BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Other Variant Report

Basic Info

Name	TPH1 A218C
Type	point mutation
Location	intron 7
Related Gene	TPH1
No. of Study	6 (Positive: 2; Negative 4; Trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Variant related studies (count: 6)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Serretti, A.,2001(a)	A218C		Association analysis:chi sauqre test, TPH_A/A, chi square=9.35, d.f.=2, P-value = 0.01	Significant association was found in BPD patients.	Positive
Souery, D.,2001	A218C		Association analysis:Chi square tests:alleles, X²= 0.03, P-value = 0.86; genotypes X²= 0.69, P-value = 0.708	No significant association was observed in BD.	Negative
Rotondo, A.,2002	C>A		Association analysis:genotype, chi square(2df)=3.82, P-value = 0.15, allele, chi square(1df)=2.56, P-value = 0.11	No significant association was observed in BD.	Negative
Bellivier, F., 1998 (a)	A/C		(a) vs (b) for genotypic distribution, X²=12.23, df=2, P-value=0.002; (a) vs (b) for allelic distribution, X²=12, df=1, P-value=0.001; (c) vs (d) for allelic distribution, X²=1.46, df=1, P-value=0.22; (e) vs (f) for allelic distribution, X²=0.03, df=1, P-value=0.86	There was an association between TPH genotype and manicdepre..... More There was an association between TPH genotype and manicdepressive illness (x2=12.23, df=2; P,.02). The allelic distributions for patients and controls were significantly different (x2=12.00, df=1; P=.001). Less	Positive
Serretti, A.,2002	A218C		Association analysis:TDT, P-value = 0.745	No significant association was observed.	Negative
Rietschel, M.,2000	A218C		Association analysis: TDT=0.04; P-value = 0.92	No significant association was observed.	Negative

Overlap with SZ from cross-disorder studies (count: 1)

Reference	Statistical Result	Description	Result Category
Serretti, A.,2001(a)	Association analysis:chi sauqre test, P-value > 0.05	No significant association was observed in SZ.	Negative

Overlap with MDD from cross-disorder studies (count: 2)

Reference	Statistical Result	Description	Result Category
Souery, D.,2001	Association analysis:Chi square tests:alleles, X²= 0.205, P-value = 0.65; genotypes X²= 0.55, P-value = 0.757	No significant association was observed in MDD.	Negative
Serretti, A.,2001(a)	Association analysis:chi sauqre test, P-value > 0.05	No significant association was observed in MDD.	Negative