BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	HTR4 SVRSNP1
Type	point mutation
Related Gene	HTR4
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ohtsuki, T.,2002	C/T		Association analysis:Fisher's exact test, genotype P-value = 0.03, allele P-value = 0.08, OR=1.5OR(95%CI)=1.0-2.3;Transmission disequilibrium test:NIMH pedigrees, BP-I:T/NT=43/26, chi square=4.2, P-value = 0.04;Model I:T/NT=46/30, chi square=3.4, P-value = 0.07;Model II:T/NT=51/36, chi square=1.8, P-value = 0.18;Model III:T/NT=57/45, chi square=0.7, P-value = 0.41	Significant associations were found in BPD patients.	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ohtsuki, T.,2002	Association analysis:Fisher's exact test, genotype P-value = 0.48, allele P-value = 0.28, OR=1.2OR(95%CI)=0.9-1.7;Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=43/50, chi square=0.53, P-value = 0.47	No significant association was observed in SZ.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ohtsuki, T.,2002	Association analysis:Fisher's exact test, genotype P-value = 0.001, allele P-value = 0.0007, OR=2.1OR(95%CI)=1.4-3.2	Significant associations were found in MDD.	Positive