GO Report

Basic Info

ID	GO:0045087
Name	innate immune response
Type	biological process
No. of Genes in BDgene	49
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
INNATE IMMUNE RESPONSE	i-GSEA analysis	From NIMH	Trinity College Dublin	i-GSEA by using i-GSEA4GWAS	P-value=0.001, FDR=0.028333334	Link in i-GSEA4GWAS

GO related genes in BDgene (count: 49)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)	Evidence[PMID]
FYN	FYN proto-oncogene, Src family tyrosine kinase	6q21	1(1/0/0)	IBA; TAS
P2RX7	purinergic receptor P2X, ligand gated ion channel, 7	12q24	9(2/7/0)	TAS
TLR4	toll-like receptor 4	9q33.1	1(1/0/0)	TAS[15356140]
TNRC6B	trinucleotide repeat containing 6B	22q13	1(1/0/0)	TAS
BCL2	B-cell CLL/lymphoma 2	18q21.3	2(0/2/0)	TAS
GSK3B	glycogen synthase kinase 3 beta	3q13.3	8(0/8/0)	TAS
PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	22q13.1	2(1/1/0)	TAS
TAB2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	6q25.1	1(0/0/1)	TAS
PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	7q22	1(0/0/1)	TAS[17290298]
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha	17q24.2	1(1/0/0)	TAS
AKT1	v-akt murine thymoma viral oncogene homolog 1	14q32.33	3(3/0/0)	TAS
TRIM26	tripartite motif containing 26	6p21.3	2(2/0/0)	IDA[18248090]
EGFR	epidermal growth factor receptor	7p12	1(0/0/1)	TAS
CD36	CD36 molecule (thrombospondin receptor)	7q11.2	3(2/1/0)	TAS
PLCG1	phospholipase C, gamma 1	20q12-q13.1	1(0/1/0)	TAS
HLA-B	major histocompatibility complex, class I, B	6p21.3	2(0/1/1)	TAS
JAK1	Janus kinase 1	1p32.3-p31.3	1(0/1/0)	IBA
WIPF1	WAS/WASL interacting protein family, member 1	2q31.2	1(0/0/1)	TAS
ADCY8	adenylate cyclase 8 (brain)	8q24	4(2/1/1)	TAS
ERBB4	erb-b2 receptor tyrosine kinase 4	2q33.3-q34	2(1/1/0)	TAS
ADCY9	adenylate cyclase 9	16p13.3	2(1/1/0)	TAS
ADARB1	adenosine deaminase, RNA-specific, B1	21q22.3	1(0/1/0)	IEA
CREB1	cAMP responsive element binding protein 1	2q34	2(1/1/0)	TAS
HSP90B1	heat shock protein 90kDa beta (Grp94), member 1	12q24.2-q24.3	1(1/0/0)	TAS
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1p36.1	1(0/1/0)	TAS
PPP2R5D	protein phosphatase 2, regulatory subunit B', delta	6p21.1	1(1/0/0)	TAS
CREBBP	CREB binding protein	16p13.3	1(0/1/0)	TAS
DUSP6	dual specificity phosphatase 6	12q22-q23	5(3/2/0)	TAS
ITK	IL2-inducible T-cell kinase	5q31-q32	1(1/0/0)	IBA; TAS
MARCO	macrophage receptor with collagenous structure	2q14.2	1(0/1/0)	IEA
PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme	10q22.2	2(1/1/0)	TAS
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	14q32.33	1(1/0/0)	TAS
PRKCE	protein kinase C, epsilon	2p21	1(0/1/0)	TAS
NRG1	neuregulin 1	8p12	15(10/5/0)	TAS
TNK2	tyrosine kinase, non-receptor, 2	3q29	1(0/1/0)	IBA
CASP1	caspase 1, apoptosis-related cysteine peptidase	11q23	1(0/0/1)	TAS
FOXO3	forkhead box O3	6q21	1(1/0/0)	TAS
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	1p36	1(0/0/1)	TAS
ADCY2	adenylate cyclase 2 (brain)	5p15.3	2(1/1/0)	TAS
MAP2K6	mitogen-activated protein kinase kinase 6	17q	1(0/1/0)	TAS
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	7p22	1(1/0/0)	TAS
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	16q24.1	1(0/1/0)	TAS
LRRFIP1	leucine rich repeat (in FLII) interacting protein 1	2q37.3	1(0/1/0)	TAS
S100B	S100 calcium binding protein B	21q22.3	2(1/1/0)	TAS
MAPK10	mitogen-activated protein kinase 10	4q22-q23	1(0/1/0)	TAS
FGFR2	fibroblast growth factor receptor 2	10q25.3-q26	2(1/1/0)	TAS
NLRC5	NLR family, CARD domain containing 5	16q13	1(0/1/0)	IMP[20434986]; TAS
PIK3C3	phosphatidylinositol 3-kinase, catalytic subunit type 3	18q12.3	1(1/0/0)	TAS
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	5q13.1	1(1/0/0)	TAS