Study Report

Reference	Arias, B., 2001 PMID: 11311505
Citation	Arias, B., D. A. Collier, et al. (2001). "Genetic variation in the 5-HT5A receptor gene in patients with bipolar disorder and major depression." Neurosci Lett 303(2): 111-114.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	181 patients with major depression, 88 patients with bipolar affective disorder (BP) and 157 unrelated controls ?
SNP/Region/Marker Size	2 variants
Predominant Ethnicity
Population	Spanish
Gender	55 men and 126 females with MD,37 men and 51 female with bipolar affective disorder (BP),81 men and 82 female with control
Age Group	Adults : 52.13(16.63) for MD patients and 44.8(14.9) for BD patients

Sample Diagnosis	DSM
Technique	PCR and RFLP
Statistical Method	X2 test
Result Summary	No genotype, allele or haplotype differences were found when we compared patients and controls. When clinical variables were considered as possible tools for detecting genetic heterogeneity, no differences were found. Our results suggest that the polymorphisms analyzed in the 5-HT5A receptor gene do not play a major role in the pathogenesis of affective disorders.