Study Report

Reference	Hong, C. J.,1999 PMID: 10581475
Citation	Hong, C. J., S. J. Tsai, et al. (1999). "Association analysis of the 5-HT(6) receptor polymorphism (C267T) in mood disorders." Am J Med Genet 88(6): 601-602.
Disease Type	Bipolar Disorder & Major Depressive Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	139 patients with mood disorders(62 BD patients and 77 MDD patients) and 147 controls
SNP/Region/Marker Size	1 variant
Predominant Ethnicity	Mongloid
Population	Chinese
Gender	26 men and 36 women in bipolar patients,36 men and 41 women in patients with major depression,69 male and 78 female in controls
Age Group	Adults : Mean age(SD)(year):37.0(12.8) for BD patients;45.8(18.5) for MDD patients and 34.9(7.6) for controls

Sample Diagnosis	DSM
Sample Status	The patient groups were inpatients at Veterans General Hospital-Taipei.Consensus diagnosis based on interview, clinical observation,medical record, and past history by two psychiatrists according to the DSM-IV criteria was made for each patient. A total of 147 normal comparison subjects who accepted a semistructure interview by a psychiatric staff to rule out psychiatric problems were included to test the association of the 5-HT6 C267T polymorphism with mood disorders.The sample was all ethnic Chinese.
Technique	PCR and RFLP
Statistical Method	Chi-square tests
Result Summary	The results demonstrated that there were no significant differences in genotype or allele frequencies between controls and all patients, or between controls and patients with bipolar disorders or major depression, separately.