Study Report

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Basic Info

Reference	Ceulemans, S.,2011 PMID: 22085474
Citation	Ceulemans, S., S. De Zutter, et al. (2011). "Evidence for the involvement of the glucocorticoid receptor gene in bipolar disorder in an isolated northern Swedish population." Bipolar Disord 13(7-8): 614-623.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	309 BPD patients and 364 matched control individuals
SNP/Region/Marker Size	225 SNPs
Predominant Ethnicity	Caucasian
Population	Swedish
Gender	Male/female:126/183 in BD patients and 162/202 in controls
Age Group	Adults : Mean age of onset:25.9 years in BD patients

Detail Info

Sample Diagnosis	DSM
Sample Status	The BPD association sample originates from the Vasterbotten region in northern Sweden. Of these patients, 225 were diagnosed with bipolar I disorder, and 84 with bipolar II disorder. The individuals were examined at multiple time points beginning with the earliest study entry in 1992 until the present, and the majority of the patients participated in several genetic (association) studies during this time. In addition to clinical evaluations, the use of multiple informants, and the study of medical records and different semi-structured interviews were applied when feasible and deemed necessary, mainly the Mini International Neuropsychiatric Interview (MINI), the Diagnostic Interview for Genetic Studies (DIGS), the Family Interview for Genetic Studies (FIGS) (https:// www.nimhgenetics.org/interviews), and the Schedules for Clinical Assessment in Neuropsychiatry (SCAN). The final diagnosis was a best estimate consensus lifetime diagnosis based on multiple sources of information and the diagnostic criteria used were in accordance with the DSM-IV. The control individuals were randomly selected from the Betula project, a large population-based prospective study that is described in detail elsewhere. The random unrelated control population was recruited from the same geographical region as the patients.
Technique	genotyping
Statistical Method	The graphical user interface (GUI) of the PLINK package (gPLINK v1.06) (http://pngu.mgh.harvard.edu/purcell/plink) was used for single SNP analyses.HaploStats v1.3.1 software was applied for the haplotype association analyses (http://mayorese arch.mayo.edu/mayo/research/biostat/schaid.cfm).
Result Summary	RESULTS: Consistent evidence for an association with BPD was found for NR3C1, the gene encoding GR. Almost all SNPs in two adjacent haplotype blocks contributed to the positive signal, comprised of significant single marker, sliding window, and haplotype-specific p-values. All these results point to a moderately frequent (10-15%) susceptibility haplotype covering the entire coding region and 3' untranslated region (UTR) of NR3C1. CONCLUSIONS: This study contributes to the growing evidence for a role of the glucocorticoid receptor gene (NR3C1) in vulnerability to mood disorders, and BPD in particular, and warrants further in vitro investigation of the at-risk haplotypes with respect to disease etiology. However, this association might be restricted to this specific population, as it is observed in a rather small sample from an isolated population without replication, and data from large meta-analyses for genome-wide association studies in BPD do not show the GR as a very strong candidate.

SNPs reported by this study for BD (count: 224)

SNP	Related Gene(s)	Allele Change	Statistical Values	Author Comments	Result Category
rs10445368	MAPT-AS1 CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.2032, Odds Ratio=1.288	No significant association was observed. No significant association was observed.	Negative
rs10434128	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.1846, Odds Ratio=1.322	No significant association was observed. No significant association was observed.	Negative
rs10265589	GARS CRHR2	C/T	Single SNP analyses: Permuted P-value = 0.04359, Odds Ratio=0.7722	Significant associations were found . Significant associations were found .	Positive
rs10062367	CRHBP	A/G	Single SNP analyses: Permuted P-value = 0.6691, Odds Ratio=1.063	No significant association was observed. No significant association was observed.	Negative
rs10050229	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.5879, Odds Ratio=0.9269	No significant association was observed. No significant association was observed.	Negative
rs10041520	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.5617, Odds Ratio=0.9246	No significant association was observed. No significant association was observed.	Negative
rs10026568	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.2248, Odds Ratio=1.169	No significant association was observed. No significant association was observed.	Negative
rs10010766	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.1164, Odds Ratio=0.8294	No significant association was observed. No significant association was observed.	Negative
rs1049402	GARS CRHR2	C/G	Single SNP analyses: Permuted P-value = 0.009998, Odds Ratio=0.7109	Significant associations were found . Significant associations were found .	Positive
rs10482704	NR3C1	T/G	Single SNP analyses: Permuted P-value = 0.2294, Odds Ratio=1.586	No significant association was observed. No significant association was observed.	Negative
rs10482689	NR3C1	A/G	Single SNP analyses: Permuted P-value = 0.0009998, Odds Ratio=1.74	Significant associations were found . Significant associations were found .	Positive
rs10482682	NR3C1	A/G	Single SNP analyses: Permuted P-value = 0.0124, Odds Ratio=1.376	Significant associations were found . Significant associations were found .	Positive
