Study Report

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Basic Info

Reference	Soria, V.,2010 PMID: 20072116
Citation	Soria, V., E. Martinez-Amoros, et al. (2010). "Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder." Neuropsychopharmacology 35(6): 1279-1289.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	335 MDD patients, 199 BD patients and 440 unrelated controls
SNP/Region/Marker Size	248 SNPs
Predominant Ethnicity	Caucasian
Population	Spanish
Gender	female: 67.4% for patients,47.5% for controls
Age Group	Adults : mean age at recruitment: 55.4 years, SD 15.5; mean age at onset of illness: 38.5 years, SD 15.3 for patients;43.1 years ,SD 14.9 for controls

Detail Info

Sample Diagnosis	DSM
Sample Status	The clinical sample consisted of 534 unrelated Caucasoid patients of Spanish origin with MD (335 MDD and 199 BD) and 440 unrelated controls. Patients were consecutively recruited from two tertiary centers in Barcelona, Bellvitge University Hospital (HUB, n=445) and Hospital de la Santa Creu i Sant Pau (HSP, n=89) between 2004 and 2007.The control group consisted of 440 unrelated participants randomly selected from population registers, who were interviewed at Primary-care Centers in the same geographical area as the referral hospitals.
Technique	genotyping
Statistical Method	Allelic case-control association analysis was performed using X²-tests as implemented in Haploview software v 4.1. Multivariate methods based on logistic regression analyses were used to perform the genotype association analyses.
Result Summary	An excess of transmissions and non transmissions was observed for the DRD4 4- and 2-repeat alleles respectively. The biased transmission showed a parent of origin effect (POE) since it was derived almost exclusively from the maternal meiosis (4-repeat allele maternally transmitted 40 times vs 20 times non-transmitted; chi(2) = 6.667; df = 1; P = 0.009; while paternally transmitted 26 times vs 21 times non-transmitted; chi(2) = 0.531; df = 1; P = 0.46). The analysis of TH did not reveal biased transmission of intron I VNTR alleles. Although replication of our study is necessary, the fact that DRD4 exhibit POE and is located on 11p15.5, in close proximity to a cluster of imprinted genes, suggests that genomic imprinting may be operating in bipolar disorder.

Genetic factors reported by this study for BD

SNPs reported by this study for BD (count: 53)

