BDgene

Other Variant Report

Basic Info
Name HTR4 SVRSNP1
Type point mutation
Related Gene HTR4
No. of Study 1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES

Variant related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Ohtsuki, T.,2002 C/T Association analysis:Fisher's exact test, genotype P-value = 0.03, allele P-value = 0.08, OR=1.5OR(95%CI)=1.0-2.3;Transmission disequilibrium test:NIMH pedigrees, BP-I:T/NT=43/26, chi square=4.2, P-value = 0.04;Model I:T/NT=46/30, chi square=3.4, P-value = 0.07;Model II:T/NT=51/36, chi square=1.8, P-value = 0.18;Model III:T/NT=57/45, chi square=0.7, P-value = 0.41 Significant associations were found in BPD patients. Positive

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Ohtsuki, T.,2002 Association analysis:Fisher's exact test, genotype P-value = 0.48, allele P-value = 0.28, OR=1.2OR(95%CI)=0.9-1.7;Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=43/50, chi square=0.53, P-value = 0.47 No significant association was observed in SZ. Negative

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Ohtsuki, T.,2002 Association analysis:Fisher's exact test, genotype P-value = 0.001, allele P-value = 0.0007, OR=2.1OR(95%CI)=1.4-3.2 Significant associations were found in MDD. Positive