Variant Name 
Related Gene 
No. of Studies (Positive/Trend/Negative) for BD 
No. of Studies for MDD 
Overlap with MDD 
Statistical Results 
Description 
Result Category 
Reference 

5HTTLPR 
SLC6A4 
41(12/0/29)

12

twotailed Pvalue=0.649, X^{2}=0.207, df=1 for MDD......
twotailed Pvalue=0.649, X^{2}=0.207, df=1 for MDD patients, Pvalue=0.483, X^{2}=0.491, df=1 for combined patients
More...

the frequency of the 5' regulatory variant alleles did not ......
the frequency of the 5' regulatory variant alleles did not differ between controls and combined patients or MDD patients
More...

Negative

Hoehe, M. R., 1998 
Association analysis:unipolar vs. control, X^{2} =......
Association analysis:unipolar vs. control, X^{2} = 11.760, d.f. = 2, Pvalue = 0.003 for genotypes; Pvalue = 0.001 for alleles.
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Hauser, J.,2003 
Association analysis:allele Pvalue > 0.05, genotype Pvalu......
Association analysis:allele Pvalue > 0.05, genotype Pvalue > 0.05
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Mellerup, E.,2001 
X^{2} (df=1)=2.53, Pvalue = 0.11 for overall. X
X^{2} (df=1)=2.53, Pvalue = 0.11 for overall. X^{2} (df=1)=0.89, Pvalue = 0.35 in the Asian population
More...

The S allele frequency was increased in MDD in most studies......
The S allele frequency was increased in MDD in most studies, but the trend was nonsignificant.
More...

Negative

Lotrich, F. E., 2004 
X^{2} (df=2)=0.62, Pvalue = 0.73 for genotypes; X<......
X^{2} (df=2)=0.62, Pvalue = 0.73 for genotypes; X^{2} (df=1)=0.46, Pvalue = 0.49 for alleles distributions
More...

No significant differences emerged.
No significant differences emerged.

Negative

Mendlewicz, J., 2004 
chi square tests:all Pvalue >0.05
chi square tests:all Pvalue >0.05

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Kunugi, H.,1997(a) 
For MDD, allele, Pvalue = 0.0006;For Mood, allele, Pvalue......
For MDD, allele, Pvalue = 0.0006;For Mood, allele, Pvalue = 0.0068, OR=1.243, Pvalue(perm)=0.304
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Soronen, P.,2011 
Association analysis:chi sauqre test, allele, chi square=1.......
Association analysis:chi sauqre test, allele, chi square=1.143, 1df, Pvalue = 0.29
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Oliveira, J. R.,2000 
metaanalysis:OR=1.05, z=1.07, Pvalue = 0.28, CI (OR): [0.......
metaanalysis:OR=1.05, z=1.07, Pvalue = 0.28, CI (OR): [0.961.14]
More...

No significant associations were found in MDD.
No significant associations were found in MDD.

Negative

LaskySu, J. A.,2005 
frequency of the deleted allele: Pvalue = 0.054, X^{2
frequency of the deleted allele: Pvalue = 0.054, X2=3.72, 1 d.f., frequency in the outpatient sample: Pvalue=0.91, X2=0.01, 1 d.f., the lithium clinic sample: Pvalue=0.010; OR=1.89, CI=1.163.06, X2=6.71, 1 d.f.
More...
} 
Comparing the combined sample of unipolars against controls......
Comparing the combined sample of unipolars against controls there is a reduction in the frequency of the deleted allele that approaches significance. Comparison of the allele frequencies in the two unipolar samples shows that the frequency in the outpatient sample is very close to the control frequency whereas the lithium clinic sample shows a significant decrease in frequency of the deleted allele compared with controls.
More...

Positive

Rees, M., 1997 
Association analysis:chi square test, genotype Pvalue > 0.......
Association analysis:chi square test, genotype Pvalue > 0.05, allele Pvalue > 0.05
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Serretti, A.,2002 
Pvalue>0.05; metaanalysis of Promoter alleles: test of as......
Pvalue>0.05; metaanalysis of Promoter alleles: test of association, Pvalue=0.042, X^{2}=4.1, 1df, OR (95% CI)=1.23 (1.011.52) of 2 vs.1 in the unipolar sample; Pvalue=0.014, X^{2}=6, 1df, OR (95% CI)=1.22 (1.041.42) of 2 vs. 1 in the combined sample; metaanalysis of Promoter genotypes: Test of association, Pvalue=0.076, X^{2}=5.15, 2df, OR (95% CI)=1.55 (1.042.32) of 2 2vs.1 1, OR (95% CI)=1.06 (0.761.49) of 1 2vs.1 1 in the unipolar sample; Pvalue=0.035, X^{2}=6.73, 2df, OR (95% CI)=1.48 (1.021.53) of 2 2vs.1 1, OR (95% CI)=1.10 (0.851.41) of 1 2vs.1 1 in the combined sample.
More...

Allele and genotype frequencies were not significantly diff......
Allele and genotype frequencies were not significantly different from the controls in either of the patient groups or in the combined unipolar and bipolar group. We found a significant association of promoter allele 2 with disease risk in the bipolar , unipolar and the combined bipolar + unipolar groups.
More...

Positive

Furlong, R. A., 1998 (a) 

BDNF Val66Met 
BDNF 
21(11/0/10)

1

Association analysis:genotype Pvalue = 0.598, allele Pval......
Association analysis:genotype Pvalue = 0.598, allele Pvalue = 0.497
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Hong, C. J.,2003 

SLC6A4 intron2 VNTR 
SLC6A4 
16(4/0/12)

6

X^{2} (df=2)=0.14, Pvalue = 0.14 in European/Ameri......
X^{2} (df=2)=0.14, Pvalue = 0.14 in European/American populations. X^{2} (df=2)=2.6, Pvalue = 0.11 in the Asian population
More...

None of the three alleles (Stin2.9, Stin2.10, Stin2.12) wer......
None of the three alleles (Stin2.9, Stin2.10, Stin2.12) were associated with MDD.
More...

Negative

Lotrich, F. E., 2004 
Association analysis:allele Pvalue > 0.05, genotype Pvalu......
Association analysis:allele Pvalue > 0.05, genotype Pvalue > 0.05
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Mellerup, E.,2001 
metaanalysis:OR=0.99, z=0.29, Pvalue = 0.77, CI (OR): [0.......
metaanalysis:OR=0.99, z=0.29, Pvalue = 0.77, CI (OR): [0.921.06]
More...

No significant associations were found in MDD.
No significant associations were found in MDD.

Negative

LaskySu, J. A.,2005 
For the risk of unipolar disorder given a single STin2.9 al......
For the risk of unipolar disorder given a single STin2.9 allele, the odds ratio was 4.44 (95% Cl, 1.6511.95),Pvalue < 0.05
More...

There was a significant difference between patients with un......
There was a significant difference between patients with unipolar disorder and controls in the proportion of individuals carrying the STin2.9 allele.
More...

Positive

Battersby, S.,1996 
chi square tests:all Pvalue >0.05
chi square tests:all Pvalue >0.05

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Kunugi, H.,1997(a) 
For MDD, allele, Pvalue = 0.0017;For Mood, allele, Pvalue......
For MDD, allele, Pvalue = 0.0017;For Mood, allele, Pvalue = 0.0067, OR=1.248, Pvalue(perm)=0.282
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Soronen, P.,2011 

COMT Val158Met 
COMT 
14(2/0/12)

2

Chisquare tests:genotype frequency,chi square = 1.2, df = ......
Chisquare tests:genotype frequency,chi square = 1.2, df = 2, p > 0.05;allele frequencies,chi square = 1.2, df = 1, p > 0.05.
More...

