SNP Report

Basic Info

Name	rs7224541 dbSNP Ensembl
Location	chrCHR_HSCHR17_2_CTG5:45908853 - 45908853(1)
Variant Alleles	A/G
Ancestral Allele	G
Minor Allele	A
Minor Allele Frequence	0.116214
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000262410, ENST00000334239, ENST00000340799, ENST00000344290, ENST00000351559, ENST00000446361, ENST00000535772, ENST00000570299, ENST00000571311); NMD_transcript_variant(ENST00000571311); non_coding_transcript_exon_variant(ENST00000624111); non_coding_transcript_variant(ENST00000570299, ENST00000624111); upstream_gene_variant(ENST00000579244, ENST00000579599, ENST00000634876, ENST00000625688, ENST00000626571, ENST00000627067, ENST00000628393, ENST00000625688, ENST00000626958, ENST00000626958, ENST00000627067, ENST00000628274, ENST00000629948, ENST00000612872, ENST00000618029, ENST00000618825, ENST00000620070, ENST00000620818, ENST00000622106, ENST00000632975, ENST00000633047, ENST00000633415, ENST00000633415, ENST00000633806, ENST00000632975, ENST00000633806, ENST00000632082, ENST00000633517)
No. of Studies	1 (Positive: 0; Negative: 1; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ceulemans, S.,2011	A/G		Single SNP analyses: Permuted P-value = 0.8634, Odds Ratio=1...... Single SNP analyses: Permuted P-value = 0.8634, Odds Ratio=1.029 More...	No significant association was observed. No significant association was observed.	Negative

SNP related genes (count: 3)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
MAPT-AS1	MAPT antisense RNA 1	17q21.31	Mapped by Literature SNP
MAPT	microtubule-associated protein tau	17q21	Mapped by Literature SNP
CRHR1	corticotropin releasing hormone receptor 1	17q21.31	4(2/2/0)

SNPs in LD with rs7224541 (count: 1) View in gBrowse (chrCHR_HSCHR17_2_CTG5:45908853..45919961 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Literature-origin SNPs with LD	Functional Annotation	r²[population]
rs4792893		intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	0.954[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)