rs10482672	NR3C1	T/C	Single SNP analyses: Permuted P-value = 0.1494, Odds Ratio=1.27	No significant association was observed. No significant association was observed.	Negative
rs10482668	NR3C1	T/A	Single SNP analyses: Permuted P-value = 0.1954, Odds Ratio=0.4209	No significant association was observed. No significant association was observed.	Negative
rs10482633	NR3C1	C/A	Single SNP analyses: Permuted P-value = 0.008798, Odds Ratio=1.641	Significant associations were found . Significant associations were found .	Positive
rs10482616	NR3C1	A/G	Single SNP analyses: Permuted P-value = 0.2036, Odds Ratio=1.317	No significant association was observed. No significant association was observed.	Negative
rs11099681	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.1464, Odds Ratio=1.213	No significant association was observed. No significant association was observed.	Negative
rs11099695	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.1506, Odds Ratio=0.833	No significant association was observed. No significant association was observed.	Negative
rs110402	CRHR1 MAPT-AS1	C/T	Single SNP analyses: Permuted P-value = 0.7493, Odds Ratio=0.9655	No significant association was observed. No significant association was observed.	Negative
rs11099678	NR3C2	T/A	Single SNP analyses: Permuted P-value = 0.4803, Odds Ratio=1.118	No significant association was observed. No significant association was observed.	Negative
rs1076292	CRHR2	C/G	Single SNP analyses: Permuted P-value = 0.3933, Odds Ratio=0.8979	No significant association was observed. No significant association was observed.	Negative
rs10951271	GARS CRHR2	C/A	Single SNP analyses: Permuted P-value = 0.7265, Odds Ratio=1.042	No significant association was observed. No significant association was observed.	Negative
rs10515522	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.5843, Odds Ratio=0.8755	No significant association was observed. No significant association was observed.	Negative
rs10519955	NR3C2	G/C	Single SNP analyses: Permuted P-value = 0.3837, Odds Ratio=0.6346	No significant association was observed. No significant association was observed.	Negative
rs11730626	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.4961, Odds Ratio=1.13	No significant association was observed. No significant association was observed.	Negative
rs11731398	NR3C2	G/T	Single SNP analyses: Permuted P-value = 0.6825, Odds Ratio=0.8221	No significant association was observed. No significant association was observed.	Negative
rs11725509	NR3C2	C/A	Single SNP analyses: Permuted P-value = 0.07319, Odds Ratio=0.3128	No significant association was observed. No significant association was observed.	Negative
rs11726964	NR3C2	A/C	Single SNP analyses: Permuted P-value = 0.1246, Odds Ratio=0.3124	No significant association was observed. No significant association was observed.	Negative
rs11657992	SPPL2C MAPT-AS1 CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.7279, Odds Ratio=0.9363	No significant association was observed. No significant association was observed.	Negative
rs11724292	NR3C2	C/A	Single SNP analyses: Permuted P-value = 0.9674, Odds Ratio=0.9932	No significant association was observed. No significant association was observed.	Negative
rs11553502	GARS CRHR2	C/T	Single SNP analyses: Permuted P-value = 0.4567, Odds Ratio=0.6098	No significant association was observed. No significant association was observed.	Negative
rs11652070	SPPL2C MAPT-AS1 CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.4325, Odds Ratio=1.149	No significant association was observed. No significant association was observed.	Negative
rs258750	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.9382, Odds Ratio=1.01	No significant association was observed. No significant association was observed.	Negative
rs2435212	MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.2332, Odds Ratio=0.8409	No significant association was observed. No significant association was observed.	Negative
rs2435207	MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.4239, Odds Ratio=0.9067	No significant association was observed. No significant association was observed.	Negative
rs2435206	MAPT CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.5119, Odds Ratio=0.9243	No significant association was observed. No significant association was observed.	Negative
rs2435205	MAPT CRHR1	G/A	Single SNP analyses: Permuted P-value = 0.1258, Odds Ratio=1.215	No significant association was observed. No significant association was observed.	Negative
rs242944	SPPL2C MAPT-AS1 CRHR1	C/T	Single SNP analyses: Permuted P-value = 0.3833, Odds Ratio=0.9023	No significant association was observed. No significant association was observed.	Negative
rs242943	SPPL2C MAPT-AS1 CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.6555, Odds Ratio=0.9032	No significant association was observed. No significant association was observed.	Negative
rs242562	MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.2835, Odds Ratio=0.8774	No significant association was observed. No significant association was observed.	Negative
rs242556	MAPT CRHR1	A/T	Single SNP analyses: Permuted P-value = 0.4309, Odds Ratio=1.11	No significant association was observed. No significant association was observed.	Negative
rs2356210	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.0234, Odds Ratio=0.7315	Significant associations were found . Significant associations were found .	Positive
rs2294807	FKBP5	T/C	Single SNP analyses: Permuted P-value = 0.8552, Odds Ratio=0.9594	No significant association was observed. No significant association was observed.	Negative
