BDgene

Other Variant Report

Basic Info
Name HTR4 SVRSNP4
Type point mutation
Related Gene HTR4
No. of Study 1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES

Variant related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Ohtsuki, T.,2002 C/T Association analysis:Fisher's exact test, genotype P-value = 0.001, allele P-value = 0.05, OR=1.6OR(95%CI)=1.0-2.6;Transmission disequilibrium test:NIMH pedigrees, BP-I:T/NT=36/18, chi square=6, P-value = 0.01;Model I:T/NT=41/21, chi square=6.5, P-value = 0.01;Model II:T/NT=46/28, chi square=2.6, P-value = 0.11;Model III:T/NT=51/35, chi square=1.6, P-value = 0.24 Significant associations were found in BPD patients. Positive

Overlap with SZ from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Ohtsuki, T.,2002 Association analysis:Fisher's exact test, genotype P-value = 0.34, allele P-value = 0.16, OR=1.3OR(95%CI)=0.9-2.0;Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=34/45, chi square=1.53, P-value = 0.22 No significant association was observed in SZ. Negative

Overlap with MDD from cross-disorder studies (count: 1)
Reference Statistical Result Description Result Category
Ohtsuki, T.,2002 Association analysis:Fisher's exact test, genotype P-value = 0.03, allele P-value = 0.15, OR=1.4OR(95%CI)=0.9-2.3 Significant associations were found in MDD. Positive