Study Report

Basic Info

Reference	Manki, H.,1996 PMID: 8882909
Citation	Manki, H., S. Kanba, et al. (1996). "Dopamine D2, D3 and D4 receptor and transporter gene polymorphisms and mood disorders." J Affect Disord 40(1-2): 7-13.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	52 bipolar patients,49 unipolar patients and 100 controls
SNP/Region/Marker Size	4 variants
Predominant Ethnicity	Mongloid
Population	Japanese
Gender	25 males and 27 females in BD patients,18 males and 31 females in unipolar patients and 50 males and 50 females in controls
Age Group	Adults : Mean age(SD)(year):46.1(14.6) for BD patients;52.9(15.1) in unipolar patients and 41.1(11.2) for controls

Detail Info

Sample Diagnosis	DSM
Sample Status	The controls were mainly hospital employees and their acquaintances. The patients and the controls were unrelated Japanese subjects residing in the same geographical area.
Technique	Genotyping
Statistical Method	Chi-square tests
Result Summary	Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. Further investigations are needed to clarify the clinical significance of this association in the pathophysiology of mood disorders.

Genetic factors reported by this study for BD

Other variants reported by this study for BD (count: 4)

Variant Name	Related Gene	Type	Allele Change	Statistical Values	Author Comments	Result Category
DAT 40bp repeat	SLC6A3	duplication	multi-alleles	chi square tests:all P-value >0.05	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
DRD3 Ser9Gly	DRD3	point mutation	Ser9Gly	chi square tests:all P-value >0.05	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
DRD4 exon3 VNTR	DRD4	VNTR	multi-alleles	chi square tests:all P-value >0.05	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative
DRD2 S311C	DRD2	point mutation	S311C	chi square tests:all P-value >0.05	No significant differences were found in bipolar groups. No significant differences were found in bipolar groups.	Negative

Genes reported by this study for BD (count: 4)

Gene	Statistical Values/Author Comments	Result Category
DRD3	Our results suggest that there is a significant association between the dopamine D4 receptor gene an...... Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. More...	Negative
DRD2	Our results suggest that there is a significant association between the dopamine D4 receptor gene an...... Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. More...	Negative
DRD4	Our results suggest that there is a significant association between the dopamine D4 receptor gene an...... Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. More...	Negative
SLC6A3	Our results suggest that there is a significant association between the dopamine D4 receptor gene an...... Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

Other variants reported by this study for SZ/MDD

Disease	Variant Name	Related Gene	Type	Statistical Values	Description	Result Category
MDD	DAT 40bp repeat	SLC6A3	duplication	chi square tests:all P-value >0.05	No significant differences were found in unipolar groups.	Negative
MDD	DRD4 exon3 VNTR	DRD4	VNTR	chi square tests:chi square = 6.49, df = 1, P = 0.011 for allele 4; chi square = 5.54, df = 1. P = 0.019 for allele 5.	There was a significant difference between patients with unipolar disorder and controls.	Positive
MDD	DRD3 Ser9Gly	DRD3	point mutation	chi square tests:all P-value >0.05	No significant differences were found in unipolar groups.	Negative
MDD	DRD2 S311C	DRD2	point mutation	chi square tests:all P-value >0.05	No significant differences were found in unipolar groups.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	DRD3	Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders.	Negative
MDD	DRD2	Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders.	Negative
MDD	SLC6A3	Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders.	Negative
MDD	DRD4	Our results suggest that there is a significant association between the dopamine D4 receptor gene and mood disorders, especially major depression, but no association between the other polymorphisms and mood disorders.	Positive