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Kunugi, H.,1997(b) 
Logistic regression analyses, for MDD compared to controls,......
Logistic regression analyses, for MDD compared to controls, genotype:X^{2}wald=4.39, df=2, Pvalue = 0.11;allele:X^{2}wald=1.78, df=1, Pvalue = 0.18
More...

No association emerged between MDD cases and control subjec......
No association emerged between MDD cases and control subjects.But an association was found between the highactivity COMT Val allele, particularly the COMT Val/Val genotype and EOMDD.
More...

Negative

Massat, I.,2005 

MTHFR C677T 
MTHFR 
13(5/0/8)

6

T vs. C: Pvalue Qtest=0.19, Fixed effects OR (95% CI)=1.1......
T vs. C: Pvalue Qtest=0.19, Fixed effects OR (95% CI)=1.15 [0.971.36], Random effects OR (95% CI)=1.14 [0.921.41] in all; Pvalue Qtest=0.05, Fixed effects OR (95% CI)=1.02 [0.771.35], Random effects OR (95% CI)=1.04 [0.591.89] in Caucasians; Pvalue Qtest=0.55, Fixed effects OR (95% CI)=1.23 [1.001.52], Random effects OR (95% CI)=1.23 [1.001.52] in East Asians; TT vs. CC: Pvalue Qtest=0.41, Fixed effects OR (95% CI)=1.27 [0.861.84], Random effects OR (95% CI)=1.28 [0.881.86] in all; Pvalue Qtest=0.5, Fixed effects OR (95% CI)=1.04 [0.571.90], Random effects OR (95% CI)=1.05 [0.512.17] in Caucasians; Pvalue Qtest=0.17, Fixed effects OR (95% CI)=1.44 [0.902.31], Random effects OR (95% CI)=1.45 [0.902.33] in East Asians; TT vs. (TC + CC): Pvalue Qtest=0.68, Fixed effects OR (95% CI)=1.17 [0.831.65], Random effects OR (95% CI)=1.17 [0.831.66] in all; Pvalue Qtest=0.97, Fixed effects OR (95% CI)=0.97 [0.541.72], Random effects OR (95% CI)=0.97 [0.541.72] in Caucasians; Pvalue Qtest=0.21, Fixed effects OR (95% CI)=1.30 [0.842.01], Random effects OR (95% CI)=1.31 [0.852.02] in East Asians; (TT + TC) vs. CC: Pvalue Qtest=0.08, Fixed effects OR (95% CI)=1.21 [0.961.53], Random effects OR (95% CI)=1.20 [0.851.70] in all; Pvalue Qtest=0.04, Fixed effects OR (95% CI)=1.05 [0.721.53], Random effects OR (95% CI)=1.12 [0.413.08] in Caucasians; Pvalue Qtest=0.31, Fixed effects OR (95% CI)=1.32 [0.981.77], Random effects OR (95% CI)=1.32 [0.981.77] in East Asians
More...

In depression, the pattern of results in terms of heterogen......
In depression, the pattern of results in terms of heterogeneity and association is similar to that of bipolar disorder, overall and in east Asians. In Caucasians, there was no association between C677T and depression. It seems that the MTHFR C677T polymorphism plays no role in the development of affective disorders.
More...

Positive

Zintzaras, E., 2006 
chisquare Pvalue=0.84, X^{2}=0, OR=1.1 (0.512.31......
chisquare Pvalue=0.84, X^{2}=0, OR=1.1 (0.512.31)
More...

there was no significantly increased frequency of homozygos......
there was no significantly increased frequency of homozygosity for the T677 allele in any of the diagnostic groups, compared to the controls.
More...

Negative

Kunugi, H., 1998 
X^{2} test:for MD, X^{2}=1.09, genotype P......
X^{2} test:for MD, X^{2}=1.09, genotype Pvalue = 0.580
More...

No significant associations were found.
No significant associations were found.

Negative

Reif, A.,2005 
Fixedeffects OR_{TTvCC} = 1.36, 95 percent CI: 1.1......
Fixedeffects OR_{TTvCC} = 1.36, 95 percent CI: 1.11, 1.67; I^{2} = 0 percent. Fixedeffects OR_{CTvCC} = 1.10, 95 percent CI: 0.96, 1.25; I^{2} = 49 percent.
More...

There was an increased risk of depression among persons wit......
There was an increased risk of depression among persons with the homozygote variant TT genotype, with no discernible statistical betweenstudy heterogeneity. We found a smaller magnitude of association for heterozygotes that was of borderline significance and subject to greater betweenstudy heterogeneity.
More...

Positive

Gilbody, S., 2007 
genotypic Pvalue = 0.111, X^{2}=4.406, allelic Pv......
genotypic Pvalue = 0.111, X^{2}=4.406, allelic Pvalue = 0.345, X^{2}=0.893 in females with unipolar; genotypic Pvalue = 0.545, X^{2}=1.216, allelic Pvalue = 0.308, X^{2}=1.038 in males with unipolar; genotypic Pvalue = 0.104, X^{2}=4.519, allelic Pvalue = 0.301, X^{2}=1.069 in all female patients with unipolar; genotypic Pvalue = 0.700, X^{2}=0.715, allelic Pvalue = 0.431, X^{2}=0.619 in all males patients with unipolar. X^{2}==3.119, d.f.=1, P=0.077, OR=1.46, 95% confidence interval=0.962.22 between controls and all psychiatric cases combined in the dominant model.
More...

The difference between control and unipolar depressive pati......
The difference between control and unipolar depressive patients was not significant at the genotype level or the allelic level. When the data were analyzed separately for each gender, only the female group showed improved statistical significance for genotype distribution. When patients from all the three diagnostic group were combined and analyzed against the controls, there was no significant difference in terms of genotype and allele frequencies for males. With the female group, there was improvement in the level of significance for difference in genotype distribution between controls and all patients. In the dominant model, there was marginally significant difference between controls and and all psychiatric cases combined.
More...

Negative

Tan, E. C., 2004 
Chisquare tests:P < 0.006,OR(95%CI) = 2.8 (1.3â€“6.4)
Chisquare tests:P < 0.006,OR(95%CI) = 2.8 (1.3â€“6.4)

There was a significant difference between patients with un......
There was a significant difference between patients with unipolar disorder and controls.
More...

Positive

Arinami, T.,1997 

MAOA promoter VNTR 
MAOA 
9(0/0/9)

2

Meta analysis:for Asian, OR(95%CI)=1.23(1.021.47), Pvalue......
Meta analysis:for Asian, OR(95%CI)=1.23(1.021.47), Pvalue(Q)=0.03, Pvalue(Z)=0.08;for Caucasian, OR(95%CI)=1.12(0.921.36), Pvalue(Q)=0.24, Pvalue(Z)=0.62
More...

Our metaanalysis showed a significant association between ......
Our metaanalysis showed a significant association between uVNTR and MDD for the Asian group.
More...

Positive

Fan, M.,2010 
Chi square tests:allele,chi square = 0, df = 1, p = 0.84
Chi square tests:allele,chi square = 0, df = 1, p = 0.84

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Kunugi, H.,1999(b) 

DRD3 Ser9Gly 
DRD3 
9(2/0/7)

2

chi square tests:all Pvalue >0.05
chi square tests:all Pvalue >0.05

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Manki, H.,1996 
Association analysis:Conditional logistic regression, all P......
Association analysis:Conditional logistic regression, all Pvalue > 0.05
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Massat, I.,2002(b) 

HTR2A C102T 
HTR2A 
8(0/0/8)

1

Association analysis:z test, allele 205bp, Pvalue > 0.05
Association analysis:z test, allele 205bp, Pvalue > 0.05

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Massat, I.,2000 

MAOA (CA)n 
MAOA 
8(5/0/3)

3

Chi square test:chi square = 3.349, 3 df, Pvalue = 0.34
Chi square test:chi square = 3.349, 3 df, Pvalue = 0.34

No significant differences were found when the control alle......
No significant differences were found when the control allele frequencies were compared with those in unipolar groups.
More...

