Hot Gene List

Search by: Type = Gene, No. of All Studies>=5

Total result: 62

Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend) Overlap with SZ Overlap with MDD All Help
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 17q11.2 44(18/26/0) YES YES
BDNF brain-derived neurotrophic factor 11p14.1 37(24/12/1) YES YES
COMT catechol-O-methyltransferase 22q11.21 28(14/14/0) YES YES
DRD2 dopamine receptor D2 11q22-q23 28(8/20/0) YES YES
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 22(7/15/0) YES YES
DAOA D-amino acid oxidase activator 13q33.2 21(13/7/1) YES YES
MAOA monoamine oxidase A Xp11.4-p11.3 21(10/11/0) YES YES
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 20(17/3/0) YES YES
DRD3 dopamine receptor D3 3q13.3 19(4/15/0) YES YES
DISC1 disrupted in schizophrenia 1 1q42.1 18(10/7/1) YES YES
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 17(13/3/1) YES YES
TH tyrosine hydroxylase 11p15.5 16(4/12/0) YES YES
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1p36.3 16(10/6/0) YES YES
NRG1 neuregulin 1 8p12 15(10/5/0) YES YES
TPH1 tryptophan hydroxylase 1 11p15.3-p14 14(5/9/0) YES YES
TPH2 tryptophan hydroxylase 2 12q15 13(10/3/0) YES YES
DRD4 dopamine receptor D4 11p15.5 13(1/12/0) YES YES
CLOCK clock circadian regulator 4q12 12(5/7/0) YES YES
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 11(5/6/0) YES YES
DRD1 dopamine receptor D1 5q34-q35 11(6/5/0) YES YES
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 12q24 9(2/7/0) YES YES
GSK3B glycogen synthase kinase 3 beta 3q13.3 8(0/8/0) YES YES
DTNBP1 dystrobrevin binding protein 1 6p22.3 8(4/3/1) YES YES
NOS1 nitric oxide synthase 1 (neuronal) 12q24.22 8(2/5/1) YES YES
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p13.1 8(4/4/0) YES YES
WFS1 Wolfram syndrome 1 (wolframin) 4p16.1 7(1/6/0) YES YES
PER2 period circadian clock 2 2q37.3 7(1/6/0) YES YES
GRM3 glutamate receptor, metabotropic 3 7q21.1-q21.2 7(3/4/0) YES YES
PER3 period circadian clock 3 1p36.23 7(3/4/0) YES YES
ARNTL aryl hydrocarbon receptor nuclear translocator-like 11p15 7(5/2/0) YES YES
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1q21.3 7(1/6/0) YES YES
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 7(4/3/0) YES YES
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 18p11.22 6(5/1/0) YES NO
ZNF804A zinc finger protein 804A 2q32.1 6(3/3/0) YES NO
SYNE1 spectrin repeat containing, nuclear envelope 1 6q25.2 6(3/2/1) YES YES
NR1D1 nuclear receptor subfamily 1, group D, member 1 17q11.2 6(2/4/0) YES YES
TENM4 teneurin transmembrane protein 4 11q13 6(4/2/0) YES YES
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 16p13.3 6(2/2/2) NO NO
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 15q12 6(6/0/0) YES YES
RGS4 regulator of G-protein signaling 4 1q23.3 6(3/2/1) YES YES
DGKH diacylglycerol kinase, eta 13q13.3 6(3/3/0) YES YES
TCF4 transcription factor 4 18q21.1 6(1/5/0) YES NO
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 7p22 5(1/2/2) YES NO
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1 22q13.33 5(1/4/0) YES YES
SORCS2 sortilin-related VPS10 domain containing receptor 2 4p16.1 5(3/2/0) NO NO
PALB2 partner and localizer of BRCA2 16p12.1 5(2/2/1) YES NO
TAAR6 trace amine associated receptor 6 6q23.1 5(4/1/0) YES YES
NPAS2 neuronal PAS domain protein 2 2q11.2 5(3/2/0) YES YES
PDLIM5 PDZ and LIM domain 5 4q22 5(4/1/0) YES YES
CSNK1E casein kinase 1, epsilon 22q13.1 5(1/3/1) YES YES
CNR1 cannabinoid receptor 1 (brain) 6q14-q15 5(0/5/0) YES YES
PBRM1 polybromo 1 3p21 5(4/0/1) YES YES
TRPM2 transient receptor potential cation channel, subfamily M, member 2 21q22.3 5(3/2/0) NO NO
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 5q31-q32 5(2/3/0) YES YES
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 7p12.1 5(2/3/0) YES YES
FKBP5 FK506 binding protein 5 6p21.31 5(1/4/0) YES YES
ACE angiotensin I converting enzyme 17q23.3 5(2/3/0) YES YES
DAO D-amino-acid oxidase 12q24.11 5(1/4/0) YES NO
CRY2 cryptochrome circadian clock 2 11p11.2 5(3/2/0) YES YES
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 3p22.2 5(2/1/2) YES NO
PER1 period circadian clock 1 17p13.1 5(2/3/0) YES YES
DUSP6 dual specificity phosphatase 6 12q22-q23 5(3/2/0) YES YES