rs2293162	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.7746, Odds Ratio=1.326	No significant association was observed. No significant association was observed.	Negative
rs2284216	CRHR2	T/G	Single SNP analyses: Permuted P-value = 0.3343, Odds Ratio=0.7949	No significant association was observed. No significant association was observed.	Negative
rs2272089	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.22, Odds Ratio=1.202	No significant association was observed. No significant association was observed.	Negative
rs2267716	CRHR2	C/T	Single SNP analyses: Permuted P-value = 0.6247, Odds Ratio=0.9237	No significant association was observed. No significant association was observed.	Negative
rs2267715	CRHR2	G/A	Single SNP analyses: Permuted P-value = 0.3167, Odds Ratio=0.8837	No significant association was observed. No significant association was observed.	Negative
rs2258689	MAPT CRHR1	C/T	Single SNP analyses: Permuted P-value = 0.5527, Odds Ratio=0.9182	No significant association was observed. No significant association was observed.	Negative
rs2267712	CRHR2	A/C	Single SNP analyses: Permuted P-value = 0.1676, Odds Ratio=0.7798	No significant association was observed. No significant association was observed.	Negative
rs2190242	CRHR2	C/A	Single SNP analyses: Permuted P-value = 0.02559, Odds Ratio=0.7202	Significant associations were found . Significant associations were found .	Positive
rs2240403	CRHR2	T/C	Single SNP analyses: Permuted P-value = 0.2332, Odds Ratio=0.7974	No significant association was observed. No significant association was observed.	Negative
rs2137331	NR3C2	A/T	Single SNP analyses: Permuted P-value = 0.3545, Odds Ratio=1.118	No significant association was observed. No significant association was observed.	Negative
rs2143404	FKBP5	T/C	Single SNP analyses: Permuted P-value = 0.6047, Odds Ratio=1.094	No significant association was observed. No significant association was observed.	Negative
rs2135078	CRHBP	T/C	Single SNP analyses: Permuted P-value = 0.05659, Odds Ratio=1.26	No significant association was observed. No significant association was observed.	Negative
rs2137330	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.0242, Odds Ratio=1.752	Significant associations were found . Significant associations were found .	Positive
rs2063555	NR3C2	G/T	Single SNP analyses: Permuted P-value = 0.6403, Odds Ratio=1.11	No significant association was observed. No significant association was observed.	Negative
rs2121152	NR3C1	C/A	Single SNP analyses: Permuted P-value = 0.6423, Odds Ratio=0.9349	No significant association was observed. No significant association was observed.	Negative
rs2014663	CRHR2	G/A	Single SNP analyses: Permuted P-value = 0.1982, Odds Ratio=0.8191	No significant association was observed. No significant association was observed.	Negative
rs2055794	MAPT-AS1 CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.8552, Odds Ratio=1.041	No significant association was observed. No significant association was observed.	Negative
rs1994624	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.07598, Odds Ratio=0.8139	No significant association was observed. No significant association was observed.	Negative
rs1996025	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.4547, Odds Ratio=1.149	No significant association was observed. No significant association was observed.	Negative
rs1964691	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.07219, Odds Ratio=-	No significant association was observed. No significant association was observed.	Negative
rs1987969	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.8816, Odds Ratio=0.9772	No significant association was observed. No significant association was observed.	Negative
rs4513547	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.06279, Odds Ratio=0.7928	No significant association was observed. No significant association was observed.	Negative
rs4458044	CRHR1 MAPT-AS1	C/G	Single SNP analyses: Permuted P-value = 0.7123, Odds Ratio=0.9589	No significant association was observed. No significant association was observed.	Negative
rs4616318	SPPL2C MAPT-AS1 CRHR1	G/A	Single SNP analyses: Permuted P-value = 0.6243, Odds Ratio=1.062	No significant association was observed. No significant association was observed.	Negative
rs4607376	NR3C1	A/G	Single SNP analyses: Permuted P-value = 0.05759, Odds Ratio=1.239	No significant association was observed. No significant association was observed.	Negative
rs4128753	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.5407, Odds Ratio=1.083	No significant association was observed. No significant association was observed.	Negative
rs4027073	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.7331, Odds Ratio=0.9534	No significant association was observed. No significant association was observed.	Negative
rs4266550	CRHR2	G/A	Single SNP analyses: Permuted P-value = 0.4567, Odds Ratio=0.6098	No significant association was observed. No significant association was observed.	Negative
rs4260521	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.9378, Odds Ratio=1.012	No significant association was observed. No significant association was observed.	Negative
rs3857079	NR3C2	G/T	Single SNP analyses: Permuted P-value = 0.4501, Odds Ratio=1.096	No significant association was observed. No significant association was observed.	Negative
rs3846326	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.1304, Odds Ratio=0.8182	No significant association was observed. No significant association was observed.	Negative
rs3910057	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.6413, Odds Ratio=0.9174	No significant association was observed. No significant association was observed.	Negative
