BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Other Variant Report

Basic Info

Name	GABRA5 (CA)n
Type	polymorphic dinucleotide repeat marker
Related Gene	GABRA5
No. of Study	1 (Positive: 1; Negative 0; Trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Variant related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Papadimitriou, G. N., 1998			Overall P-value=0.043, X²=15.98, df=8; BP vs. Controls: X²=15.22, df=4,P-value=0.004; allelic P-value=0.007, X²=7.30 for 282bp; P-value=0.30, X²=0.88 for 284bp; P-value=0.10, X²=2.51 for 286bp; P-value=0.90, X²=0.01 for 288bp; P-value=0.002, X²=9.84, df=1 for distribution of genotypes with presence or absence of the 282-base pairs allele in BP patients; multiple linear regression of BD from genotype, P-value=0.008, t=2.705	In the analysis between pairs of groups, a statistically sig..... More In the analysis between pairs of groups, a statistically significant difference was found between the BP patients and controls. The finding regarding the difference in the allelic frequencies between BP patients and controls remained significant (P<0.02) after the correction. The 282-bp allele was the only one found to be positively associated with BP affective disorder at a significant level. This significance persisted after the Bonferroni correction (P=0.028). Regarding the distribution of genotypes in BP patients and controls, a statistically significant association existed between the 282-bp allele containing genotypes and BP disorder. The multiple regression analysis also showed that the genotype containing the 282-bp allele was significantly associated with BP disorder (P 4 0.008). Less	Positive

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Papadimitriou, G. N., 1998	Overall P-value=0.043, X²=15.98, df=8; UP vs. Controls: X²=2.92, df=4, P-value=NS	In the analysis between pairs of groups, a statistically significant difference was found between the BP patients and controls (P=0.004), while no such differences were observed between the groups of UP patients and controls.	Positive