Reference 
Allele Change 
Risk Allele 
Statistical Values 
Author Comments 
Result Category 
Chepenik, L. G.,2009 
Val66Met 

The ROI analyses:1.genotype:Pvalue < 0.001, Carriers of the BDNF met alleleï¼šLSmeanmet=2433, SEmet=115; LSmeanval=2950, SEval=86.BD met carriers: LSmeanHCval=3166, SE=134; LSmeanHCmet=2683, SE=178; LSmeanBDval=2734, SE=125; LSmeanBDmet=2181, SE=149 2.group:Pvalue < 0.01, Casecontrol:LSmeanBD=2458, SEBD=100;LSmeanHC=2925, SEHC=100.

We found that hippocampus volumes were significantly smaller.....
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We found that hippocampus volumes were significantly smaller in BD compared to HC subjects, and presence of the BDNF met allele was associated with smaller hippocampus volume in both diagnostic groups. The BD subgroup who carried the BDNF met allele had the smallest hippocampus volumes, and threedimensional mapping identified these decreases as most prominent in left anterior hippocampus.
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Positive

Chen, S. L., 2014 
Met/Val 

Genotype: Pvalue=0.155 for BP1 patients, Pvalue=0.112 for BPII patients. Alley frequency: Pvalue=0.249 for BP1 patients, Pvalue=0.255 for BPII patients.

the distribution of the BDNF Val66Met SNP was not different .....
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the distribution of the BDNF Val66Met SNP was not different between groups.
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Negative

Huang, C. C.,2012 
Val/Met 

allelic Pvaue=0.13, X^{2}=4.09; genotypic Pvalue=0.21, X^{2}=5.91

The BDNF Val66Met polymorphism was not associated with eithe.....
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The BDNF Val66Met polymorphism was not associated with either BPI or BPII, in both genotypic and allelic distribution.
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Negative

Tang, J., 2008 
C/T 

Genotypic X^{2}=1.538 (df=2), Pvalue = 0.463; Allelic X^{2}=1.277 (df=1), Pvalue = 0.285

No significant difference was found in the frequency of the .....
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No significant difference was found in the frequency of the genotype or allele in this polymorphism between patients and controls.
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Negative

Skibinska, M., 2004 
Val/Met 

bipolar I+II vs. control (males and females) c2 =1.831, df=2, p=0.4 for genotypes, p=0.406 for alleles; bipolar I+II vs. control (males)c 2 =0.399, df=2, p=0.819 for genotypes, p=0.673 for alleles; bipolar I+II vs. control (females) c 2 =1.678, df=2, p=0.432 for genotypes, p=0.464 for alleles.

The allele and genotype distribution for the patients with s.....
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The allele and genotype distribution for the patients with schizophrenia or bipolar affective disorder did not differ significantly from controls. When groups were separated according to gender, there was also not any significant difference in allele and genotype distribution.
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Negative

Tramontina, J., 2007 
Val/Met 

chisquare Pvalue > 0.05

No significant differences were found in the frequency of th.....
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No significant differences were found in the frequency of the BDNF val66met genotype or allele distribution between patients and controls.
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Negative

Matsuo, K.,2009 
Val66Met 

Imaging Data:Val/Val and Val/Met subjects (casecontrol), ACC GM volumes:left ACC, x= 7, y=13, z=25, t=3.55, k=66, P=0.011; right ACC, x=12, y=25, z=23, t=3.24, k=133, P=0.013.Threeway interaction:left ACC, F1, 76=1.15, P=0.29;right ACC, F1, 76=1.16, P=0.69.The diagnosis by genotype interaction:left ACC, F1, 76=5.69, P=0.02; right ACC, F1, 76=5.03, P=0.03.CVLT Performance:for diagnosis (F1, 69=4.39, P=0.04), for genotype (F1, 69=0.82, P=0.63), for the interaction between diagnosis and genotype (F4.1, 283.3=0.86, P=0.48).