Negative

Furlong, R. A.,1999(a) 
Pvalue=0.924, X^{2}=5.135, 11 d.f.
Pvalue=0.924, X^{2}=5.135, 11 d.f.

There was no overall or specific association between MAO al......
There was no overall or specific association between MAO alleles and either bipolar or unipolar patients for any of the markers before corrections for multiple tests.
More...

Negative

Muramatsu, T., 1997 
Meta analysis:for Caucasian, a2 allele, OR(95%CI)=0.69(0.43......
Meta analysis:for Caucasian, a2 allele, OR(95%CI)=0.69(0.431.10), Pvalue(Q)=0.12, Pvalue(Z)=0.42, a5 allele, OR(95%CI)=1.24(0.781.95), Pvalue(Q)=0.36, Pvalue(Z)=0.53, a6 allele, OR(95%CI)=0.96(0.681.35), Pvalue(Q)=0.8, Pvalue(Z)=0.31;for Asian, a2 allele, OR(95%CI)=0.93(0.621.42), Pvalue(Q)=0.75, Pvalue(Z)=0.95, a5 allele, OR(95%CI)=0.78(0.441.40), Pvalue(Q)=0.41, Pvalue(Z)=0.88, a6 allele, OR(95%CI)=1.26(0.831.92), Pvalue(Q)=0.28, Pvalue(Z)=0.93
More...

No significant association was observed.
No significant association was observed.

Negative

Fan, M.,2010 

DRD4 exon3 VNTR 
DRD4 
8(1/0/7)

3

chi square tests:chi square = 6.49, df = 1, P = 0.011 for a......
chi square tests:chi square = 6.49, df = 1, P = 0.011 for allele 4; chi square = 5.54, df = 1. P = 0.019 for allele 5.
More...

There was a significant difference between patients with un......
There was a significant difference between patients with unipolar disorder and controls.
More...

Positive

Manki, H.,1996 
The pooled analyses:for 2 repeat allele, OR(95%CI)=1.73(1.2......
The pooled analyses:for 2 repeat allele, OR(95%CI)=1.73(1.292.32), Pvalue = 0.003;for 4 repeat allele, OR(95%CI)=0.88(0.721.09), Pvalue = 0.24;for 7 repeat allele, OR(95%CI)=0.70(0.530.94), Pvalue = 0.02;for short allele, OR(95%CI)=1.23(0.891.70), Pvalue = 0.22
More...

Significant association was found in 2 repeat allele and 7 ......
Significant association was found in 2 repeat allele and 7 repeat allele for MDD(P<0.001).
More...

Positive

Lopez Leon, S.,2005 
Association analysis:chi sauqre test, allele DRD4*Short var......
Association analysis:chi sauqre test, allele DRD4*Short variants, chi square=6.38, d.f.=1, Pvalue = 0.012;genotype DRD4*Short/Short, chi square=11.88, df=2, Pvalue = 0.002
More...

Significant associations were found in MDD patients.
Significant associations were found in MDD patients.

Positive

Serretti, A.,2001(b) 

TPH1 A218C 
TPH1 
6(2/0/4)

2

Association analysis:Chi square tests:alleles, X^{2
Association analysis:Chi square tests:alleles, X2= 0.205, Pvalue = 0.65; genotypes X2= 0.55, Pvalue = 0.757
More...
} 
No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Souery, D.,2001 
Association analysis:chi sauqre test, Pvalue > 0.05
Association analysis:chi sauqre test, Pvalue > 0.05

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Serretti, A.,2001(a) 

5HTT intron 2 VNTR 
SLC6A4 
5(1/0/4)

3

Fisherâ€™s exact test, Pvalue>0.999 between controls and M......
Fisherâ€™s exact test, Pvalue>0.999 between controls and MDD patients of allele 9; Pvalue=0.453 between controls and combined patients of allele 9
More...

the frequency of the second intron allele 9 did not differ ......
the frequency of the second intron allele 9 did not differ between controls and combined patients nor between controls and MDD patients
More...

Negative

Hoehe, M. R., 1998 
genotypes bearing the 9 allele in the outpatient, non lith......
genotypes bearing the 9 allele in the outpatient, non lithium unipolars: Pvalue=0.041, Fisherâ€™s exact test, onetail; Pvalue=0.056, Fisherâ€™s exact test, onetail, when compared against the lithium clinic unipolar probands.
More...

The frequency of the rare 9 allele was greater in unipolars......
The frequency of the rare 9 allele was greater in unipolars (0.04) than controls (0.02) although comparing the combined sample of unipolars against controls reveals no statistically significant difference in allele or genotype distributions. However, the frequency was greater in the outpatient, nonlithium unipolars (0.08) and the overrepresentation of genotypes bearing the 9 allele amongst these probands achieves statistical signifiance when compared against the controls and approaches significance when compared against the lithium clinic unipolar probands.
More...

Positive

Rees, M., 1997 
Pvalue>0.05; metaanalysis of VNTR Alleles: test of associ......
Pvalue>0.05; metaanalysis of VNTR Alleles: test of association, Pvalue=0.92, X^{2}=0.16, 2df, OR (95% CI)=1.16 (0.552.50) of allele 9, OR (95% CI)=1.01 (0.831.23)) of allele 10 in the unipolar sample; Pvalue=0.23, X^{2}=2.92, 2df, OR (95% CI)=1.05 (0.561.95) of allele 9, OR (95% CI)=0.90 (0.771.05) of allele 10 in the combined sample.
More...

Allele and genotype frequencies were not significantly diff......
Allele and genotype frequencies were not significantly different from the controls in either of the patient groups or in the combined unipolar and bipolar group. We found no significant allelic association of the VNTR polymorphism with affective disorder.
More...

Negative

Furlong, R. A., 1998 (a) 

TH intron 1 tetranucleotide repeat 
TH 
5(0/0/5)

2

Fisher's exact test:all Pvalue >0.05
Fisher's exact test:all Pvalue >0.05

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Souery, D.,1996(a) 
For unipolar vs. control: alleles, chi squre = 4.33, 4 df, ......
For unipolar vs. control: alleles, chi squre = 4.33, 4 df, Pvalue = 0.36; genotypes, chi squre = 17.69, 14 df, Pvalue = 0.22;For meta analysis:Pvalue>0.05.
More...

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Furlong, R. A.,1999(c) 

DRD2 S311C 
DRD2 
5(0/0/5)

3

Association analysis:chi sauqre test, Pvalue > 0.05
Association analysis:chi sauqre test, Pvalue > 0.05

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Serretti, A.,2000(a) 
chi square tests:all Pvalue >0.05
chi square tests:all Pvalue >0.05

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Manki, H.,1996 
Meta analysis:SC+CC vsSS :OR (95% CI)=2.14(0.805.72), Z=1.......
Meta analysis:SC+CC vsSS :OR (95% CI)=2.14(0.805.72), Z=1.51, Pvalue = 0.13, F Model, heterogeneity Pvalue = 0.98, I^{2}%=0
More...

No significant association was observed.
No significant association was observed.

Negative

Zou, Y. F.,2010 

HTR2A 1438A/G 
HTR2A 
4(1/0/3)

1

Association analysis:Pvalue > 0.05.
Association analysis:Pvalue > 0.05.

