BDgene

Study Report

Basic Info
Reference
Citation Mann, J. J., D. Currier, et al. (2008). "No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover." J Affect Disord 106(1-2): 117-121.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size 109 BD, 324 MDD and 130 controls
SNP/Region/Marker Size 1 SNP
Predominant Ethnicity Caucasian and Mongloid

Detail Info

Genetic factors reported by this study for BD
SNPs reported by this study for BD (count: 1)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
SNPs reported by this study for SZ/MDD
Disease SNP Related Gene(s) Statistical Values Description Result Category
MDD rs4131347 TBC1D15 TPH2 Genotypic P-value = 0.684, allelic P-value = 0.502 for MDD when compared with controls. There were no differences between MDD and healthy volunteers in genotype or allelic frequency. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD TPH2 No association was detected between the rs4131347 (?C8347G) SNP in the promoter region of the TPH2 gene and mood disorders Negative