Study Report

Reference	Oliveira, J. R.,2000 PMID: 10889543
Citation	Oliveira, J. R., D. R. Carvalho, et al. (2000). "Analysis of the serotonin transporter polymorphism (5-HTTLPR) in Brazilian patients affected by dysthymia, major depression and bipolar disorder." Mol Psychiatry 5(4): 348-349.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	64 patients with bipolar disorder ,66 patients with major depression and 197 control subjects
SNP/Region/Marker Size	1 variant
Predominant Ethnicity
Population	Brazilian
Age Group	Adults : Mean age(SD)(year):41.8(12.5) for BPAD patients,41.3(11.4) for MDD patients and 38.5(9.8) for control subjects

Sample Diagnosis	DSM
Sample Status	A total of 192 patients were included in the present case-control study: 62 with dysthymia, 64 with bipolar disorder and 66 with major depression. The patients with dysthymia,bipolar disorder and major depression were selected from the Institute of Psychiatry (Universidade de Sa?o Paulo) and the Affective Disorder Unity of the Clinical Hospital (Universidade Federal de Pernambuco). All the patients were diagnosed according to the DSM-IV (APA) and/or CID-10 criteria. Among the patients,about 40% were African/Brazilian, and the remaining 60% were Caucasoids. Normal controls included 152 volunteers who worked at the Sa?o Paulo University (or were normal relatives of muscular dystrophy patients without any history of major psychiatric illness) and 45 from the Federal University of Pernambuco with no familial or personal history of psychiatric disorder or treatment, suicide attempt and drug addiction. About 50% of the controls were Caucasoids and the remaining were African/Brazilians.
Technique	PCR and RFLP
Statistical Method	Genotype and gene frequencies were compared among the different groups using chi-squared analysis on contingency tables with allowance for heterogeneity testing and for the analysis of adjusted residuals.
Result Summary	Our data suggest that this functional transporter polymorphism does not seem to play a major role in the genetics of bipolar disorder and major depression in Brazilian patients.