BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	HTR4 SVRSNP4
Type	point mutation
Related Gene	HTR4
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ohtsuki, T.,2002	C/T		Association analysis:Fisher's exact test, genotype P-value = 0.001, allele P-value = 0.05, OR=1.6OR(95%CI)=1.0-2.6;Transmission disequilibrium test:NIMH pedigrees, BP-I:T/NT=36/18, chi square=6, P-value = 0.01;Model I:T/NT=41/21, chi square=6.5, P-value = 0.01;Model II:T/NT=46/28, chi square=2.6, P-value = 0.11;Model III:T/NT=51/35, chi square=1.6, P-value = 0.24	Significant associations were found in BPD patients.	Positive

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ohtsuki, T.,2002	Association analysis:Fisher's exact test, genotype P-value = 0.34, allele P-value = 0.16, OR=1.3OR(95%CI)=0.9-2.0;Transmission disequilibrium test:Schizophrenia(RIKEN families):T/NT=34/45, chi square=1.53, P-value = 0.22	No significant association was observed in SZ.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Ohtsuki, T.,2002	Association analysis:Fisher's exact test, genotype P-value = 0.03, allele P-value = 0.15, OR=1.4OR(95%CI)=0.9-2.3	Significant associations were found in MDD.	Positive