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Bonnier, B.,2002 

SERT VNTR 
SLC6A4 
4(2/0/2)

2

chi square tests:allele 12, Pvalue = 0.011
chi square tests:allele 12, Pvalue = 0.011

Significant differences were found in unipolar groups.
Significant differences were found in unipolar groups.

Positive

Liu, W,1999 
chi square test:allele 12, chi 2 p = 0.18
chi square test:allele 12, chi 2 p = 0.18

No significant differences were found in major depression g......
No significant differences were found in major depression groups.
More...

Negative

Collier, D. A.,1996 

ACE insertion/deletion 
ACE 
4(2/0/2)

2

Association analysis:Alleles, X^{2}=1.228, 1 df, P......
Association analysis:Alleles, X^{2}=1.228, 1 df, Pvalue = 0.27;Genotypes, X^{2}= 1.281, 2 df, Pvalue = 0.57
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Furlong, R. A.,2000 
chi square test:BPAD: Pvalue < 0.05 for genotype DD/(ID+II......
chi square test:BPAD: Pvalue < 0.05 for genotype DD/(ID+II);Pvalue < 0.03 for allele
More...

The D allele was significantly more frequent in the patient......
The D allele was significantly more frequent in the patients with major depression than in the controls, and the DD genotype was significantly more frequent in the patients with major depression than in the controls.
More...

Positive

Arinami, T.,1996 

TH TaqI Polymorphism 
TH 
4(2/0/2)

1

Fisher's exact test:genotype, Fi = 9.99; p = 0.002;homozygo......
Fisher's exact test:genotype, Fi = 9.99; p = 0.002;homozygotesheterozygotes distribution,Fi = 6.28; p = 0.01
More...

There was a significant difference between patients with un......
There was a significant difference between patients with unipolar disorder and controls.
More...

Positive

Souery, D.,1996(a) 

MTHFR A1298C 
MTHFR 
4(3/0/1)

1

X^{2} test:for Md, X^{2}=6.65, genotype P......
X^{2} test:for Md, X^{2}=6.65, genotype Pvalue = 0.036
More...

Significant associations were found in MD patients.
Significant associations were found in MD patients.

Positive

Reif, A.,2005 

rs6195 
NR3C1 
3(0/0/3)

1

X^{2} test:allele, Pvalue > 0.05;the Fisher exact ......
X^{2} test:allele, Pvalue > 0.05;the Fisher exact test:genotype, Pvalue > 0.05
More...

No significant association was observed.
No significant association was observed.

Negative

Szczepankiewicz, A.,2011 

HTR2C Cys23Ser 
HTR2C 
3(3/0/0)

1

Association analysis:Logistic regression, chi square= 7.34,......
Association analysis:Logistic regression, chi square= 7.34, df 1, Pvalue = 0.006
More...

Significant associations were found in MDD patients.
Significant associations were found in MDD patients.

Positive

Lerer, B.,2001 

BDNF (GT)n 
BDNF 
3(2/0/1)

1

Allele distribution:in Bonn sample, for MDD, Pvalue = 0.02......
Allele distribution:in Bonn sample, for MDD, Pvalue = 0.028;in Munich sample, for MDD, Pvalue = 0.084
More...

Significant association was found in Bonn sample.
Significant association was found in Bonn sample.

Positive

Schumacher, J.,2005 

TH PstI Polymorphism 
TH 
3(0/0/3)

1

For Cambridge unipolar vs. control: alleles, chi squre = 3.......
For Cambridge unipolar vs. control: alleles, chi squre = 3.946, 1 df, Pvalue = 0.047; genotypes, chi squre = 4.436, 2 df, Pvalue = 0.11; for Edinburgh unipolar vs. control: alleles, chi squre = 0.661, 1df, Pvalue = 0.42; genotypes, chi squre = 2.274, 2 df, Pvalue = 0.32.
More...

Significant differences were found in Cambridge unipolar gr......
Significant differences were found in Cambridge unipolar groups.
More...

Positive

Furlong, R. A.,1999(c) 

WFS1 G576S 
WFS1 
3(0/0/3)

1

Association analysis:chi sauqre test, allele Pvalue = 0.26
Association analysis:chi sauqre test, allele Pvalue = 0.26

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Ohtsuki, T.,2000 

WFS1 H611R 
WFS1 
3(0/0/3)

1

Alleles:chi square = 2.37,1df,Pvalue = 0.12;Genotypes:chi ......
Alleles:chi square = 2.37,1df,Pvalue = 0.12;Genotypes:chi square = 2.40,2df,Pvalue = 0.30
More...

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Furlong, R. A.,1999(b) 

MAOA T941G 
MAOA 
3(2/0/1)

2

Meta analysis:for Asian, OR(95%CI)=0.78(0.531.13), Pvalue......
Meta analysis:for Asian, OR(95%CI)=0.78(0.531.13), Pvalue(Q)=0.19, Pvalue(Z)=0.84;for Caucasian, OR(95%CI)=1.16(0.891.52), Pvalue(Q)=0.27, Pvalue(Z)=0.82
More...

No significant association was observed.
No significant association was observed.

Negative

Fan, M.,2010 
no Pvalue was given
no Pvalue was given

No significant differences in the allele or genotype distri......
No significant differences in the allele or genotype distribution were observed between the control group and any disease group.
More...

Negative

Sasaki, T., 1998 

MAOB (GT)n 
MAOB 
3(1/0/2)

2

Pvalue=0.109, X^{2}=16.954, 11 d.f.
Pvalue=0.109, X^{2}=16.954, 11 d.f.

There was no overall or specific association between MAO al......
There was no overall or specific association between MAO alleles and either bipolar or unipolar patients for any of the markers before corrections for multiple tests.
More...

Negative

Muramatsu, T., 1997 
Association analysis:z test, allele 116bp, Pvalue > 0.05
Association analysis:z test, allele 116bp, Pvalue > 0.05

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Lin, S.,2000 

DDC 1bp del 
DDC 
3(2/0/1)

2

Statistical analysis of the 4bp deletion: all Pvalues > 0......
Statistical analysis of the 4bp deletion: all Pvalues > 0.05.
More...

No significant association was found between the 4bp delet......
No significant association was found between the 4bp deletion and Unipolar patients.
More...

Negative

Borglum, A. D.,1999 
Association analysis:Fisher's exact test, Pvalue > 0.05
Association analysis:Fisher's exact test, Pvalue > 0.05

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Jahnes, E.,2002 

DDC 4bp del 
DDC 
3(1/0/2)

2

Statistical analysis of the 4bp deletion: all Pvalues > 0......
Statistical analysis of the 4bp deletion: all Pvalues > 0.05.
More...

No significant association was found between the 4bp delet......
No significant association was found between the 4bp deletion and Unipolar patients.
More...

Negative

Borglum, A. D.,1999 
Association analysis:Fisher's exact test, Pvalue > 0.05
Association analysis:Fisher's exact test, Pvalue > 0.05

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Jahnes, E.,2002 

GPR50 delta502505 
GPR50 
3(1/0/2)

2

Single marker association:for MDD, allele Pvalue = 0.011(a......
Single marker association:for MDD, allele Pvalue = 0.011(all), Pvalue = 0.48(male), Pvalue = 0.0064(female)
More...

Association was observed in MDD and MDD(female).
Association was observed in MDD and MDD(female).

Positive

Thomson, P. A.,2005(b) 
X^{2} goodness of fit test:Pvalue > 0.05
X^{2} goodness of fit test:Pvalue > 0.05

No significant association was observed.
No significant association was observed.

