Study Report

Basic Info
Reference |
Kurumaji, A.,2001 PMID: 11304832
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Citation |
Kurumaji, A., H. Nomoto, et al. (2001). "No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample." Am J Med Genet 105(2): 172-175.
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Disease Type |
Bipolar Disorder & Major Depressive Disorder |
Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
Controls(n=359),Depressive disorder patients(n=99),Bipolar disorder patients(n=94) |
SNP/Region/Marker Size |
2 variants |
Predominant Ethnicity |
Mongloid |
Population |
Japanese |
Gender |
Male/female:52/42 in BD patients,40/59 in MD patients and 192/167 in controls |
Age Group |
Adults
:
Mean age(SD)(year):51.4(12.4)[36.2(11.8) at age onset] in BD patients,55.9(13.2)[47.7(13.5) at age onset] in MD patients and 44.9(12.1) in controls
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Detail Info
Sample Diagnosis |
DSM |
Sample Status |
The depressive disorders were represented in 99 unrelated Japanese patients including 50 patients with a single episode of major depressive disorder (M/F=23/27), 38 patients with recurrent major depressive disorder (M/F=13/25), and 11 patients with dysthymic disorder (M/F=4/7). The bipolar disorders were represented in 94 unrelated Japanese patients including 67 patients with bipolar I disorder (M/F=36/31) and 27 patients with bipolar II disorder (M/F=16/11). A Japanese control group consisted of 359 unrelated healthy volunteers.Among the controls, 193 were paramedical staff members documented to be free of psychosis. The remainder were corporate employees who had requested annual physical examination but had not been evaluated for psychiatric disorders by a psychiatrist. |
Technique |
PCR and RFLP |
Statistical Method |
Differences in the genotype and haplotype distributions between the patient and control groups were assessed by the Monte Carlo method, using the CLUMP program with 10,000 simulations [Sham and Curtis, 1995]. |
Result Summary |
However, no statistically significant associations with either bipolar disorders or depressive disorders were observed in the allele frequencies, genotype counts, or haplotype distributions for the two variations, although the present sample size had a moderate power (0.46-0.86). These results do not suggest that the BZRP gene plays a role in the genetic predisposition of affective disorders. |

Genetic factors reported by this study for BD

Genetic factors reported by this study for SZ and/or MDD