Study Report

Basic Info

Reference	Hong, C. J.,2003 PMID: 14673216
Citation	Hong, C. J., S. J. Huo, et al. (2003). "Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior." Neuropsychobiology 48(4): 186-189.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	84 MD patients,108 BPD patients and 392 normal controls
SNP/Region/Marker Size	1 variant
Predominant Ethnicity	Mongloid
Population	Chinese(Taiwan)
Gender	Male/female:75/117 for mood disorder patients,161/231 for controls
Age Group	Adults : Mean age(SD)(year)44.1(15.9) for mood disorder patients and 44.8(21.4) for controls

Detail Info

Sample Diagnosis	DSM
Sample Status	The study group included 192 patients.A total of 174 of these 192 subjects(90.6%) were psychiatric inpatients.For comparison,392 normal subjects who had agreed to be interviewed by a member of psychiatric staff to rule out psychotic or mood disorders were also enrolled to test the association between the BDNF polymorphism and mood disorders in the dysfunctional subjects.The study population consisited entirely of ethnic Chinese people who had given written, informed consents.
Technique	PCR and RFLP
Statistical Method	the Chi-square test ,Fisher's exact test and the Student's t-test
Result Summary	The genotype and allele frequencies for the BDNF gene Val66Met polymorphism did not differ comparing depression groups (total, bipolar disorder or major depression) and control subjects. Furthermore, it was not demonstrated that this BDNF polymorphism was associated with age of onset or suicidal history in our mood disorder patients. Based on these results, it seems reasonable to suggest that this polymorphism is unlikely to play a major role in the genetic susceptibility to mood disorders. Given the fact that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or our Chinese sample, it appears likely that this association is ethnicity dependent.

Genetic factors reported by this study for BD

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
BDNF Val66Met	BDNF	point mutation	Val66Met		Association analysis:genotype P-value = 0.762, allele P-value = 0.489	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
BDNF	Given the fact that the positive association between BDNF gene Val66Met polymorphism and bipolar dis...... Given the fact that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or our Chinese sample, it appears likely that this association is ethnicity dependent. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

Other variants reported by this study for SZ/MDD

Disease	Variant Name	Related Gene	Type	Statistical Values	Description	Result Category
MDD	BDNF Val66Met	BDNF	point mutation	Association analysis:genotype P-value = 0.598, allele P-value = 0.497	No significant association was observed in MDD.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	BDNF	Given the fact that the positive association between BDNF gene Val66Met polymorphism and bipolar disorder has only been demonstrated for a Caucasian population but not for a Japanese analog or our Chinese sample, it appears likely that this association is ethnicity dependent.	Negative