More

Positive

CTLA4

2(1/1/0)

21040781

Cross-disorder study

Our results suggest that shared common risk factors for schi..... More

Positive

CSF2RB

2(1/1/0)

21247258

Cross-disorder study

Our results support CSF2RB as a risk factor common to both s..... More

Positive

BCL9

1(1/0/0)

21383261

Cross-disorder study

These findings indicate that common variations in the BCL9 g..... More

Positive

GRIK3

1(1/0/0)

16958029

Cross-disorder study

TDT <sub>linkage</sub> P-value = 0.011, RR (95% ..... More

Positive

AS3MT

1(1/0/0)

23453885

Cross-disorder study

Significant association was observed in cross-disorder analy..... More

Positive

VIPR2

1(1/0/0)

20072116

Cross-disorder study

Significant associations of VIPR2 gene were found in MDD pat..... More

Positive

CCDC68

1(1/0/0)

23453885

Cross-disorder study

Significant association was observed in cross-disorder analy..... More

Positive

PROKR2

1(1/0/0)

19544013

Cross-disorder study

In conclusion, our results suggest that PROKR2 probably play..... More

Positive

From candidate gene intersection analysis (count: 35)

Gene Symbol

No. of Studies (Positive/Negative/Trend) for BD

No. of Studies for MDD

Overlap with MDD

Reference	Source	Description (MK4MDD Link)	Category

SLC6A4

44(18/26/0)

9322234	Cross-disorder study	Our finding that the deleted allele of 5-HTTLPR is significa..... More Our finding that the deleted allele of 5-HTTLPR is significantly less common in lithium-treated unipolar probands than in controls may reflect a genuine drug response effect of this polymorphism or may simply reflect sampling variance. Less	Positive
9149321	Cross-disorder study	There was a significant difference between patients with uni..... More There was a significant difference between patients with unipolar disorder and controls in the proportion of individuals carrying the STin2.9 allele.The findings support the hypothesis that allelic variation in the serotonin transporter gene may contribute to susceptibility for both major depression and bipolar disorder. Less	Positive

9399688	Cross-disorder study	No significant association with unipolar depression was dete..... More No significant association with unipolar depression was detected using either genetic marker. Less	Negative
9514589	Cross-disorder study	These results suggest that the promoter allele 2 of 5-HTT, w..... More These results suggest that the promoter allele 2 of 5-HTT, which has previously been shown to result in lower levels of serotonin transporter transcription, may be associated with affective disorder risk. Less	Positive
21438144	Cross-disorder study	Significant associations of this gene were found in MDD pati..... More Significant associations of this gene were found in MDD patients. Less	Positive
11803453	Cross-disorder study	No significant association of 5HTTLPR was observed in MDD.	Negative
11240581	Cross-disorder study	No association related to the polymorphism was found in the ..... More No association related to the polymorphism was found in the promoter region of the serotonin transporter gene. Less	Negative
10780268	Cross-disorder study	Thus, we conclude that the SERT VNTR polymorphism may be a r..... More Thus, we conclude that the SERT VNTR polymorphism may be a risk factor for both schizophrenia and unipolar depression, but not for bipolar disorder, in the Han Chinese. Less	Positive
9514579	Cross-disorder study	our data suggest that the 5-HTT gene is not commonly involve..... More our data suggest that the 5-HTT gene is not commonly involved in the susceptibility to mood disorders. Less	Negative
10889543	Cross-disorder study	Our data suggest that this functional transporter polymorphi..... More Our data suggest that this functional transporter polymorphism does not seem to play a major role in the genetics of bipolar disorder and major depression in Brazilian patients. Less	Negative
12763299	Cross-disorder study	In summary, we found an association between the less active ..... More In summary, we found an association between the less active form of polymorphism in the serotonin transporter gene and bipolar or unipolar affective illness. Less	Positive
8904780	Cross-disorder study	No significant differences were found in major depression gr..... More No significant differences were found in major depression groups. Less	Negative

BDNF

37(24/12/1)

21438144	Cross-disorder study	No significant association of this gene was observed in MDD...... More No significant association of this gene was observed in MDD. Less	Negative
14673216	Cross-disorder study	Given the fact that the positive association between BDNF ge..... More Given the fact that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or our Chinese sample, it appears likely that this association is ethnicity dependent. Less	Negative

16005437

Cross-disorder study

Our findings suggest that BDNF may be a susceptibility gene ..... More

Positive

COMT

28(14/14/0)

15583702	Cross-disorder study	No association emerged between MDD cases and control subject..... More No association emerged between MDD cases and control subjects.But an association was found between the high-activity COMT Val allele, particularly the COMT Val/Val genotype and EO-MDD. Less	Negative
21600957	Cross-disorder study	In conclusion, we partially replicated our previous findings..... More In conclusion, we partially replicated our previous findings confirming a possible influence of COMT variants in MD and BD, particularly in early onset subjects, though not with the same risk genotypes. Less	Positive