SNP	Related Gene(s)	Statistical Values	Author Comments	Result Category
rs11121029	PER3	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs11048995	ARNTL2	X²-tests: allele P-value = 0.042	Significant association was found in BD. Significant association was found in BD.	Positive
rs11133379	CLOCK TMEM165	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs11123857	NPAS2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs11610949	ARNTL2	X²-tests: allele P-value = 0.032, Model Log-additive, genotype P-value = 0.015, OR(95%CI)=0.59 (0.38-0.92)	Significant association was found in BD. Significant association was found in BD.	Positive
rs11541353	NPAS2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs12670064	VIPR2	X²-tests: allele P-value = 0.007, Model Log-additive, genotype P-value = 0.006, OR(95%CI)=0.63 (0.46-0.88)	Significant association was found in BD. Significant association was found in BD.	Positive
rs12504300	CLOCK	X²-tests: allele P-value = 0.323, Model Recessive, genotype P-value = 0.03, OR(95%CI)=2.01 (1.08-3.74)	Significant association was found in BD. Significant association was found in BD.	Positive
rs13394520	NPAS2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs13025524	NPAS2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs17025005	NPAS2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1610037	ADCYAP1	X²-tests: allele P-value = 0.044, Model Recessive, genotype P-value = 0.019, OR(95%CI)=1.83 (1.11-3.01)	Significant association was found in BD. Significant association was found in BD.	Positive
rs17452383	BTBD10 ARNTL	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs17083008	VIP	X²-tests: allele P-value = 0.062, Model Recessive, genotype P-value = 0.004, OR(95%CI)=2.68 (1.37-5.22)	Significant association was found in BD. Significant association was found in BD.	Positive
rs17662394	NPAS2	X²-tests: allele P-value = 0.006, Model Log-additive, genotype P-value = 0.007, OR(95%CI)=1.60 (1.14-2.26)	Significant association was found in BD. Significant association was found in BD.	Positive
rs17500692	ADCYAP1	X²-tests: allele P-value = 0.038	Significant association was found in BD. Significant association was found in BD.	Positive
rs10462028	CLOCK TMEM165	X²-tests: allele P-value = 0.329, Model Codominant, genotype P-value = 0.002, OR(95%CI)=0.55 (0.38-0.80)	Significant association was found in BD. Significant association was found in BD.	Positive
rs10506018	ARNTL2	X²-tests: allele P-value = 0.38, Model Recessive, genotype P-value = 0.015, OR(95%CI)=3.43 (1.27-9.31)	Significant association was found in BD. Significant association was found in BD.	Positive
rs10842905	ARNTL2 STK38L	X²-tests: allele P-value = 0.044, Model Log-additive, genotype P-value = 0.046, OR(95%CI)=0.76 (0.58-1.00)	Significant association was found in BD. Significant association was found in BD.	Positive
rs11022778	ARNTL	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs11048994	ARNTL2	X²-tests: allele P-value = 0.377, Model Codominant, genotype P-value = 0.029, OR(95%CI)=0.67 (0.46-0.98)	Significant association was found in BD. Significant association was found in BD.	Positive
rs4640029	MTERFD3 CRY1	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs386551	SPHK2 CA11 DBP SEC1P	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs3793227	VIPR2	X²-tests: allele P-value = 0.047, Model Log-additive, genotype P-value = 0.039, OR(95%CI)=0.66 (0.45-0.99)	Significant association was found in BD. Significant association was found in BD.	Positive
rs3789327	ARNTL	X²-tests: allele P-value = 0.023, Model Recessive, genotype P-value = 0.013, OR(95%CI)=0.60 (0.39-0.90)	Significant association was found in BD. Significant association was found in BD.	Positive
rs4964060	ARNTL2	X²-tests: allele P-value = 0.017, Model Log-additive, genotype P-value = 0.026, OR(95%CI)=1.31 (1.03-1.67)	Significant association was found in BD. Significant association was found in BD.	Positive
rs4963954	BHLHE41	X²-tests: allele P-value = 0.035, Model Dominant, genotype P-value = 0.019, OR(95%CI)=0.66 (0.47-0.93)	Significant association was found in BD. Significant association was found in BD.	Positive
rs4851392	NPAS2	X²-tests: allele P-value = 0.024, Model Dominant, genotype P-value = 0.019, OR(95%CI)=0.65 (0.46-0.94)	Significant association was found in BD. Significant association was found in BD.	Positive
rs4774370	RORA	X²-tests: allele P-value = 0.95, Model Recessive, genotype P-value = 0.031, OR(95%CI)=2.26 (1.09-4.67)	Significant association was found in BD. Significant association was found in BD.	Positive
rs7581886	NPAS2	X²-tests: allele P-value = 0.046, Model Dominant, genotype P-value = 0.038, OR(95%CI)=0.59 (0.35-0.99)	Significant association was found in BD. Significant association was found in BD.	Positive
rs714359	MTERFD3 CRY1	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs688136	VIP	X²-tests: allele P-value = 0.627, Model Codominant, genotype P-value = 0.048, OR(95%CI)=0.73 (0.50-1.07)	Significant association was found in BD. Significant association was found in BD.	Positive
rs6850524	CLOCK	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs969486	ARNTL	X²-tests: allele P-value = 0.022, Model Log-additive, genotype P-value = 0.015, OR(95%CI)=0.69 (0.51-0.93)	Significant association was found in BD. Significant association was found in BD.	Positive
rs969485	ARNTL	X²-tests: allele P-value = 0.015, Model Log-additive, genotype P-value = 0.01, OR(95%CI)=0.68 (0.50-0.91)	Significant association was found in BD. Significant association was found in BD.	Positive
rs900144	ARNTL	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs885861	VIPR2 LINC00689	X²-tests: allele P-value = 0.262, Model Recessive, genotype P-value = 0.034, OR(95%CI)=1.61 (1.04-2.49)	Significant association was found in BD. Significant association was found in BD.	Positive
rs1997644	CSNK1E	X²-tests: allele P-value = 0.396, Model Dominant, genotype P-value = 0.043, OR(95%CI)=1.53 (1.01-2.34)	Significant association was found in BD. Significant association was found in BD.	Positive
rs2070062	CLOCK	X²-tests: allele P-value = 0.987, Model Codominant, genotype P-value = 0.005, OR(95%CI)=0.60 (0.41-0.88)	Significant association was found in BD. Significant association was found in BD.	Positive
rs1801260	CLOCK TMEM165	X²-tests: allele P-value = 0.97, Model Codominant, genotype P-value = 0.004, OR(95%CI)=0.61 (0.42-0.90)	Significant association was found in BD. Significant association was found in BD.	Positive
rs1982350	ARNTL	X²-tests: allele P-value = 0.354, Model Recessive, genotype P-value = 0.05, OR(95%CI)=1.76 (1.01-3.07)	Significant association was found in BD. Significant association was found in BD.	Positive
rs2278749	ARNTL	X²-tests: allele P-value = 0.096, Model Log-additive, genotype P-value = 0.044, OR(95%CI)=1.41 (1.01-1.98)	Significant association was found in BD. Significant association was found in BD.	Positive
rs2279287	ARNTL	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2071427	NR1D1 THRA	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2117713	NPAS2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2304673	PER2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2540352	VIPR2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs228642	PER3	X²-tests: allele P-value = 0.202, Model Recessive, genotype P-value = 0.028, OR(95%CI)=1.66 (1.06-2.60)	Significant association was found in BD. Significant association was found in BD.	Positive
rs2287161	CRY1 MTERFD3	X²-tests: allele P-value = 0.036, Model Log-additive, genotype P-value = 0.043, OR(95%CI)=0.78 (0.62-0.99)	Significant association was found in BD. Significant association was found in BD.	Positive
rs3751222	ARNTL2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs3754674	NPAS2	X²-tests: allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2970844	ARNTL2	X²-tests: allele P-value = 0.012, Model Log-additive, genotype P-value = 0.012, OR(95%CI)=0.62 (0.42-0.91)	Significant association was found in BD. Significant association was found in BD.	Positive
rs35878285	ARNTL2	X²-tests: allele P-value = 0.039, Model Codominant, genotype P-value = 0.033, OR(95%CI)=5.53 (1.04-29.49)	Significant association was found in BD. Significant association was found in BD.	Positive

