Study Report

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Basic Info

Reference	Pae, C. U., 2006 PMID: 16626843
Citation	Pae, C. U., S. J. Yoon, et al. (2006). "Manganese superoxide dismutase (MnSOD: Ala-9Val) gene polymorphism and mood disorders: a preliminary study." Prog Neuropsychopharmacol Biol Psychiatry 30(7): 1326-1329.
Disease Type	Bipolar I Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	80 patients with BD, 61 patients with MDD and 106 controls
SNP/Region/Marker Size	1 SNP
Predominant Ethnicity	Mongloid
Population	Korean
Gender	24 male patients with MDD, 41 male patients with BD, 51 male controls
Age Group	adults : mean age=47.1 years (S.D.=15.3) of MDD patients, mean age=34.4 years (S.D.=12.7) of BD patients, mean age=33.8 years (S.D.=11.5) of controls

Detail Info

Sample Diagnosis	DSM-IV
Sample Status	Eighty patients with BD, 61 patients with MDD and the 106 controls were enrolled in this study. The family history, prior history of suicide attempts and psychotic episodes, and the age at onset (the subjects had a precise history of psychiatric evaluations and treatments from psychiatrists) were also obtained. Subjects with any other axis I and II disorders and current neurological and medico-surgical illnesses were excluded.
Technique	genotyping
Statistical Method	The genotype and allele distribution in Ala-9Val MnSOD polymorphism of patients and the control groups was compared using either a Chi-squared test or Fisher's exact test. P values < 0.05 were considered significant. All the statistical tests were performed using SPSS v10.0 software. The power of a sample to detect any difference between the two variants was calculated using a two-tailed alpha value of 0.05.
Result Summary	The patients with MDD and BD, and the controls had a similar distribution of the genotypes and alleles in the Ala-9Val MnSOD polymorphism. The combined analysis (MDD plus BD) also failed to find any association between the Ala-9Val MnSOD polymorphism and mood disorders. Subgroup analyses according to the clinical variables such as the family history, age at onset, psychotic features and suicide history failed to identify any association with the Ala-9Val MnSOD polymorphism. This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphism is not associated with the development of mood disorders or their clinical parameters. However, more study with a larger population sample will be needed.

Genetic factors reported by this study for BD

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
SOD2 Ala-9Val	SOD2	point mutation	Ala/Val		genotypic P-value = 0.484, X²=1.493; allelic P-value = 0.512, X²=0.431 between BD patients and controls; genotypic P-value = 0.369, X²=1.99, allelic P-value = 0.266, X²=1.24 in the combined patient group and controls	The genotype and allele distribution of the Ala-9Val MnSOD p...... The genotype and allele distribution of the Ala-9Val MnSOD polymorphism was similar in the BD patients and controls. Moreover, the distribution of genotypes and alleles in the Ala-9Val MnSOD polymorphism were similar in the combined patient group (MDD plus BD) and controls. More...	Negative

Genes reported by this study for BD (count: 1)

Gene	Statistical Values/Author Comments	Result Category
SOD2	This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphi...... This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphism is not associated with the development of mood disorders or their clinical parameters. However, more study with a larger population sample will be needed. More...	Negative

Genetic factors reported by this study for SZ and/or MDD

Other variants reported by this study for SZ/MDD

Disease	Variant Name	Related Gene	Type	Statistical Values	Description	Result Category
MDD	SOD2 Ala-9Val	SOD2	point mutation	genotypic P-value = 0.144, X²=1.561; allelic P-value = 0.199, X²=1.650 between MDD patients and controls; genotypic P-value = 0.369, X²=1.99, allelic P-value = 0.266, X²=1.24 in the combined patient group and controls	The genotype and allele distribution of the Ala-9Val MnSOD polymorphism was similar in the MDD patients and controls. Moreover, the distribution of genotypes and alleles in the Ala-9Val MnSOD polymorphism were similar in the combined patient group (MDD plus BD) and controls.	Negative

Genes reported by this study for SZ/MDD

Disease	Gene	Description	Result Category
MDD	SOD2	This preliminary data suggests that at least in the Korean population, the Ala-9Val MnSOD polymorphism is not associated with the development of mood disorders or their clinical parameters. However, more study with a larger population sample will be needed.	Negative