Left and right anterior cingulate GM volumes showed a signif.....
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Left and right anterior cingulate GM volumes showed a significant interaction between genotype and diagnosis such that anterior cingulate GM volumes were significantly smaller in the Val/Met BD patients compared with the Val/Val BD patients. Withingroup comparisons revealed that the Val/Met carriers showed smaller GM volumes of the dorsolateral prefrontal cortex compared with the Val/Val subjects within the BD patient and healthy groups. The Val/Met healthy subjects had smaller GM volumes of the left hippocampus compared with the Val/Val healthy subjects. There was a significant main effect of diagnosis on memory function (P=0.04), but no interaction between diagnosis and genotype was found.
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Positive

Nassan, M., 2015 
Val/Met 


Comparison of adult BD cases with controls provided nonsigni.....
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Comparison of adult BD cases with controls provided nonsignificant evidence of association of the minor Met allele of Val66Met with BD(OR = 1.19, p = 0.06). However, comparison of TEAM earlyonset cases with controls showed a stronger association of the minor allele with EOBD (OR = 1.55, p = 0.04). Although comparison of adult EOBD cases from the Mayo Clinic BD Biobank with controls was not statistically significant, the OR estimate indicated the same direction of effect (OR = 1.21, p = 0.19). When earlyonset adult BD cases from the Mayo BD Biobank and TEAM earlyonset cases were together compared with the controls, the association of the minor allele of rs6265 with EOBD was statistically significant (OR = 1.30, p = 0.04).
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Positive

Sklar, P.,2002 
Val66Met 

Association analysis:TDT, Hopkins sample, T/NT=53/34, chi square=4.1, Pvalue = 0.042, OR=1.56, OR(95%CI)=1.052.47;NIMH sample, T/NT=70/55, chi square=1.8, Pvalue = 0.09, OR=1.27, OR(95%CI)=0.921.84;UK sample, T/NT=38/32, chi square=0.51, Pvalue = 0.237, OR=1.19, OR(95%CI)=0.771.96;Replication samples(NIMH+UK), T/NT=108/87, chi square=2.26, Pvalue = 0.066, OR=1.24, OR(95%CI)=0.951.66

Significant associations were found in Hopkins sample.

Positive

NevesPereira, M.,2002 
val66met 

Association analysis:FBAT, allele A, Z score=3.415, Pvalue = 0.00064;allele G, Z score=3.415, Pvalue = 0.00064

Significant associations were found in BPD patients.

Positive

Hamshere, M. L.,2012 
Val66Met 

Logistic Regression Analysis:for Val/Val, OR=1.1, 95%CI=0.472.60, Pvalue = 0.82 in BPI;;OR=0.4, 95%CI=0.160.97, Pvalue = 0.04* in BPII.For Val/Met, OR=1.18, 95%CI=0.542.58, Pvalue = 0.67 in BPI;;OR=1.39, 95%CI=0.692.80, Pvalue = 0.36 in BPII

Significant association was observed in BPII.

Positive

De Luca, V.,2008 

G 
The Val66 (G) allelewas transmitted more frequently with BD (maternal meioses: 46/22, p = 0.003; paternal meioses: 55/30, p = 0.006).

Significant genetic association between BD and the BDNF Val6.....
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Significant genetic association between BD and the BDNF Val66Met SNP was detected
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Positive

Lee, S. Y.,2012(b) 
Val/Met 
Val 
Chi square test:genotype,Pvalue = 0.79,chi square = 1.73;allele,Pvalue = 0.64,chi square = 0.88

No evidence support the association of this variant with BD

Negative

Kunugi, H.,2004 
Val66Met 

Association analysis:chi square test, Genotypewise comparisons: total patients vs. control subjects:chi square=0, Pvalue = 0.98; bipolar I vs. control subjects: chi square=0.3, Pvalue = 0.86; bipolar II vs. control subjects: chi square=0.8, Pvalue = 0.69. Allelewise comparisons: total patients vs. control subjects: chi square=0.0, Pvalue = 0.83; bipolar I vs. control subjects: chi square=0.0, Pvalue = 0.96; bipolar II vs. control subjects:chi square=0.0, Pvalue = 0.94.

