BDgene

Study Report

Basic Info
Reference
Citation Lerer, B., F. Macciardi, et al. (2001). "Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder." Mol Psychiatry 6(5): 579-585.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 513 patients with recurrent major depression (MDD-R),649 patients with bipolar (BP) affective disorder and 901 normal controls.
SNP/Region/Marker Size 1 variant
Predominant Ethnicity Caucasian
Population European
Gender Male/female:279/370 for BPD patients,163/350 for MDD patients and 426/475 for controls

Detail Info

Genetic factors reported by this study for BD
Other variants reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
MDD HTR2C Cys23Ser HTR2C point mutation Association analysis:Logistic regression, chi square= 7.34, df 1, P-value = 0.006 Significant associations were found in MDD patients. Positive

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD HTR2C In conclusion, we have found that both major depression and bipolar disorder are associated with HT2CR ser23 allele carrier status and that this effect is demonstrable over and above considerable inter-population variability in the frequency of this allele. Positive