rs3857080	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.4923, Odds Ratio=1.172	No significant association was observed. No significant association was observed.	Negative
rs3846320	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.2789, Odds Ratio=0.8638	No significant association was observed. No significant association was observed.	Negative
rs3846317	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.4449, Odds Ratio=1.093	No significant association was observed. No significant association was observed.	Negative
rs3846322	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.05279, Odds Ratio=1.348	No significant association was observed. No significant association was observed.	Negative
rs3846321	NR3C2	A/C	Single SNP analyses: Permuted P-value = 0.236, Odds Ratio=1.174	No significant association was observed. No significant association was observed.	Negative
rs3843411	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.126, Odds Ratio=1.215	No significant association was observed. No significant association was observed.	Negative
rs3846300	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.6983, Odds Ratio=0.9486	No significant association was observed. No significant association was observed.	Negative
rs3846306	NR3C2	C/A	Single SNP analyses: Permuted P-value = 0.9032, Odds Ratio=0.9836	No significant association was observed. No significant association was observed.	Negative
rs3846313	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.8798, Odds Ratio=0.9729	No significant association was observed. No significant association was observed.	Negative
rs3785883	MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.1584, Odds Ratio=0.8175	No significant association was observed. No significant association was observed.	Negative
rs3785885	MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.6653, Odds Ratio=1.058	No significant association was observed. No significant association was observed.	Negative
rs3798346	FKBP5	G/A	Single SNP analyses: Permuted P-value = 0.3615, Odds Ratio=0.8876	No significant association was observed. No significant association was observed.	Negative
rs3800374	FKBP5	A/G	Single SNP analyses: Permuted P-value = 0.5553, Odds Ratio=0.8994	No significant association was observed. No significant association was observed.	Negative
rs33389	NR3C1	T/C	Single SNP analyses: Permuted P-value = 0.008598, Odds Ratio=0.665	Significant associations were found . Significant associations were found .	Positive
rs3777747	FKBP5	G/A	Single SNP analyses: Permuted P-value = 0.4221, Odds Ratio=1.098	No significant association was observed. No significant association was observed.	Negative
rs3785877	CRHR1 MAPT-AS1	A/G	Single SNP analyses: Permuted P-value = 0.855, Odds Ratio=0.9247	No significant association was observed. No significant association was observed.	Negative
rs3785880	MAPT CRHR1	T/G	Single SNP analyses: Permuted P-value = 0.3895, Odds Ratio=1.109	No significant association was observed. No significant association was observed.	Negative
rs2709772	GARS CRHR2	G/A	Single SNP analyses: Permuted P-value = 0.8798, Odds Ratio=1.047	No significant association was observed. No significant association was observed.	Negative
rs2709778	GARS CRHR2	T/C	Single SNP analyses: Permuted P-value = 0.3771, Odds Ratio=0.8478	No significant association was observed. No significant association was observed.	Negative
rs2709809	GARS CRHR2	C/A	Single SNP analyses: Permuted P-value = 0.1688, Odds Ratio=0.8237	No significant association was observed. No significant association was observed.	Negative
rs2963155	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.04559, Odds Ratio=0.75	Significant associations were found . Significant associations were found .	Positive
rs17024631	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.1804, Odds Ratio=0.648	No significant association was observed. No significant association was observed.	Negative
rs17024506	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.8872, Odds Ratio=1.063	No significant association was observed. No significant association was observed.	Negative
rs17024482	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.5813, Odds Ratio=0.8382	No significant association was observed. No significant association was observed.	Negative
rs17024456	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.5307, Odds Ratio=0.9017	No significant association was observed. No significant association was observed.	Negative
rs17100306	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.6583, Odds Ratio=1.145	No significant association was observed. No significant association was observed.	Negative
rs17100289	NR3C1	T/A	Single SNP analyses: Permuted P-value = 0.1402, Odds Ratio=0.8335	No significant association was observed. No significant association was observed.	Negative
rs17100236	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.3145, Odds Ratio=1.25	No significant association was observed. No significant association was observed.	Negative
rs17024654	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.183, Odds Ratio=0.6586	No significant association was observed. No significant association was observed.	Negative
rs1560310	MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.1684, Odds Ratio=1.268	No significant association was observed. No significant association was observed.	Negative
rs1512343	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.17, Odds Ratio=0.8379	No significant association was observed. No significant association was observed.	Negative