25766270	Cross-disorder study	This work first showed the association of combined Leu136Leu..... More This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD. Less	Positive
16232322	Cross-disorder study	Our results support the view that COMT variation provides a ..... More Our results support the view that COMT variation provides a weak general predisposition to neuropsychiatric disease including psychotic and affective disorders.One SNP was marginally associated in the major depressive group. Less	Positive
16969269	Cross-disorder study	COMT variants were not a major liability factor for mood dis..... More COMT variants were not a major liability factor for mood disorder and for mood disorder symptomatology in the present sample. Less	Negative
9270905	Cross-disorder study	We conclude that genetic variation that determines high and ..... More We conclude that genetic variation that determines high and low activities of COMT does not have a major effect on the vulnerability to affective disorders in our sample. Less	Negative
9631418	Cross-disorder study	Our results suggest the COMTL allele contributed to the etio..... More Our results suggest the COMTL allele contributed to the etiologies of depressive disorders. Less	Positive

DRD2

28(8/20/0)

21292452	Cross-disorder study	Polymorphisms of NR3C1 gene analyzed in this study may modif..... More Polymorphisms of NR3C1 gene analyzed in this study may modify susceptibility to major depressive disorder Less	Positive
11857579	Cross-disorder study	No association was found for DRD2 in UPAD.	Negative

9754623	Cross-disorder study	These results do not support a major role for the DRD2 gene ..... More These results do not support a major role for the DRD2 gene in the etiology of either bipolar or unipolar affective disorders. Less	Negative
10889529	Cross-disorder study	No significant association was observed in MDD.	Negative
21130502	Cross-disorder study	This meta-analysis suggests that mood disorders may not be a..... More This meta-analysis suggests that mood disorders may not be associated with DRD2 polymorphism, Ser311/Cys311. Less	Negative
8882909	Cross-disorder study	Our results suggest that there is a significant association ..... More Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Less	Negative

DAOA

21(13/7/1)

21438144	Cross-disorder study	Significant associations of this gene were found in MDD pati..... More Significant associations of this gene were found in MDD patients. Less	Positive
24447945	Cross-disorder study	DAOA genetic polymorphisms (M15, M18 andM23) were not found ..... More DAOA genetic polymorphisms (M15, M18 andM23) were not found to confer a statistically significant increased risk of SCZ, BD or DD in the overall sample, or in Caucasians and Asians following subgroup analysis. Less	Negative

MAOA

21(10/11/0)

9342198	Cross-disorder study	Therefore, our results did not support the involvement of th..... More Therefore, our results did not support the involvement of the alleles at MAOA and MAOB in the etiology of mood disorder. Less	Negative
15564894	Cross-disorder study	An increase of high-activity uMAOA alleles was found in majo..... More An increase of high-activity uMAOA alleles was found in major depression female patients presenting a seasonal pattern (X<sup>2</sup>=3.013, P-value = 0.05) or psychotic symptoms in their episodes (X<sup>2</sup>=2.679, P-value = 0.07).. Our results suggest that MAOA gene variation may modulate the expression of some clinical aspects of severe mood disorders, especially in females, and support the existence of a genetic and aetiologic heterogeneity underlying the diagnoses of bipolar disorder and major depression. Less	Positive

11304831	Cross-disorder study	Our results suggest that there is no association between MAO..... More Our results suggest that there is no association between MAOA-LPR genotype and susceptibility to recurrent major depression, bipolar disorder, and schizophrenia in our population. Less	Negative
10483059	Cross-disorder study	There was no significant genotypic or allelic association, s..... More There was no significant genotypic or allelic association, suggesting that the functional VNTR polymorphism in the MAOA gene is unlikely to play a major role in the pathogenesis of bipolar disorder or unipolar depression. Less	Negative
20010318	Cross-disorder study	Our meta-analysis suggests a significant association of the ..... More Our meta-analysis suggests a significant association of the MAOA gene with major depressive disorder and BPD within specific groups Less	Positive
10686545	Cross-disorder study	As for association studies, no significant association betwe..... More As for association studies, no significant association between unipolar disorder and MAOA gene was detected. Less	Negative
10402508	Cross-disorder study	No significant association was found between MAOA gene and U..... More No significant association was found between MAOA gene and Unipolar patients. Less	Negative

DISC1

18(10/7/1)

19255581	Cross-disorder study	a haplotypic association was found for both BD and MDD.	Positive
18075479	Cross-disorder study	no SNP or haplotype of the DISC1 gene is associated with uni..... More no SNP or haplotype of the DISC1 gene is associated with unipolar disorder in the Japanese population. Less	Negative