Negative

Macintyre, D. J.,2010 

ADCY9 2316A>G 
ADCY9 
2(1/0/1)

1

Association analysis:X^{2} test, genotype Pvalue =......
Association analysis:X^{2} test, genotype Pvalue = 0.389, allele Pvalue = 0.287
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Toyota, T.,2002 

ADCY9 (TTTA)n 
ADCY9 
2(1/0/1)

1

Association analysis:X^{2} test, genotype Pvalue =......
Association analysis:X^{2} test, genotype Pvalue = 0.881, allele Pvalue = 0.691
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Toyota, T.,2002 

HTR6 267C/T 
HTR6 
2(1/0/1)

1

Chi square test:genotype Pvalue = 0.372;allele Pvalue = 0......
Chi square test:genotype Pvalue = 0.372;allele Pvalue = 0.628
More...

No significant differences were found in major depression g......
No significant differences were found in major depression groups.
More...

Negative

Hong, C. J.,1999 

COMT H/L 
COMT 
2(1/0/1)

1

X^{2} = 5.72, df = 1, Pvalue = 0.012; OR=2.19, 95%......
X^{2} = 5.72, df = 1, Pvalue = 0.012; OR=2.19, 95%CI=1.194.03, Lod score=0.340
More...

Patients with depressive disorders exhibited a significantl......
Patients with depressive disorders exhibited a significantly higher rate of genotypes with the COMTL allele than healthy controls, which was not the case in patients with bipolar disorders. The presence of the COMTL allele was significantly associated with depressive disorders.
More...

Positive

Ohara, K., 1998 

TPH1 intron 7 218A/C 
TPH1 
2(0/0/2)

1

Chi square tests:genotype,chi square = 2.2, df = 2, p = 0.3......
Chi square tests:genotype,chi square = 2.2, df = 2, p = 0.34;allele,chi square = 0.9, df = 1, p = 0.35
More...

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Kunugi, H.,1999(a) 

DAT 40bp repeat 
SLC6A3 
2(0/0/2)

1

chi square tests:all Pvalue >0.05
chi square tests:all Pvalue >0.05

No significant differences were found in unipolar groups.
No significant differences were found in unipolar groups.

Negative

Manki, H.,1996 

rs1129647 
GABRA1 
1(1/0/0)

1

Association analysis:genotype Pvalue = 0.07, allele Pvalu......
Association analysis:genotype Pvalue = 0.07, allele Pvalue = 0.08
More...

No significant association was observed.
No significant association was observed.

Negative

Horiuchi, Y.,2004 

ABCA13 exon33 H3609P 
ABCA13 
1(0/0/1)

1

Fisher's exact test: Pvalue = 0.130, Odds Ratio=2.62 in MD......
Fisher's exact test: Pvalue = 0.130, Odds Ratio=2.62 in MDD
More...

No significant associations were found in SZ and MDD.
No significant associations were found in SZ and MDD.

Negative

Knight, H. M.,2009 

ABCA13 exon40 T4031A 
ABCA13 
1(1/0/0)

1

Fisher's exact test: Pvalue = 0.130, Odds Ratio=2.62 in MD......
Fisher's exact test: Pvalue = 0.130, Odds Ratio=2.62 in MDD
More...

No significant associations were found in SZ and MDD.
No significant associations were found in SZ and MDD.

Negative

Knight, H. M.,2009 

ABCA13 exon52 R4590W 
ABCA13 
1(0/0/1)

1

Fisher's exact test: Pvalue = 0.130, Odds Ratio=2.62 in MD......
Fisher's exact test: Pvalue = 0.130, Odds Ratio=2.62 in MDD
More...

No significant associations were found in SZ and MDD.
No significant associations were found in SZ and MDD.

Negative

Knight, H. M.,2009 

ABCA13 exon52 T4550A 
ABCA13 
1(1/0/0)

1

Fisher's exact test: Pvalue = 0.63, Odds Ratio=1.18 in MDD......
Fisher's exact test: Pvalue = 0.63, Odds Ratio=1.18 in MDD
More...

No significant associations were found in SZ and MDD.
No significant associations were found in SZ and MDD.

Negative

Knight, H. M.,2009 

ABCA13 exon54 R4728X 
ABCA13 
1(0/0/1)

1

Fisher's exact test: Pvalue = 0.600, Odds Ratio=1.21 in MD......
Fisher's exact test: Pvalue = 0.600, Odds Ratio=1.21 in MDD
More...

No significant associations were found in SZ and MDD.
No significant associations were found in SZ and MDD.

Negative

Knight, H. M.,2009 

ABCA13 exon57 R4843C 
ABCA13 
1(0/0/1)

1

Fisher's exact test: Pvalue = 0.630, Odds Ratio=1.02 in MD......
Fisher's exact test: Pvalue = 0.630, Odds Ratio=1.02 in MDD
More...

No significant associations were found in MDD.
No significant associations were found in MDD.

Negative

Knight, H. M.,2009 

SCYA2 A2518G 
CCL2 
1(1/0/0)

1


No genotypic or allelic association for the A2518G polymor......
No genotypic or allelic association for the A2518G polymorphism of SCYA2 was found considering MDD cases and controls. The present preliminary results may represent a biological discriminative influence between mood disorder subtypes.
More...

Negative

Altamura, A. C., 2010 

HTR4 IVS1+15T/C 
HTR4 
1(0/0/1)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 0.47, allele Pvalue = 0.69, OR=0.4OR(95%CI)=0.13.4
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Ohtsuki, T.,2002 

HTR4 IVS3+63C/T 
HTR4 
1(0/0/1)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 0.8, allele Pvalue = 0.84, OR=0.9OR(95%CI)=0.42.0
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Ohtsuki, T.,2002 

HTR4 IVS3+6G/A 
HTR4 
1(0/0/1)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 1, allele Pvalue = 1, OR=0.97OR(95%CI)=0.52.0
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Ohtsuki, T.,2002 

HTR4 IVS4+36T/C 
HTR4 
1(0/0/1)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 0.49, allele Pvalue = 0.6, OR=1.3OR(95%CI)=0.62.6
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Ohtsuki, T.,2002 

HTR4 SVRSNP1 
HTR4 
1(1/0/0)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 0.001, allele Pvalue = 0.0007, OR=2.1OR(95%CI)=1.43.2
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Ohtsuki, T.,2002 

HTR4 SVRSNP2 
HTR4 
1(1/0/0)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 0.08, allele Pvalue = 0.68, OR=0.2OR(95%CI)=0.52.6
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Ohtsuki, T.,2002 

HTR4 SVRSNP3 
HTR4 
1(1/0/0)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 0.09, allele Pvalue = 0.1, OR=1.7OR(95%CI)=0.93.3
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Ohtsuki, T.,2002 

HTR4 SVRSNP4 
HTR4 
1(1/0/0)

1

Association analysis:Fisher's exact test, genotype Pvalue ......
Association analysis:Fisher's exact test, genotype Pvalue = 0.03, allele Pvalue = 0.15, OR=1.4OR(95%CI)=0.92.3
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Ohtsuki, T.,2002 

HTR5A 12A/T 
HTR5A 
1(0/0/1)

1

Association analysis:X^{2} test:MD vs C: X^{2
Association analysis:X2 test:MD vs C: X2=0.72, Pvalue = 0.86
More...
} 
No significant association was observed.
No significant association was observed.

Negative

Arias, B., 2001 

HTR5A 19G/C 
HTR5A 
1(0/0/1)

1

Association analysis:X^{2} test:MD vs C: X^{2
Association analysis:X2 test:MD vs C: X2=1.05, Pvalue = 0.59
More...
} 
No significant association was observed.
No significant association was observed.

Negative

Arias, B., 2001 

SOD2 Ala9Val 
SOD2 
1(0/0/1)

1

genotypic Pvalue = 0.144, X^{2}=1.561; allelic Pv......
genotypic Pvalue = 0.144, X^{2}=1.561; allelic Pvalue = 0.199, X^{2}=1.650 between MDD patients and controls; genotypic Pvalue = 0.369, X^{2}=1.99, allelic Pvalue = 0.266, X^{2}=1.24 in the combined patient group and controls
More...