Genes reported by this study for BD (count: 15)

Gene	Statistical Values/Author Comments	Result Category
VIP	Significant associations of VIP gene were found in BPD patients. Significant associations of VIP gene were found in BPD patients.	Positive
CRY1	Significant associations of CRY1 gene were found in BPD patients. Significant associations of CRY1 gene were found in BPD patients.	Positive
VIPR2	Significant associations of VIPR2 gene were found in BPD patients. Significant associations of VIPR2 gene were found in BPD patients.	Positive
NPAS2	Significant associations of NPAS2 gene were found in BPD patients. Significant associations of NPAS2 gene were found in BPD patients.	Positive
PER3	Significant associations of PER3 gene were found in BPD patients. Significant associations of PER3 gene were found in BPD patients.	Positive
RORA	Significant associations of RORA gene were found in BPD patients. Significant associations of RORA gene were found in BPD patients.	Positive
BHLHE41	Significant associations of BHLHE41 gene were found in BPD patients. Significant associations of BHLHE41 gene were found in BPD patients.	Positive
CLOCK	Significant associations of CLOCK gene were found in BPD patients. Significant associations of CLOCK gene were found in BPD patients.	Positive
NR1D1	No significant associations of NR1D1 gene were found in BPD patients. No significant associations of NR1D1 gene were found in BPD patients.	Negative
PER2	No significant associations of PER2 gene were found in BPD patients. No significant associations of PER2 gene were found in BPD patients.	Negative
ARNTL2	Significant associations of ARNTL2 gene were found in BPD patients. Significant associations of ARNTL2 gene were found in BPD patients.	Positive
CSNK1E	Significant associations of CSNK1E gene were found in BPD patients. Significant associations of CSNK1E gene were found in BPD patients.	Positive
ARNTL	Significant associations of ARNTL gene were found in BPD patients. Significant associations of ARNTL gene were found in BPD patients.	Positive
DBP	No significant associations of DBP gene were found in BPD patients. No significant associations of DBP gene were found in BPD patients.	Negative
ADCYAP1	Significant associations of ADCYAP1 gene were found in BPD patients. Significant associations of ADCYAP1 gene were found in BPD patients.	Positive