rs1467967	MAPT CRHR1	G/A	Single SNP analyses: Permuted P-value = 0.5109, Odds Ratio=1.104	No significant association was observed. No significant association was observed.	Negative
rs1403143	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.4905, Odds Ratio=1.083	No significant association was observed. No significant association was observed.	Negative
rs17024443	NR3C2	C/G	Single SNP analyses: Permuted P-value = 0.213, Odds Ratio=1.311	No significant association was observed. No significant association was observed.	Negative
rs17024404	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.6219, Odds Ratio=1.097	No significant association was observed. No significant association was observed.	Negative
rs1700687	CRHBP	G/A	Single SNP analyses: Permuted P-value = 0.09018, Odds Ratio=1.218	No significant association was observed. No significant association was observed.	Negative
rs1700679	CRHBP	A/G	Single SNP analyses: Permuted P-value = 0.5287, Odds Ratio=1.077	No significant association was observed. No significant association was observed.	Negative
rs13133379	NR3C2	T/G	Single SNP analyses: Permuted P-value = 0.837, Odds Ratio=0.9657	No significant association was observed. No significant association was observed.	Negative
rs13137823	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.6565, Odds Ratio=0.9332	No significant association was observed. No significant association was observed.	Negative
rs13116099	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.2673, Odds Ratio=1.146	No significant association was observed. No significant association was observed.	Negative
rs13116347	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.3155, Odds Ratio=1.17	No significant association was observed. No significant association was observed.	Negative
rs1334894	FKBP5	T/C	Single SNP analyses: Permuted P-value = 0.8442, Odds Ratio=1.041	No significant association was observed. No significant association was observed.	Negative
rs1360780	FKBP5	T/C	Single SNP analyses: Permuted P-value = 0.8218, Odds Ratio=1.034	No significant association was observed. No significant association was observed.	Negative
rs13142954	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.05959, Odds Ratio=0.7726	No significant association was observed. No significant association was observed.	Negative
rs13192954	FKBP5 MIR5690	G/A	Single SNP analyses: Permuted P-value = 0.6981, Odds Ratio=0.8841	No significant association was observed. No significant association was observed.	Negative
rs11979352	GARS CRHR2	A/G	Single SNP analyses: Permuted P-value = 0.771, Odds Ratio=0.8879	No significant association was observed. No significant association was observed.	Negative
rs12150516	MAPT-AS1 CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.9568, Odds Ratio=1.009	No significant association was observed. No significant association was observed.	Negative
rs11945778	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.871, Odds Ratio=0.9791	No significant association was observed. No significant association was observed.	Negative
rs11950140	RNU6ATAC36P CRHBP	G/C	Single SNP analyses: Permuted P-value = 0.6875, Odds Ratio=0.888	No significant association was observed. No significant association was observed.	Negative
rs12711259	NR3C2	T/G	Single SNP analyses: Permuted P-value = 0.05579, Odds Ratio=0.7807	No significant association was observed. No significant association was observed.	Negative
rs13109933	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.2575, Odds Ratio=1.144	No significant association was observed. No significant association was observed.	Negative
rs12511893	NR3C2	A/T	Single SNP analyses: Permuted P-value = 0.9334, Odds Ratio=0.9849	No significant association was observed. No significant association was observed.	Negative
rs12512126	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.5843, Odds Ratio=1.071	No significant association was observed. No significant association was observed.	Negative
rs17763658	SPPL2C MAPT-AS1 CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.1354, Odds Ratio=0.7177	No significant association was observed. No significant association was observed.	Negative
rs17762769	CRHR1 MAPT-AS1	A/G	Single SNP analyses: Permuted P-value = 0.8396, Odds Ratio=1.037	No significant association was observed. No significant association was observed.	Negative
rs1866388	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.9352, Odds Ratio=0.9888	No significant association was observed. No significant association was observed.	Negative
rs1864325	MAPT MAPT-AS1 CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.5153, Odds Ratio=1.145	No significant association was observed. No significant association was observed.	Negative
rs1875999	CRHBP	G/A	Single SNP analyses: Permuted P-value = 0.07978, Odds Ratio=1.243	No significant association was observed. No significant association was observed.	Negative
rs1873174	ARHGAP10 NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.4395, Odds Ratio=0.905	No significant association was observed. No significant association was observed.	Negative
rs1879828	NR3C2	A/T	Single SNP analyses: Permuted P-value = 0.6155, Odds Ratio=1.065	No significant association was observed. No significant association was observed.	Negative
rs1879827	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.2585, Odds Ratio=0.8471	No significant association was observed. No significant association was observed.	Negative
rs17563986	MAPT CRHR1	G/A	Single SNP analyses: Permuted P-value = 0.3759, Odds Ratio=1.162	No significant association was observed. No significant association was observed.	Negative
rs17542466	FKBP5	G/A	Single SNP analyses: Permuted P-value = 0.2424, Odds Ratio=0.8639	No significant association was observed. No significant association was observed.	Negative