The genotype and allele distribution of the Ala9Val MnSOD ......
The genotype and allele distribution of the Ala9Val MnSOD polymorphism was similar in the MDD patients and controls. Moreover, the distribution of genotypes and alleles in the Ala9Val MnSOD polymorphism were similar in the combined patient group (MDD plus BD) and controls.
More...

Negative

Pae, C. U., 2006 

IL10 1082G/A 
IL10 
1(0/0/1)

1

chisquare test:Comparison between MDD and CT: Genotype: X......
chisquare test:Comparison between MDD and CT: Genotype: X^{2}=15.317, df=2, Pvalue < 0.001.
More...

The genotype distribution was significantly different betwe......
The genotype distribution was significantly different between MDD and control (P<0.001)
More...

Positive

Clerici, M.,2009 

TBX1 v14186 
TBX1 
1(0/0/1)

1

X^{2}= 0.080, Pvalue = 0.777 for affective disord......
X^{2}= 0.080, Pvalue = 0.777 for affective disorder (BP + MDD) when compared with controls
More...

None of the nine individual SNPs showed a positive associat......
None of the nine individual SNPs showed a positive association in the 'all affecteds' category.
More...

Negative

Funke, B. H., 2007 

CCK STR 
CCK 
1(0/0/1)

1

Association study:Pvalue (genotypic)=0.323, Pvalue (allel......
Association study:Pvalue (genotypic)=0.323, Pvalue (allelic)=0.296 for unipolar disorder.
More...

No significant association was observed.
No significant association was observed.

Negative

Hattori, E.,2002 

TH 15 allele 
TH 
1(0/0/1)

1

Fisherâ€™s exact test, Pvalue=0.88 for UPR, Pvalue=1 for ......
Fisherâ€™s exact test, Pvalue=0.88 for UPR, Pvalue=1 for BPI + UPR; Fisherâ€™s exact test, Pvalue=0.32 for UPR, Pvalue=0.26 for BPI + UPR; Fisherâ€™s exact test, Pvalue=0.66 for UPR, Pvalue=0.47 for BPI + UPR; Fisherâ€™s exact test, Pvalue=1 for UPR, Pvalue=0.72 for BPI + UPR; Fisherâ€™s exact test, Pvalue=0.54 for UPR, Pvalue=0.8 for BPI + UPR; Fisherâ€™s exact test, Pvalue=0.79 for UPR, Pvalue=0.72 for BPI + UPR; Fisherâ€™s exact test, Pvalue=0.91 for UPR, Pvalue=0.85 for BPI + UPR
More...

For the TH polymorphism, the '1,2' genotype was more freque......
For the TH polymorphism, the '1,2' genotype was more frequently observed among controls than in the patient group. However, this P value does not remain significant after applying a Bonferroni correction for multiple testing. When considering only BPI or UPR patients who were positive for family history, no significant differences were observed, either.
More...

Negative

Oruc, L., 1997 (a) 

KAT5 BanI polymorphism 
KAT5 
1(0/0/1)

1

Association analysis:chi square test, allele Pvalue = 0.00......
Association analysis:chi square test, allele Pvalue = 0.007, chi square=7.072;genotype Pvalue = 0.03, chi square=6.879
More...

Significant associations were found in MDD patients.
Significant associations were found in MDD patients.

Positive

Pae, C. U.,2004(b) 

COMT G/A 
COMT 
1(1/0/0)

1

genotypic Pvalue = 0.32, X^{2}=2.29, d.f.=2 for th......
genotypic Pvalue = 0.32, X^{2}=2.29, d.f.=2 for the Milan sample
More...

COMT variants were not associated with mood disorders in ou......
COMT variants were not associated with mood disorders in our sample.
More...

Negative

Serretti, A., 2006 

CRHR2 1047G/A 
CRHR2 
1(0/0/1)

1

Association analysis:X^{2} test, genotype Pvalue =......
Association analysis:X^{2} test, genotype Pvalue = 0.03, allele Pvalue = 0.04
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Villafuerte, S. M.,2002 

TSPO exon4 Ala147Thr 
TSPO 
1(0/0/1)

1

Association analysis:X^{2} test:genotype Pvalue = ......
Association analysis:X^{2} test:genotype Pvalue = 0.120;allele Pvalue = 0.120
More...

No significant association was observed.
No significant association was observed.

Negative

Kurumaji, A.,2001 

TSPO exon4 His162Arg 
TSPO 
1(0/0/1)

1

Association analysis:X^{2} test:genotype Pvalue = ......
Association analysis:X^{2} test:genotype Pvalue = 0.607;allele Pvalue = 0.854
More...

No significant association was observed.
No significant association was observed.

Negative

Kurumaji, A.,2001 

MAOA A1609G 
MAOA 
1(0/0/1)

1

no Pvalue was given
no Pvalue was given

No G allele was observed in any of the Japanese subjects.
No G allele was observed in any of the Japanese subjects.

Negative

Sasaki, T., 1998 

uMAOA 
MAOA 
1(0/0/1)

1

Genotypic Pvalue = 0.327, allelic Pvalue = 0.808
Genotypic Pvalue = 0.327, allelic Pvalue = 0.808

None of the different repeat copies was found to be associa......
None of the different repeat copies was found to be associated with major depression.
More...

Negative

Gutierrez, B., 2004 

MAOA exon 8 RFLP 
MAOA 
1(0/0/1)

1

Pvalue=0.426, X^{2}=0.634, 1 d.f.
Pvalue=0.426, X^{2}=0.634, 1 d.f.

There was no overall or specific association between MAO al......
There was no overall or specific association between MAO alleles and either bipolar or unipolar patients for any of the markers before corrections for multiple tests.
More...

Negative

Muramatsu, T., 1997 

MAOA exon 8 VNTR 
MAOA 
1(0/0/1)

1

Pvalue=0.143, X^{2}=6.863, 4 d.f.
Pvalue=0.143, X^{2}=6.863, 4 d.f.

There was no overall or specific association between MAO al......
There was no overall or specific association between MAO alleles and either bipolar or unipolar patients for any of the markers before corrections for multiple tests.
More...

Negative

Muramatsu, T., 1997 

MAOAFnu 
MAOA 
1(0/0/1)

1

Chi square test:chi square = 0.821, 1 df, Pvalue = 0.37
Chi square test:chi square = 0.821, 1 df, Pvalue = 0.37

No significant differences were found when the control alle......
No significant differences were found when the control allele frequencies were compared with those in unipolar groups.
More...

Negative

Furlong, R. A.,1999(a) 

COMT G1947A 
COMT 
1(0/0/1)

1

Pvalue=0.794 for Val/Val158, Pvalue=0.471 for Val/Met158,......
Pvalue=0.794 for Val/Val158, Pvalue=0.471 for Val/Met158, Pvalue=0.256 for Met/Met158, allelic Pvalue=0.393
More...

The Val/Met158 genotype was the most represented in all thr......
The Val/Met158 genotype was the most represented in all three groups, with higher frequencies in MDD and BD patients than incontrols, while the Met/Met158 mutated genotype was morefrequent in healthy subjects than inpatients. However, thesedifferences did not reach statistically significant values. The resultsof posthoc power analysis showed that the study was insufficientlypowered to detect the true association of G1947A(Val158Met) variant of COMT gene with MDD and BD, if existent in these populations.
More...

