Study Report

Basic Info
Reference |
Mann, J. J., 2008 PMID: 17604842
|
Citation |
Mann, J. J., D. Currier, et al. (2008). "No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover." J Affect Disord 106(1-2): 117-121.
|
Disease Type |
Bipolar Disorder & Major Depressive Disorder |
Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
109 BD, 324 MDD and 130 controls |
SNP/Region/Marker Size |
1 SNP |
Predominant Ethnicity |
Caucasian and Mongloid |

Detail Info
Sample Diagnosis |
DSM-IV |
Technique |
PCR; high-performance liquid chromatography (HPLC) with electrochemical detection |
Statistical Method |
Genotype and allelic distributions were compared groups using the Chi2 contingency table test. One-way analysis of variance was used to compare psychopathology rating scales, and CSF 5-HIAA, HVA, and MHPG levels by genotype. General linear models (GLMs) and logistic regression were used in exploratory analyses. |
Result Summary |
There was no association between genotype and either mood disorder, suicide attempt status, psychopathology severity or CSF monoamine metabolite levels. |

Genetic factors reported by this study for BD

Genetic factors reported by this study for SZ and/or MDD