Genetic factors reported by this study for SZ and/or MDD

SNPs reported by this study for SZ/MDD

Disease	SNP	Related Gene(s)	Statistical Values	Description	Result Category
MDD	rs13394520	NPAS2	X²-tests:allele P-value = 0.23, Model Recessive, genotype P-value = 0.036, OR(95%CI)=1.59 (1.03-2.44)	Significant association was found.	Positive
MDD	rs1610037	ADCYAP1	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs17025005	NPAS2	X²-tests:allele P-value = 0.092, Model Dominant, genotype P-value = 0.039, OR(95%CI)=0.72 (0.53-0.98)	Significant association was found.	Positive
MDD	rs17083008	VIP	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs17452383	BTBD10 ARNTL	X²-tests:allele P-value = 0.938, Model Recessive, genotype P-value = 0.035, OR(95%CI)=3.00 (1.03-8.77)	Significant association was found.	Positive
MDD	rs17500692	ADCYAP1	X²-tests:allele P-value = 0.038, Model Dominant, genotype P-value = 0.021, OR(95%CI)=0.67 (0.47-0.94)	Significant association was found.	Positive
MDD	rs17662394	NPAS2	X²-tests:allele P-value = 0.014, Model Log-additive, genotype P-value = 0.022, OR(95%CI)=1.43 (1.05-1.95)	Significant association was found.	Positive
MDD	rs1801260	CLOCK TMEM165	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs11121029	PER3	X²-tests:allele P-value = 0.769, Model Recessive, genotype P-value = 0.047, OR(95%CI)=0.43 (0.18-1.04)	Significant association was found.	Positive
MDD	rs11123857	NPAS2	X²-tests:allele P-value = 2E-04, Model Log-additive, genotype P-value = 7.4E-04, OR(95%CI)=1.51 (1.19-1.92)	Significant association was found.	Positive
MDD	rs11133379	CLOCK TMEM165	X²-tests:allele P-value = 0.167, Model Recessive, genotype P-value = 0.046, OR(95%CI)=1.53 (1.01-2.32)	Significant association was found.	Positive
MDD	rs11541353	NPAS2	X²-tests:allele P-value = 0.009, Model Log-additive, genotype P-value = 0.028, OR(95%CI)=1.35 (1.03-1.76)	Significant association was found.	Positive
MDD	rs11610949	ARNTL2	X²-tests:allele P-value = 0.043, Model Log-additive, genotype P-value = 0.018, OR(95%CI)=0.65 (0.46-0.94)	Significant association was found.	Positive
MDD	rs12504300	CLOCK	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs12670064	VIPR2	X²-tests:allele P-value = 0.157, Model Dominant, genotype P-value = 0.044, OR(95%CI)=0.73 (0.53-0.99)	Significant association was found.	Positive
MDD	rs13025524	NPAS2	X²-tests:allele P-value = 0.017, Model Recessive, genotype P-value = 0.004, OR(95%CI)=0.52 (0.33-0.83)	Significant association was found.	Positive
MDD	rs10506018	ARNTL2	X²-tests:allele P-value = 0.098, Model Codominant, genotype P-value = 0.009, OR(95%CI)=0.63 (0.44-0.88)	Significant association was found.	Positive
MDD	rs10462028	CLOCK TMEM165	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs11022778	ARNTL	X²-tests:allele P-value = 0.125, Model Recessive, genotype P-value = 0.022, OR(95%CI)=1.67 (1.08-2.58)	Significant association was found.	Positive
MDD	rs10842905	ARNTL2 STK38L	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs11048995	ARNTL2	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs11048994	ARNTL2	X²-tests:allele P-value = 0.156, Model Codominant, genotype P-value = 0.014, OR(95%CI)=0.65 (0.47-0.90)	Significant association was found.	Positive
MDD	rs969486	ARNTL	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs900144	ARNTL	X²-tests:allele P-value = 0.181, Model Dominant, genotype P-value = 0.023, OR(95%CI)=0.69 (0.50-0.95)	Significant association was found.	Positive
MDD	rs969485	ARNTL	X²-tests:allele P-value = 0.713, Model Codominant, genotype P-value = 0.041, OR(95%CI)=0.75 (0.55-1.02)	Significant association was found.	Positive
MDD	rs7581886	NPAS2	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs885861	VIPR2 LINC00689	X²-tests:allele P-value = 0.009, Model Recessive, genotype P-value = 0.004, OR(95%CI)=1.71 (1.18-2.46)	Significant association was found.	Positive
MDD	rs688136	VIP	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs714359	MTERFD3 CRY1	X²-tests:allele P-value = 0.032, Model Dominant, genotype P-value = 0.022, OR(95%CI)=0.70 (0.51-0.95)	Significant association was found.	Positive