Negative

Pandolfo, G., 2015 

COMT C1886G 
COMT 
1(1/0/0)

1

Pvalue=0.002 for CC1886, Pvalue=0.025 for CG1947, Pvalue......
Pvalue=0.002 for CC1886, Pvalue=0.025 for CG1947, Pvalue=0.216 for GG1947, allelic Pvalue=0.003
More...


Positive

Pandolfo, G., 2015 

MAOA LPR 
MAOA 
1(0/0/1)

1

Association analysis:Chi square tests:alleles, X^{2
Association analysis:Chi square tests:alleles, X2= 0.219, Pvalue = 0.731
More...
} 
No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Syagailo, Y. V.,2001 

WFS1 SNP1023 
WFS1 
1(0/0/1)

1

Allelic association:Pvalue = 0.02 in MDD.
Allelic association:Pvalue = 0.02 in MDD.

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Koido, K.,2005 

WFS1 SNP1185 
WFS1 
1(0/0/1)

1

Allelic association:Pvalue = 0.01 in MDD, Genotypic associ......
Allelic association:Pvalue = 0.01 in MDD, Genotypic association:Pvalue = 0.008 in MDD.
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Koido, K.,2005 

WFS1 SNP1645 
WFS1 
1(0/0/1)

1

Allelic association:Pvalue = 0.55 in MDD.
Allelic association:Pvalue = 0.55 in MDD.

No significant associations were found in MDD.
No significant associations were found in MDD.

Negative

Koido, K.,2005 

WFS1 SNP1832 
WFS1 
1(0/0/1)

1

Allelic association:Pvalue = 0.17 in MDD, Genotypic associ......
Allelic association:Pvalue = 0.17 in MDD, Genotypic association:Pvalue = 0.17 in MDD.
More...

No significant associations were found in MDD.
No significant associations were found in MDD.

Negative

Koido, K.,2005 

WFS1 SNP2206 
WFS1 
1(0/0/1)

1

Allelic association:Pvalue = 0.04 in MDD.
Allelic association:Pvalue = 0.04 in MDD.

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Koido, K.,2005 

WFS1 SNP2565 
WFS1 
1(0/0/1)

1

Allelic association:Pvalue = 0.04 in MDD.
Allelic association:Pvalue = 0.04 in MDD.

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Koido, K.,2005 

WFS1 SNP684 
WFS1 
1(1/0/0)

1

Allelic association:Pvalue = 0.007 in MDD, Genotypic assoc......
Allelic association:Pvalue = 0.007 in MDD, Genotypic association:Pvalue = 0.26 in MDD.
More...

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Koido, K.,2005 

WFS1 SNP935 
WFS1 
1(0/0/1)

1

Allelic association:Pvalue = 0.19 in MDD.
Allelic association:Pvalue = 0.19 in MDD.

No significant associations were found in MDD.
No significant associations were found in MDD.

Negative

Koido, K.,2005 

DISC1 215(TG)813 
DISC1 
1(0/0/1)

1

Genotypic Pvalue = 0.83, allelic Pvalue = 1.00 f
Genotypic Pvalue = 0.83, allelic Pvalue = 1.00 f

no significant differences between unipolar disorder and co......
no significant differences between unipolar disorder and controls
More...

Negative

Arai, M., 2007 

mtDNA ND4L T10652C 
mtDNA_ND4L 
1(1/0/0)

1

Allelic association analysis:Pvalue(permutation)=0.026
Allelic association analysis:Pvalue(permutation)=0.026

Significant associations were found in MDD.
Significant associations were found in MDD.

Positive

Rollins, B.,2009 

NCAM1 2208T>G 
NCAM1 
1(0/0/1)

1

Fisher's exact test genotypic Pvalue = 0.54 , allelic Pva......
Fisher's exact test genotypic Pvalue = 0.54 , allelic Pvalue = 0.92
More...

For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...

Negative

Arai, M., 2004 

NCAM1 2256 2257 insATGG 
NCAM1 
1(0/0/1)

1

Fisher's exact test genotypic Pvalue = 0.14 , allelic Pva......
Fisher's exact test genotypic Pvalue = 0.14 , allelic Pvalue = 0.14
More...

For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...

Negative

Arai, M., 2004 

NCAM1 I621G>T 
NCAM1 
1(0/0/1)

1

Fisher's exact test genotypic Pvalue = 0.28 , allelic Pva......
Fisher's exact test genotypic Pvalue = 0.28 , allelic Pvalue = 0.29
More...

For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...

Negative

Arai, M., 2004 

NCAM1 IVS049de IG 
NCAM1 
1(0/0/1)

1

Fisher's exact test genotypic Pvalue = 0.95 , allelic Pva......
Fisher's exact test genotypic Pvalue = 0.95 , allelic Pvalue = 0.89
More...

For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...

Negative

Arai, M., 2004 

NCAM1 IVS4+80G>C 
NCAM1 
1(0/0/1)

1

Fisher's exact test genotypic Pvalue = 0.85, allelic Pva......
Fisher's exact test genotypic Pvalue = 0.85, allelic Pvalue = 0.72
More...

For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...

Negative

Arai, M., 2004 

NCAM1 IVS6+32T>C 
NCAM1 
1(1/0/0)

1

Fisher's exact test genotypic Pvalue = 0.37 , allelic Pva......
Fisher's exact test genotypic Pvalue = 0.37 , allelic Pvalue = 0.90
More...

For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...

Negative

Arai, M., 2004 

NCAM1 IVS7+155G>T 
NCAM1 
1(0/0/1)

1

Fisher's exact test genotypic Pvalue = 0.89 , allelic Pva......
Fisher's exact test genotypic Pvalue = 0.89 , allelic Pvalue = 0.76
More...

For unipolar disorder, none of these polymorphisms displaye......
For unipolar disorder, none of these polymorphisms displayed nominally significant genotypic or allelic associations with the disease.
More...

Negative

Arai, M., 2004 

DRD2 141CIns/Del 
DRD2 
1(0/0/1)

1

allelic Pvalue=0.82, X^{2}=0.06, df=1; genotypic P......
allelic Pvalue=0.82, X^{2}=0.06, df=1; genotypic Pvalue=0.91, X^{2}=0.01, df=1; OR (95% CI)=1.06 (0.641.75) of allele 2 vs. 1, OR (95% CI)=1.03 (0.581.83) of 2 2 vs. 1 2 in bipolar; allelic Pvalue=0.72, X^{2}=0.13, df=1; genotypic Pvalue=0.31, X^{2}=1.03, df=1; OR (95% CI)=0.93 (0.631.38) of allele 2 vs. 1, OR (95% CI)=0.80 (0.511.24) of 2 2 vs. 1 2 in the combined sample
More...

No significant association with this polymorphism was found......
No significant association with this polymorphism was found in either disorder, not even when both groups were combined to give an 'affective disorder' group.
More...

