BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Other Variant Report

Basic Info

Name	BDNF (GT)n
Type	microsatellite
Related Gene	BDNF
No. of Study	3 (Positive: 2; Negative 1; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Variant related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Neves-Pereira, M.,2002	multi-allelic repeats		Association analysis:FBAT, allele 1, Z score=-0.953, P-value = 0.34;allele 2, Z score=-1, P-value = 0.317;allele 3, Z score=2.035, P-value = 0.042;allele 4, Z score=-1.038, P-value = 0.299	Significant associations were found in BPD patients.	Positive
Muller, D. J., 2006			TDTPHASE P-value = 0.17, df=8, LRS=11.66; TDTPHASE P-value = 0.008, df=1, LRS=6.87 for allele 3 vs other alleles	Significant association between the total sample and the BDN..... More Significant association between the total sample and the BDNF gene was found for GT(n) repeat polymorphism. Over-transmissions was observed for allele 3 of the GT(n) repeat. Less	Positive
Schumacher, J.,2005	(GT)n repeat		Allele distribution:in Bonn sample, for BPAD, global P-value = 0.730	No significant association was observed.	Negative

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Schumacher, J.,2005	Allele distribution:in Bonn sample, for Schizophrenia, global P-value = 0.350	No significant association was observed.	Negative

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Schumacher, J.,2005	Allele distribution:in Bonn sample, for MDD, P-value = 0.028;in Munich sample, for MDD, P-value = 0.084	Significant association was found in Bonn sample.	Positive