SNP Report

Basic Info

Name	rs10265589 dbSNP Ensembl
Location	chr7:30595984 - 30595984(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.40016
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000627489); intron_variant(ENST00000389266, ENST00000454308, ENST00000478124, LRG_243t1); NMD_transcript_variant(ENST00000454308); non_coding_transcript_variant(ENST00000478124); upstream_gene_variant(ENST00000426529, ENST00000578994, ENST00000579174, ENST00000580440, ENST00000581665, ENST00000581794, ENST00000582549, ENST00000582733, ENST00000583664, ENST00000584199, ENST00000584372)
No. of Studies	1 (Positive: 1; Negative: 0; Trend: 0)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ceulemans, S.,2011	C/T		Single SNP analyses: Permuted P-value = 0.04359, Odds Ratio=...... Single SNP analyses: Permuted P-value = 0.04359, Odds Ratio=0.7722 More...	Significant associations were found . Significant associations were found .	Positive

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
CRHR2	corticotropin releasing hormone receptor 2	7p14.3	3(2/1/0)
GARS	glycyl-tRNA synthetase	7p15	Mapped by Literature SNP

SNPs in LD with rs10265589 (count: 20) View in gBrowse (chr7:30501416..30656574 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 20)

rs_ID	Functional Annotation	r²[population]
rs6462211	intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.901[CEU]
rs10239660	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1.0[CEU]
rs12532057	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]
rs12533961	downstream_gene_variant; intron_variant; non_coding_transcript_variant; splice_donor_variant; upstream_gene_variant	1.0[CEU]
rs2009662	downstream_gene_variant	0.956[CEU]
rs10249885	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant	1.0[CEU]
rs6970807	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]
rs2270025	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]
rs1558064	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0[CEU]
rs4722999	intron_variant; NMD_transcript_variant	0.825[CEU]
rs2240401	downstream_gene_variant; intron_variant; non_coding_transcript_variant; splice_region_variant	1.0[CEU]
rs2267710	intron_variant; NMD_transcript_variant	0.825[CEU]
rs9648369	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]
rs10227133	intron_variant; non_coding_transcript_variant; upstream_gene_variant	1.0[CEU]
rs3779250	intron_variant; NMD_transcript_variant	0.915[CEU]
rs10237725	downstream_gene_variant; intron_variant; non_coding_transcript_variant	0.839[CEU]
rs1468402	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	0.955[CEU]
rs2391870	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.817[CEU]
rs3807632	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0[CEU]
rs11761080	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)