MTHFR

16(10/6/0)

15564899	Cross-disorder study	There was no significant difference in genotype distribution..... More There was no significant difference in genotype distributions or allele frequencies of the MTHFR 667C>T polymorphism between controls and any of the diagnostic groups. Less	Negative
9342205	Cross-disorder study	The genotype homozygous for the T677 allele was significantl..... More The genotype homozygous for the T677 allele was significantly frequently observed in schizophrenics with an odds ratio of 1.9 (P = 0.0006), and in patients with major depression with an odds ratio of 2.8 (P = 0.005). Our data suggest associations of the MTHFR gene variant with schizophrenia and depression in the Japanese. Less	Positive

16691128	Cross-disorder study	The meta-analysis results suggested that east Asians have a ..... More The meta-analysis results suggested that east Asians have a greater genetic risk from the MTHFR gene in developing schizophrenia and depression, and that the genetic effects in bipolar disorder and depression are different. A further exploration of the involvement of the MTHFR gene in the susceptibility to schizophrenia and affective disorders, with a greater number of studies with larger sample sizes, however, are needed to fully establish the role of the MTHFR gene. Less	Positive
17074966	Cross-disorder study	For unipolar depression and the MTHFR C677T polymorphism, th..... More For unipolar depression and the MTHFR C677T polymorphism, the fixed-effects odds ratio for homozygote variants (TT) versus the wild type (CC) was 1.36 (95%confidence interval (CI): 1.11, 1.67), with no residual between-study heterogeneity (I<sup>2</sup>= 0%)â€”based on 1, 280 cases and 10, 429 controls. . These results were robust to various sensitively analyses. This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention. Less	Positive
16055253	Cross-disorder study	The 1298C variant was significantly associated with both Bip..... More The 1298C variant was significantly associated with both Bip and MD arguing that variation in the MTHFR gene contributes to the genetic risk for affective psychoses. Less	Positive
9774778	Cross-disorder study	Our results suggest that homozygosity for the T677 allele of..... More Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample. Less	Negative

TPH2

13(10/3/0)

17604842	Cross-disorder study	No association was detected between the rs4131347 (?C8347G) ..... More No association was detected between the rs4131347 (?C8347G) SNP in the promoter region of the TPH2 gene and mood disorders Less	Negative
17015812	Cross-disorder study	Haplotype-based analysis of TPH2 in patients with UP and BP ..... More Haplotype-based analysis of TPH2 in patients with UP and BP disorder and controls from northern Swedish descent provides preliminary evidence for protective association in both disorders and thus supports a central role for TPH2 in the pathogenesis of affective disorders. Less	Positive

DRD4

13(1/12/0)

9129719	Cross-disorder study	Therefore, the hypothesis that the tyrosine hydroxylase and ..... More Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study. Less	Negative
8882909	Cross-disorder study	Our results suggest that there is a significant association ..... More Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Less	Positive

15860340	Cross-disorder study	These findings suggest that the DRD4.2 allele is a risk alle..... More These findings suggest that the DRD4.2 allele is a risk allele for depression symptomatology. Less	Positive
11353451	Cross-disorder study	Major depressives showed a trend toward an excess of DRD4Sh..... More Major depressives showed a trend toward an excess of DRD4Short and DRD4*Short/Short variants versus controls. Less	Positive

CLOCK

12(5/7/0)

19224106	Cross-disorder study	No significant association was found with MDD.	Negative
20072116	Cross-disorder study	Significant associations of CLOCK gene were found in MDD pat..... More Significant associations of CLOCK gene were found in MDD patients. Less	Positive

22080789	Cross-disorder study	We did not detect any associations between tagging SNPs in C..... More We did not detect any associations between tagging SNPs in CLOCK and BP or MDD Less	Negative
24687905	Cross-disorder study	P-value=0.54. Gene-based tests show no significant associati..... More P-value=0.54. Gene-based tests show no significant association between this gene and MDD. Less	Negative

P2RX7

9(2/7/0)

19330776	Cross-disorder study	we observed no significant differences between German Mdd-U..... More we observed no significant differences between German Mdd-UP samples and German control. Less	Negative
23602648	Cross-disorder study	In the case-control analysis we did not find any significant..... More In the case-control analysis we did not find any significant differences between genotype frequencies of either BPD or MDD cases and controls. Our genetic association study supports the association between P2RX7 gene and severity of depressive symptoms in BPD patients. Less	Negative

21438144	Cross-disorder study	Significant associations of this gene were found in MDD pati..... More Significant associations of this gene were found in MDD patients. Less	Positive
18543274	Cross-disorder study	In conclusion, case-control analysis did not reveal signific..... More In conclusion, case-control analysis did not reveal significant results, but using a symptomseverity scale we could support the association between depressive disorder and the G-allele of the Gln460Arg polymorphism in the P2RX7 gene. Less	Positive

