BDgene

Study Report

Basic Info
Reference
Citation Serretti, A., R. Lilli, et al. (2001). "DRD4 exon 3 variants associated with delusional symptomatology in major psychoses: a study on 2,011 affected subjects." Am J Med Genet 105(3): 283-290.
Disease Type Bipolar Disorder & Schizophrenia & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 2,011 inpatients affected by bipolar disorder (n = 811), major depressive disorder (n = 635), schizophrenia (n = 419), delusional disorder (n = 104), psychotic disorder not otherwise specified (n = 42), and 601 healthy controls
SNP/Region/Marker Size 1 variant
Predominant Ethnicity Caucasian
Population Italian
Gender 42% males in patients and 44% males in controls
Age Group Adults : Mean age(SD)(year):45.92(14.44);31.41(12.42) at onset for BD patients and 47.45(14.96) for controls

Detail Info

Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
SZ DRD4 exon3 VNTR DRD4 VNTR Association analysis:chi sauqre test, all P-value > 0.05 No significant association was observed in SZ. Negative
MDD DRD4 exon3 VNTR DRD4 VNTR Association analysis:chi sauqre test, allele DRD4*Short variants, chi square=6.38, d.f.=1, P-value = 0.012;genotype DRD4*Short/Short, chi square=11.88, df=2, P-value = 0.002 Significant associations were found in MDD patients. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
SZ DRD4 DRD4 allele and genotype frequencies in schizophrenics were not significantly different from controls. Negative
MDD DRD4 Major depressives showed a trend toward an excess of DRD4*Short and DRD4*Short/Short variants versus controls. Positive