No significant association was observed in BD.

Negative

Muller, D. J., 2006 
A/G 

TDTPHASE Pvalue = 0.001, df=1, LRS=10.62; Pvalue = 0.01 for bipolar disorder I, Pvalue = 0.02 for bipolar disorder II

Significant association between the total sample and the BDN.....
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Significant association between the total sample and the BDNF gene was found for Val66Met. Overtransmission was observed for the Val (or G) allele of Val66Met. When participants with bipolar disorder were divided into two groups (bipolar disorder I and II), a significant association was found for the Val66Met polymorphism of the BDNF gene.
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Positive

Lee, S. Y.,2012(a) 
Val/Met 
Val 
Chi square test:genotype,Pvalue = 0.75,chi square = 1.94;allele,Pvalue = 0.83,chi square = 0.37

No evidence support the association of this variant with BD

Negative

Mick, E.,2009 
Val/Met 
Val 
TDT:OR=1.23, 95%CI=0.791.92, X^{2}=0.8, Pvalue = 0.37

We failed to identify significant associations with this can.....
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We failed to identify significant associations with this candidate.
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Negative

Hong, C. J.,2003 
Val66Met 

Association analysis:genotype Pvalue = 0.762, allele Pvalue = 0.489

No significant association was observed in BD.

Negative

Green, E. K., 2006 
Val/Met 

allelic Pvalue = 0.39, X^{2}=0.73, df=1, OR (95% CI)=1.07 (0.921.22), genotypic Pvalue = 0.68, X^{2}=0.77, df=2 for Bipolar I and II disorder; allelic Pvalue = 0.36, X^{2}=0.83, df=1, OR (95% CI)=1.07 (0.931.24), genotypic Pvalue = 0.64, X^{2}=0.89, df=2 for Bipolar I disorder; allelic Pvalue = 0.98, X^{2}=0.00, df=1, OR (95% CI)=1.00 (0.701.45), genotypic Pvalue = 0.96, X^{2}=0.09, df=2 for Bipolar II disorder; allelic Pvalue = 0.0040, X^{2}=8.28, df=1, OR (95% CI)=1.74 (1.192.56), genotypic Pvalue = 0.015, X^{2}=8.47, df=2 for rapidcycling bipolar disorder; reanalysis Pvalue < 0.03, onetailed test

No differences in allele or genotype frequencies were seen b.....
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No differences in allele or genotype frequencies were seen between cases and controls for any of the diagnostic groups. However, we found association with disease status in the subset of rapid cycling. We found a similar association on reanalysis of the previously reported familybased association sample.
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Positive

Geller, B.,2004 
Val66Met 

Association analysis:FBAT, chi square=6.0, 1df, Pvalue = 0.14

Significant association was found in BPD patients.

Positive

Chang, Y. H.,2013 
Val66Met 

Met/Val:BDII without AD, OR = 0.64,95%CI = 0.17â€“2.36, Pvalue = 0.5;BDII without AD, OR = 1.33m95%CI = 0.23â€“7.60, Pvalue = 0.74;Val/Val:BDII without AD, OR = 0.55,95%CI = 0.20â€“1.51, Pvalue = 0.25;BDII without AD, OR = 0.48,95%CI = 0.10â€“2.18, Pvalue = 0.34;Met/Val:BDI without AD, OR = 0.82,95%CI = 0.20â€“3.35, Pvalue = 0.5;BDI without AD, OR = 1.23,95%CI = 0.06â€“23.75, Pvalue = 0.89Val/Val:BDI without AD, OR = 0.3,95%CI = 0.09â€“1.02, Pvalue = 0.05;BDI without AD, OR = 2330000000,95%CI = 6.34E+09â€“8.54E+08, Pvalue = 0.0005

Significant association was observed.

Positive
