Gene Report

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Basic Info

Approved Symbol	TNRC6B
Symbol Alias	KIAA1093
Approved Name	trinucleotide repeat containing 6B
Location	22q13
Position	chr22:40044817-40335808, 1
External Links	HGNC: 29190 Entrez Gene: 23112 Ensembl: ENSG00000100354 UCSC: uc011aor.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000166	nucleotide binding	molecular function	IEA	17
GO:0031047	gene silencing by RNA	biological process	IMP[19716330]	3
GO:0000932	cytoplasmic mRNA processing body	cellular component	IEA	3
GO:0016441	posttranscriptional gene silencing	biological process	TAS	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	21
GO:0048011	neurotrophin TRK receptor signaling pathway	biological process	TAS	33
GO:0048015	phosphatidylinositol-mediated signaling	biological process	TAS	17
GO:0010467	gene expression	biological process	TAS	41
GO:0044822	poly(A) RNA binding	molecular function	IDA[22658674]	44
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	22
GO:0006417	regulation of translation	biological process	IEA	5
GO:0038095	Fc-epsilon receptor signaling pathway	biological process	TAS	19
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	biological process	IMP[19716330]	1
GO:0005515	protein binding	molecular function	IPI[17932509]	563
GO:0007219	Notch signaling pathway	biological process	TAS	14
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	biological process	IMP[19716330]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TNRC6B	UBQLN4	NO	yeast 2-hybrid	16713569

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_21	chr22:38799826-38892173 (NCBI Build 36/hg18)	92000	22q13.1	deletion

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
22q12.3-13.32	chr22:31800000-49100000	1 (0/1/0)
Chr 22	chr22:0-50818468	2 (0/1/1)
22q12.3-q13.33	chr22:31800000-50818468	1 (1/0/0)
22q13	chr22:37200000-50818468	1 (1/0/0)
22q13.1	chr22:37200000-40600000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr22:40044817..40335808 View in gBrowse