MDD	rs4964060	ARNTL2	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs6850524	CLOCK	X²-tests:allele P-value = 0.056, Model Log-additive, genotype P-value = 0.015, OR(95%CI)=1.30 (1.05-1.61)	Significant association was found.	Positive
MDD	rs4851392	NPAS2	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs4963954	BHLHE41	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs4640029	MTERFD3 CRY1	X²-tests:allele P-value = 0.295, Model Dominant, genotype P-value = 0.048, OR(95%CI)=1.40 (1.00-1.95)	Significant association was found.	Positive
MDD	rs4774370	RORA	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs3793227	VIPR2	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs386551	SPHK2 CA11 DBP SEC1P	X²-tests:allele P-value = 0.104, Model Recessive, genotype P-value = 0.011, OR(95%CI)=2.15 (1.18-3.93)	Significant association was found.	Positive
MDD	rs3789327	ARNTL	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs3754674	NPAS2	X²-tests:allele P-value = 0.097, Model Recessive, genotype P-value = 0.016, OR(95%CI)=0.62 (0.41-0.92)	Significant association was found.	Positive
MDD	rs3751222	ARNTL2	X²-tests:allele P-value = 0.055, Model Codominant, genotype P-value = 0.011, OR(95%CI)=0.54 (0.33-0.87)	Significant association was found.	Positive
MDD	rs35878285	ARNTL2	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs2970844	ARNTL2	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs2540352	VIPR2	X²-tests:allele P-value = 0.035, Model Dominant, genotype P-value = 0.023, OR(95%CI)=0.67 (0.48-0.95)	Significant association was found.	Positive
MDD	rs2304673	PER2	X²-tests:allele P-value = 0.076, Model Dominant, genotype P-value = 0.049, OR(95%CI)=1.39 (1.00-1.94)	Significant association was found.	Positive
MDD	rs2287161	CRY1 MTERFD3	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs228642	PER3	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs2279287	ARNTL	X²-tests:allele P-value = 0.178, Model Dominant, genotype P-value = 0.022, OR(95%CI)=0.71 (0.53-0.95)	Significant association was found.	Positive
MDD	rs2278749	ARNTL	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs2117713	NPAS2	X²-tests:allele P-value = 0.01, Model Log-additive, genotype P-value = 0.006, OR(95%CI)=1.51 (1.13-2.01)	Significant association was found.	Positive
MDD	rs2071427	NR1D1 THRA	X²-tests:allele P-value = 0.235, Model Recessive, genotype P-value = 0.039, OR(95%CI)=1.80 (1.03-3.16)	Significant association was found.	Positive
MDD	rs2070062	CLOCK	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs1997644	CSNK1E	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative
MDD	rs1982350	ARNTL	X²-tests:allele P-value > 0.05, genotype P-value > 0.05 in all model	No significant association was observed.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	CRY1	Significant associations of CRY1 gene were found in MDD patients.	Positive
MDD	NPAS2	Significant associations of NPAS2 gene were found in MDD patients.	Positive
MDD	ARNTL2	Significant associations of ARNTL2 gene were found in MDD patients.	Positive
MDD	ARNTL	Significant associations of ARNTL gene were found in MDD patients.	Positive
MDD	BHLHE41	No significant associations of BHLHE41 gene were found in MDD patients.	Negative
MDD	CLOCK	Significant associations of CLOCK gene were found in MDD patients.	Positive
MDD	CSNK1E	No significant associations of CSNK1E gene were found in MDD patients.	Negative
MDD	PER2	No significant associations of PER2 gene were found in MDD patients.	Positive
MDD	RORA	No significant associations of RORA gene were found in MDD patients.	Negative
MDD	ADCYAP1	Significant associations of ADCYAP1 gene were found in MDD patients.	Positive
MDD	DBP	Significant associations of DBP gene were found in MDD patients.	Positive
MDD	PER3	Significant associations of PER3 gene were found in MDD patients.	Positive
MDD	NR1D1	No significant associations of NR1D1 gene were found in MDD patients.	Positive
MDD	VIP	No significant associations of VIP gene were found in MDD patients.	Negative
MDD	VIPR2	Significant associations of VIPR2 gene were found in MDD patients.	Positive