rs17581311	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.6649, Odds Ratio=1.051	No significant association was observed. No significant association was observed.	Negative
rs17580954	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.4613, Odds Ratio=0.8205	No significant association was observed. No significant association was observed.	Negative
rs17620330	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.1432, Odds Ratio=1.345	No significant association was observed. No significant association was observed.	Negative
rs17614642	FKBP5	C/T	Single SNP analyses: Permuted P-value = 0.4799, Odds Ratio=0.8612	No significant association was observed. No significant association was observed.	Negative
rs17690703	SPPL2C MAPT-AS1 CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.3723, Odds Ratio=1.151	No significant association was observed. No significant association was observed.	Negative
rs17670187	RNU6ATAC36P CRHBP	C/G	Single SNP analyses: Permuted P-value = 0.3199, Odds Ratio=1.273	No significant association was observed. No significant association was observed.	Negative
rs17484063	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.2046, Odds Ratio=0.8372	No significant association was observed. No significant association was observed.	Negative
rs17484118	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.116, Odds Ratio=0.8098	No significant association was observed. No significant association was observed.	Negative
rs17484245	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.0234, Odds Ratio=1.906	Significant associations were found . Significant associations were found .	Positive
rs17484259	NR3C2	A/C	Single SNP analyses: Permuted P-value = 0.1456, Odds Ratio=0.8162	No significant association was observed. No significant association was observed.	Negative
rs17484357	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.8612, Odds Ratio=1.028	No significant association was observed. No significant association was observed.	Negative
rs17484671	NR3C2	T/G	Single SNP analyses: Permuted P-value = 0.127, Odds Ratio=0.8257	No significant association was observed. No significant association was observed.	Negative
rs17484811	NR3C2	C/A	Single SNP analyses: Permuted P-value = 0.7019, Odds Ratio=1.068	No significant association was observed. No significant association was observed.	Negative
rs17484839	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.9056, Odds Ratio=1.028	No significant association was observed. No significant association was observed.	Negative
rs171443	SPPL2C MAPT-AS1 CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.2312, Odds Ratio=0.7506	No significant association was observed. No significant association was observed.	Negative
rs17159289	GARS CRHR2	C/A	Single SNP analyses: Permuted P-value = 0.2464, Odds Ratio=0.5928	No significant association was observed. No significant association was observed.	Negative
rs17209237	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.5003, Odds Ratio=1.098	No significant association was observed. No significant association was observed.	Negative
rs17209258	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.6947, Odds Ratio=1.06	No significant association was observed. No significant association was observed.	Negative
rs17399352	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.809, Odds Ratio=1.04	No significant association was observed. No significant association was observed.	Negative
rs17483391	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.7427, Odds Ratio=0.9431	No significant association was observed. No significant association was observed.	Negative
rs17483687	NR3C2	C/A	Single SNP analyses: Permuted P-value = 0.761, Odds Ratio=1.075	No significant association was observed. No significant association was observed.	Negative
rs17483979	NR3C2	C/A	Single SNP analyses: Permuted P-value = 0.4929, Odds Ratio=1.102	No significant association was observed. No significant association was observed.	Negative
rs6812904	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.9048, Odds Ratio=1.013	No significant association was observed. No significant association was observed.	Negative
rs6815984	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.02819, Odds Ratio=1.306	Significant associations were found . Significant associations were found .	Positive
rs6535594	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.866, Odds Ratio=0.9783	No significant association was observed. No significant association was observed.	Negative
rs6810951	NR3C2	T/G	Single SNP analyses: Permuted P-value = 0.03359, Odds Ratio=0.7737	Significant associations were found . Significant associations were found .	Positive
rs6849127	NR3C2	T/A	Single SNP analyses: Permuted P-value = 0.6367, Odds Ratio=1.07	No significant association was observed. No significant association was observed.	Negative
rs6849903	NR3C2	G/T	Single SNP analyses: Permuted P-value = 0.04699, Odds Ratio=0.7711	Significant associations were found . Significant associations were found .	Positive
rs6823323	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.957, Odds Ratio=0.9921	No significant association was observed. No significant association was observed.	Negative
rs6844155	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.1304, Odds Ratio=1.222	No significant association was observed. No significant association was observed.	Negative
rs6912833	FKBP5	A/T	Single SNP analyses: Permuted P-value = 0.8034, Odds Ratio=1.033	No significant association was observed. No significant association was observed.	Negative