DTNBP1

8(4/3/1)

19089808

Cross-disorder study

When we compared the subset of bipolar cases diagnosed with ..... More

Positive

WFS1

7(1/6/0)

10760554	Cross-disorder study	It is not likely that WFS1 mutations are responsible for as ..... More It is not likely that WFS1 mutations are responsible for as much as 25% of depressive illness. Less	Negative
15473915	Cross-disorder study	In conclusion, our study supports the role of the WFS1 gene ..... More In conclusion, our study supports the role of the WFS1 gene in susceptibility for MDD and BPD. By means of haplotype analysis we were able to define the GTA haplotype in the WFS1 gene related to an increased risk for mood disorders. Less	Positive

10624825	Cross-disorder study	Statistical analyses of allele or genotype frequencies do no..... More Statistical analyses of allele or genotype frequencies do not support a major role for wolframin in affective disorder. Less	Negative
25074416	Cross-disorder study	There is no association between WFS1 gene H611R polymorphism..... More There is no association between WFS1 gene H611R polymorphism and mood disorders. Less	Negetive

GRM3

7(3/4/0)

19386277

Cross-disorder study

We detected an association between only onemarker (rs6465084..... More

Positive

HTR2C

7(4/3/0)

11526472

Cross-disorder study

In conclusion, we have found that both major depression and ..... More

Positive

SYNE1

6(3/2/1)

23453885	Cross-disorder study
22565781	Cross-disorder study	Our findings add to the evidence that association at this lo..... More Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders. Less	Positive

NR1D1

6(2/4/0)

24687905	Cross-disorder study	P-value=0.03. The NR1D1 gene was the only circadian gene to ..... More P-value=0.03. The NR1D1 gene was the only circadian gene to show nominal significancewith major depression(P=0.03). Less	Negative
20072116	Cross-disorder study	No significant associations of NR1D1 gene were found in MDD ..... More No significant associations of NR1D1 gene were found in MDD patients. Less	Positive

GABRA5

6(6/0/0)

9267853	Cross-disorder study	ln the view of these observations, our data could be explain..... More ln the view of these observations, our data could be explained by assuming that allele 4 of the GABRA5 gene polymorphism confers a higher risk to UPR major depression but not necessarily to BPI disorder which combines major depression with manic episodes. Less	Positive
9514592	Cross-disorder study	The distribution of allelic frequencies of the GABRA5 locus ..... More The distribution of allelic frequencies of the GABRA5 locus differed significantly between BP patients and controls with the 282-bp allele found to be associated with BP affective disorder, while no such difference was observed between the groups of UP patients and controls nor between the two patient groups. Less	Positive

NPAS2

5(3/2/0)

20072116	Cross-disorder study	Significant associations of NPAS2 gene were found in MDD pat..... More Significant associations of NPAS2 gene were found in MDD patients. Less	Positive
24687905	Cross-disorder study	P-value=0.39. Gene-based tests show no significant associati..... More P-value=0.39. Gene-based tests show no significant association between this gene and MDD. Less	Negative

FKBP5

5(1/4/0)

24856550

Cross-disorder study

Our main finding is an association of FKBP5 polymorphisms (r..... More

Positive

ACE

5(2/3/0)

11121171	Cross-disorder study	These results do not support the ACE gene having a major rol..... More These results do not support the ACE gene having a major role in the etiology of either bipolar or unipolar affective disorders. Less	Negative
8931914	Cross-disorder study	The D allele was significantly more frequent in the patients..... More The D allele was significantly more frequent in the patients with major depression than in the controls, and the DD genotype was significantly more frequent in the patients with major depression than in the controls. Less	Positive

TSNAX

4(3/1/0)

19760522	Cross-disorder study	We did not find any association between TSNAX and MDD in the..... More We did not find any association between TSNAX and MDD in the allele/genotype analysis or haplotype analysis. Less	Negative
19255581	Cross-disorder study	A haplotypic association was found for both BD and MDD	Positive

CRHR1

4(2/2/0)

23962971

Cross-disorder study

Polymorphisms of CRHR1 and AVPR1b may modify susceptibility ..... More

Positive

AVPR1B

4(3/1/0)

23962971

Cross-disorder study

Polymorphisms of CRHR1 and AVPR1b may modify susceptibility ..... More

Positive

HTR1A

3(2/1/0)

22752684

Cross-disorder study

Results from this expanded meta-analysis, which included our..... More

Positive

GPR50

3(2/1/0)

15452587	Cross-disorder study	We have shown that GPR50 is a strong candidate gene for fema..... More We have shown that GPR50 is a strong candidate gene for female-associated affective disorder. Less	Positive
20371266	Cross-disorder study	No polymorphism was significantly associated with MDD.	Negative