BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	HTR2C Cys23Ser
Type	point mutation
Related Gene	HTR2C
No. of Study	3 (Positive: 3; Negative 0; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Variant related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Kumar, H. B., 2007	G/C		allelic X² (df=1)=4.413, P-value = 0.035	The 5-HT2C Cys23Ser allele frequencies showed a marginal dis..... More The 5-HT2C Cys23Ser allele frequencies showed a marginal disease association on comparing the BPAD with controls Less	Positive
Lerer, B.,2001	cys23ser	23ser	Association analysis:Logistic regression, chi square= 5.45, df 1, P-value = 0.02	Significant associations were found in BPD patients.	Positive
Massat, I., 2007			P-value = 0.004, OR=2.1, 95%CI=1.3-3.4 in EO-BP patients compared to controls; P-value = 0.039, OR=1.7, 95%CI=1.02-2.9 in EO-BP patients compared to BP with AAO>16	A significant association emerged with an excess of HTR2C Se..... More A significant association emerged with an excess of HTR2C Ser23 allele in EO-BP patients compared to controls and BP with AAO>16. No difference was shown between BP group with AAO>16 years and controls. Less	Positive

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Lerer, B.,2001	Association analysis:Logistic regression, chi square= 7.34, df 1, P-value = 0.006	Significant associations were found in MDD patients.	Positive