rs7210728	MAPT MAPT-AS1 CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.2937, Odds Ratio=1.147	No significant association was observed. No significant association was observed.	Negative
rs6857487	NR3C2	A/T	Single SNP analyses: Permuted P-value = 0.3039, Odds Ratio=0.8764	No significant association was observed. No significant association was observed.	Negative
rs6877893	NR3C1	A/G	Single SNP analyses: Permuted P-value = 0.8922, Odds Ratio=1.02	No significant association was observed. No significant association was observed.	Negative
rs737054	FKBP5	T/C	Single SNP analyses: Permuted P-value = 0.6181, Odds Ratio=1.068	No significant association was observed. No significant association was observed.	Negative
rs754593	MAPT CRHR1	G/A	Single SNP analyses: Permuted P-value = 0.7057, Odds Ratio=0.9558	No significant association was observed. No significant association was observed.	Negative
rs7220988	KANSL1 MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.5945, Odds Ratio=1.071	No significant association was observed. No significant association was observed.	Negative
rs7224541	MAPT MAPT-AS1 CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.8634, Odds Ratio=1.029	No significant association was observed. No significant association was observed.	Negative
rs4792825	SPPL2C MAPT-AS1 CRHR1	G/A	Single SNP analyses: Permuted P-value = 0.2729, Odds Ratio=0.7936	No significant association was observed. No significant association was observed.	Negative
rs4723000	CRHR2	A/G	Single SNP analyses: Permuted P-value = 0.78, Odds Ratio=0.948	No significant association was observed. No significant association was observed.	Negative
rs4713902	FKBP5	C/T	Single SNP analyses: Permuted P-value = 0.5859, Odds Ratio=1.075	No significant association was observed. No significant association was observed.	Negative
rs4713899	FKBP5	A/G	Single SNP analyses: Permuted P-value = 0.4845, Odds Ratio=1.11	No significant association was observed. No significant association was observed.	Negative
rs4792897	MAPT CRHR1	G/A	Single SNP analyses: Permuted P-value = 0.7662, Odds Ratio=0.9502	No significant association was observed. No significant association was observed.	Negative
rs4792894	MAPT CRHR1	A/G	Single SNP analyses: Permuted P-value = 0.4099, Odds Ratio=0.8558	No significant association was observed. No significant association was observed.	Negative
rs4792891	MAPT MAPT-AS1 CRHR1	G/T	Single SNP analyses: Permuted P-value = 0.3059, Odds Ratio=1.14	No significant association was observed. No significant association was observed.	Negative
rs4792887	CRHR1 MAPT-AS1	T/C	Single SNP analyses: Permuted P-value = 0.4973, Odds Ratio=0.8741	No significant association was observed. No significant association was observed.	Negative
rs4912911	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.2424, Odds Ratio=0.8591	No significant association was observed. No significant association was observed.	Negative
rs4835494	NR3C2	C/G	Single SNP analyses: Permuted P-value = 0.06999, Odds Ratio=1.54	No significant association was observed. No significant association was observed.	Negative
rs4835491	NR3C2	C/G	Single SNP analyses: Permuted P-value = 0.1082, Odds Ratio=1.228	No significant association was observed. No significant association was observed.	Negative
rs4835490	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.8092, Odds Ratio=1.046	No significant association was observed. No significant association was observed.	Negative
rs6535584	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.1948, Odds Ratio=1.185	No significant association was observed. No significant association was observed.	Negative
rs6535583	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.8726, Odds Ratio=0.9758	No significant association was observed. No significant association was observed.	Negative
rs6196	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.02939, Odds Ratio=0.7022	Significant associations were found . Significant associations were found .	Positive
rs5534	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.215, Odds Ratio=0.8604	No significant association was observed. No significant association was observed.	Negative
rs8079215	MAPT CRHR1	C/T	Single SNP analyses: Permuted P-value = 0.3863, Odds Ratio=1.121	No significant association was observed. No significant association was observed.	Negative
rs907620	NR3C2	G/A	Single SNP analyses: Permuted P-value = 0.0168, Odds Ratio=0.729	Significant associations were found . Significant associations were found .	Positive
rs907621	NR3C2	A/G	Single SNP analyses: Permuted P-value = 0.07838, Odds Ratio=0.7493	No significant association was observed. No significant association was observed.	Negative
rs9296157	FKBP5	C/G	Single SNP analyses: Permuted P-value = 0.5111, Odds Ratio=0.8978	No significant association was observed. No significant association was observed.	Negative
rs9296158	FKBP5	A/G	Single SNP analyses: Permuted P-value = 0.9192, Odds Ratio=1.014	No significant association was observed. No significant association was observed.	Negative
rs9324918	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.0168, Odds Ratio=0.6968	Significant associations were found . Significant associations were found .	Positive
rs9324921	NR3C1	A/C	Single SNP analyses: Permuted P-value = 0.2024, Odds Ratio=0.7279	No significant association was observed. No significant association was observed.	Negative
rs9324924	NR3C1	T/G	Single SNP analyses: Permuted P-value = 0.03619, Odds Ratio=0.7796	Significant associations were found . Significant associations were found .	Positive
rs9366890	FKBP5	T/A	Single SNP analyses: Permuted P-value = 0.8262, Odds Ratio=1.035	No significant association was observed. No significant association was observed.	Negative
