BDgene

Study Report

Basic Info
Reference
Citation Kurumaji, A., H. Nomoto, et al. (2001). "No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample." Am J Med Genet 105(2): 172-175.
Disease Type Bipolar Disorder & Major Depressive Disorder
Study Design case-control
Study Type Candidate-gene association study
Sample Size Controls(n=359),Depressive disorder patients(n=99),Bipolar disorder patients(n=94)
SNP/Region/Marker Size 2 variants
Predominant Ethnicity Mongloid
Population Japanese
Gender Male/female:52/42 in BD patients,40/59 in MD patients and 192/167 in controls
Age Group Adults : Mean age(SD)(year):51.4(12.4)[36.2(11.8) at age onset] in BD patients,55.9(13.2)[47.7(13.5) at age onset] in MD patients and 44.9(12.1) in controls

Detail Info

Genetic factors reported by this study for BD
Haplotypes reported by this study for BD (count: 1)

Other variants reported by this study for BD (count: 2)

Genes reported by this study for BD (count: 1)

Genetic factors reported by this study for SZ and/or MDD
Haplotypes reported by this study for SZ/MDD
Disease Markers Haplotype Related Gene(s)/Region(s) Statistical Values Description Result Category
MDD (BZRP_exon_Ala147Thr) - ( BZRP_exon_His162Arg) TSPO Haplotypic association:P-value = 0.189 No significant association was found . Negative

Other variants reported by this study for SZ/MDD
Disease Variant Name Related Gene Type Statistical Values Description Result Category
MDD TSPO exon4 His162Arg TSPO point mutation Association analysis:X2 test:genotype P-value = 0.607;allele P-value = 0.854 No significant association was observed. Negative
MDD TSPO exon4 Ala147Thr TSPO point mutation Association analysis:X2 test:genotype P-value = 0.120;allele P-value = 0.120 No significant association was observed. Negative

Genes reported by this study for SZ/MDD
Disease Gene Description Result Category
MDD TSPO In conclusion, no association between the BZRP gene and mood disorders was observed in the present study. Negative