Negative

Furlong, R. A., 1998 (b) 

DRD2 microsatellite 
DRD2 
1(1/0/0)

1

Association analysis:Conditional logistic regression, all P......
Association analysis:Conditional logistic regression, all Pvalue > 0.05
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Massat, I.,2002(b) 

DRD4 210 allele 
DRD4 
1(0/0/1)

1

2 (218) Allele (bp): Fisherâ€™s exact test, Pvalue=0.18 fo......
2 (218) Allele (bp): Fisherâ€™s exact test, Pvalue=0.18 for UPR, Pvalue=0.34 for BPI + UPR; 3 (266) Allele (bp): Fisherâ€™s exact test, Pvalue=0.49 for UPR, Pvalue=0.56 for BPI + UPR; 4 (314) Allele (bp): Fisherâ€™s exact test, Pvalue=0.19 for UPR, Pvalue=0.39 for BPI + UPR; 5 (362) Allele (bp): Fisherâ€™s exact test, Pvalue=1 for UPR, Pvalue=0.66 for BPI + UPR; 6 (410) Allele (bp): Fisherâ€™s exact test, Pvalue=1 for UPR, Pvalue=1 for BPI + UPR; 7 (458) Allele (bp): Fisherâ€™s exact test, Pvalue=0.71 for UPR, Pvalue=1 for BPI + UPR; 8 (506) Allele (bp): Fisherâ€™s exact test, Pvalue=0.8 for UPR, Pvalue=0.8 for BPI + UPR; 9 (554) Allele (bp): Fisherâ€™s exact test, Pvalue=0.44 for UPR, Pvalue=0.18 for BPI + UPR; 10 (602) Allele (bp): Fisherâ€™s exact test, Pvalue=1 for UPR, Pvalue=1 for BPI + UPR; Total: Fisherâ€™s exact test, Pvalue=0.26 for UPR, Pvalue=0.27 for BPI + UPR; Homozygotes: Fisherâ€™s exact test, Pvalue=0.24 for UPR, Pvalue=0.51 for BPI + UPR
More...

No significant differences were observed at the singlealle......
No significant differences were observed at the singleallele level when comparing the UPR, BPI, or combined patient populations vs. controls.
More...

Negative

Oruc, L., 1997 (a) 

DRD5 D4S615 
DRD5 
1(0/0/1)

1

Association analysis:CLUMP program, Pvalue > 0.05
Association analysis:CLUMP program, Pvalue > 0.05

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Muir, W. J.,2001 

DUSP6 exon1 Leu111Val 
DUSP6 
1(0/0/1)

1

Association analysis:allele frequencies, X^{2} = 0.......
Association analysis:allele frequencies, X^{2} = 0.61, 1 df, Pvalue = 0.43;genotypes, Pvalue = 0.44
More...

No significant association was observed.
No significant association was observed.

Negative

Toyota, T.,2000 

DUSP6 Leu114Val 
DUSP6 
1(0/0/1)

1

Association analysis:chi square test, allele Pvalue = 0.43......
Association analysis:chi square test, allele Pvalue = 0.43;genotype Pvalue = 0.44
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Toyota, T,2000 

NOS3 G894T 
NOS3 
1(0/0/1)

1

genotypic Pvalue = 0.82, X^{2}=0.41, df=2
genotypic Pvalue = 0.82, X^{2}=0.41, df=2

Individual SNP association analyses by means of chi square ......
Individual SNP association analyses by means of chi square tests did not yield significant results. Similarly, no significant association between any of the polymorphisms and BD, and MD respectively, was obtained when comparing allele distributions (data not shown).
More...

Negative

Reif, A., 2006 (b) 

NOS3 Intron4 VNTR 
NOS3 
1(0/0/1)

1

genotypic Pvalue = 0.88, X^{2}=0.66, df=3
genotypic Pvalue = 0.88, X^{2}=0.66, df=3

Individual SNP association analyses by means of chi square ......
Individual SNP association analyses by means of chi square tests did not yield significant results. Similarly, no significant association between any of the polymorphisms and BD, and MD respectively, was obtained when comparing allele distributions (data not shown).
More...

Negative

Reif, A., 2006 (b) 

NOS3 T786C 
NOS3 
1(0/0/1)

1

genotypic Pvalue = 0.51, X^{2}=1.35, df=2
genotypic Pvalue = 0.51, X^{2}=1.35, df=2

Individual SNP association analyses by means of chi square ......
Individual SNP association analyses by means of chi square tests did not yield significant results. Similarly, no significant association between any of the polymorphisms and BD, and MD respectively, was obtained when comparing allele distributions (data not shown).
More...

Negative

Reif, A., 2006 (b) 

NQO1 C609T 
NQO1 
1(0/0/1)

1

chisquare test, genotypic Pvalue = 0.458, X^{2}=1......
chisquare test, genotypic Pvalue = 0.458, X^{2}=1.561, allelic Pvalue = 0.808, X^{2}=0.059 in the MDD patients; genotypic Pvalue = 0.558, X^{2}=1.158, allelic Pvalue = 0.460, X^{2}=0.545 in MDD and BID patients
More...

There were no differences in the distribution of the genoty......
There were no differences in the distribution of the genotypes and alleles of the NQO1 C609T polymorphism between the MDD patients and the controls. The combined analysis of the MDD and BID patients did not reveal any significant association between the genotypes and allele distributions of the patients and controls.
More...

Negative

Pae, C. U., 2007 (b) 

GABRA1 181A/G 
GABRA1 
1(0/0/1)

1

Association analysis:genotype Pvalue = 0.53, allele Pvalu......
Association analysis:genotype Pvalue = 0.53, allele Pvalue = 0.56
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Horiuchi, Y.,2004 

GABRA1 471T/C 
GABRA1 
1(0/0/1)

1

Association analysis:genotype Pvalue = 0.99, allele Pvalu......
Association analysis:genotype Pvalue = 0.99, allele Pvalue = 0.93
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Horiuchi, Y.,2004 

GABRA1 IVS2712(GT)n 
GABRA1 
1(1/0/0)

1

Association analysis:COCAPHASE Pvalue = 0.29
Association analysis:COCAPHASE Pvalue = 0.29

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Horiuchi, Y.,2004 

GABRA1 IVS9+76A/G 
GABRA1 
1(0/0/1)

1

Association analysis:genotype Pvalue = 0.3, allele Pvalue......
Association analysis:genotype Pvalue = 0.3, allele Pvalue = 0.32
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Horiuchi, Y.,2004 

GABRA5 3'UTR 18 allele 
GABRA5 
1(1/0/0)

1

Fisher exact test, Pvalue=0.168 of patients, Pvalue=0.143......
Fisher exact test, Pvalue=0.168 of patients, Pvalue=0.143 of UP for allele 1, Pvalue=0.389 of patients, Pvalue=0.597 of UP for allele 2, Pvalue=0.138 of patients, Pvalue=0.391 of UP for allele 3, Pvalue=0.017 of patients, Pvalue=0.0065 of UP for allele 4, Pvalue=0.521 of patients, Pvalue=0.259 of UP for allele 5, Pvalue=0.225 of patients, Pvalue=0.421 for allele 6, Pvalue=0.657 of patients for allele 7, Pvalue=1 of patients, Pvalue=1 of UP for allele 8, Pvalue=0.075 of patients, Pvalue=0.096 for total, Homozygotes Pvalue=0.855 of patients, Pvalue=0.803 of UP
More...

A significant association was present in the UPR group. An ......
A significant association was present in the UPR group. An increased frequency of allele 4 was also observed in subjects with BPI disorder, but the results did not reach statistical significance.
More...

Positive

Oruc, L., 1997 ( c) 

GABRA5 (CA)n 
GABRA5 
1(1/0/0)

1

Overall Pvalue=0.043, X^{2}=15.98, df=8; UP vs. Co......
Overall Pvalue=0.043, X^{2}=15.98, df=8; UP vs. Controls: X^{2}=2.92, df=4, Pvalue=NS
More...

In the analysis between pairs of groups, a statistically si......
In the analysis between pairs of groups, a statistically significant difference was found between the BP patients and controls (P=0.004), while no such differences were observed between the groups of UP patients and controls.
More...

Positive

Papadimitriou, G. N., 1998 

GNB3 C825T 
GNB3 
1(0/0/1)

1

Association analysis:Unipolars v. controls: genotype: X
Association analysis:Unipolars v. controls: genotype: X^{2}=0.1, 2 df, Pvalue = 0.97; allele: X^{2}=0.0, 1 df, Pvalue = 0.93
More...

No significant association was observed in MDD.
No significant association was observed in MDD.

Negative

Kunugi, H.,2002 