rs9380524	FKBP5	A/C	Single SNP analyses: Permuted P-value = 0.3469, Odds Ratio=0.7934	No significant association was observed. No significant association was observed.	Negative
rs9470080	FKBP5	T/C	Single SNP analyses: Permuted P-value = 0.6635, Odds Ratio=1.054	No significant association was observed. No significant association was observed.	Negative
rs973002	CRHR2	G/A	Single SNP analyses: Permuted P-value = 0.1264, Odds Ratio=0.7976	No significant association was observed. No significant association was observed.	Negative
rs982076	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.8926, Odds Ratio=0.9819	No significant association was observed. No significant association was observed.	Negative
rs9896752	MAPT-AS1 CRHR1	C/T	Single SNP analyses: Permuted P-value = 0.1442, Odds Ratio=0.7368	No significant association was observed. No significant association was observed.	Negative
rs9913462	MAPT CRHR1	C/G	Single SNP analyses: Permuted P-value = 0.9814, Odds Ratio=1.001	No significant association was observed. No significant association was observed.	Negative
rs992105	FKBP5	C/A	Single SNP analyses: Permuted P-value = 0.6945, Odds Ratio=0.9412	No significant association was observed. No significant association was observed.	Negative
rs7661326	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.3677, Odds Ratio=0.7114	No significant association was observed. No significant association was observed.	Negative
rs755658	FKBP5	A/G	Single SNP analyses: Permuted P-value = 0.9876, Odds Ratio=1.013	No significant association was observed. No significant association was observed.	Negative
rs7691663	NR3C2	C/A	Single SNP analyses: Permuted P-value = 0.1168, Odds Ratio=0.8351	No significant association was observed. No significant association was observed.	Negative
rs7680420	NR3C2	C/T	Single SNP analyses: Permuted P-value = 0.3223, Odds Ratio=0.83	No significant association was observed. No significant association was observed.	Negative
rs7701443	NR3C1	G/A	Single SNP analyses: Permuted P-value = 0.3747, Odds Ratio=0.8887	No significant association was observed. No significant association was observed.	Negative
rs7699349	NR3C2	T/C	Single SNP analyses: Permuted P-value = 0.4145, Odds Ratio=0.8966	No significant association was observed. No significant association was observed.	Negative
rs7709864	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.799, Odds Ratio=0.8929	No significant association was observed. No significant association was observed.	Negative
rs7705497	NR3C1	A/T	Single SNP analyses: Permuted P-value = 0.7508, Odds Ratio=0.9611	No significant association was observed. No significant association was observed.	Negative
rs7718461	CRHBP	G/A	Single SNP analyses: Permuted P-value = 0.2048, Odds Ratio=1.165	No significant association was observed. No significant association was observed.	Negative
rs7714402	NR3C1	C/T	Single SNP analyses: Permuted P-value = 0.8388, Odds Ratio=0.9747	No significant association was observed. No significant association was observed.	Negative
rs7728378	CRHBP	C/T	Single SNP analyses: Permuted P-value = 0.151, Odds Ratio=1.189	No significant association was observed. No significant association was observed.	Negative
rs7720743	NR3C1	T/A	Single SNP analyses: Permuted P-value = 0.2579, Odds Ratio=1.145	No significant association was observed. No significant association was observed.	Negative
rs7757037	FKBP5	A/G	Single SNP analyses: Permuted P-value = 0.2244, Odds Ratio=1.153	No significant association was observed. No significant association was observed.	Negative
rs7728928	NR3C1	T/C	Single SNP analyses: Permuted P-value = 0.5279, Odds Ratio=0.9247	No significant association was observed. No significant association was observed.	Negative
rs8078967	MAPT CRHR1	T/C	Single SNP analyses: Permuted P-value = 0.7007, Odds Ratio=0.9557	No significant association was observed. No significant association was observed.	Negative
rs8064870	SPPL2C MAPT-AS1 CRHR1	C/T	Single SNP analyses: Permuted P-value = 0.796, Odds Ratio=1.034	No significant association was observed. No significant association was observed.	Negative

Other variants reported by this study for BD (count: 1)

Variant Name	Related Gene	Type	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs6195	NR3C1	point mutation	G/A		Single SNP analyses:Permuted P-value = 0.2214, Odds Ratio=1.48	No significant association was observed. No significant association was observed.	Negative

Genes reported by this study for BD (count: 6)

Gene	Statistical Values/Author Comments	Result Category
NR3C1	This study contributes to the growing evidence for a role of the glucocorticoid receptor gene (NR3C1...... This study contributes to the growing evidence for a role of the glucocorticoid receptor gene (NR3C1) in vulnerability to mood disorders, and BPD in particular, and warrants further in vitro investigation of the at-risk haplotypes with respect to disease etiology. More...	Positive
CRHR2	Significant associations were detected in BD patients. Significant associations were detected in BD patients.	Positive
NR3C2	Significant associations were detected in BD patients. Significant associations were detected in BD patients.	Positive
CRHBP	No significant associations were detected in BD patients. No significant associations were detected in BD patients.	Negative
CRHR1	No significant associations were detected in BD patients. No significant associations were detected in BD patients.	Negative
FKBP5	No significant associations were detected in BD patients. No significant associations were detected in BD patients.	Negative