KEGG Pathway Report

Basic Info
ID hsa04020
Name Calcium signaling pathway
No. of Genes in BDgene  53
Source Pathway by PBA

PBA Result
Pathway Name in Paper Source Reference Data Set Tool Result Parameters Result Link
Calcium signaling pathway i-GSEA analysis From NIMH Trinity College Dublin i-GSEA by using i-GSEA4GWAS P-value< 0.001, FDR=0.0055 Link in i-GSEA4GWAS

Pathway related genes in BDgene (count: 53)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
EGFR epidermal growth factor receptor 7p12 1(0/0/1)
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1q32 1(0/1/0)
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 12q24.11 2(0/2/0)
NOS1 nitric oxide synthase 1 (neuronal) 12q24.22 8(2/5/1)
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 9q34 1(1/0/0)
ADCY2 adenylate cyclase 2 (brain) 5p15.3 2(1/1/0)
ADRA1B adrenoceptor alpha 1B 5q33.3 1(1/0/0)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 12q24.32 1(0/1/0)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16q24.1 1(0/1/0)
ADRA1A adrenoceptor alpha 1A 8p21.2 2(0/2/0)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 2(0/2/0)
PTGFR prostaglandin F receptor (FP) 1p31.1 1(1/0/0)
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 7q36.1 2(1/1/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 7(4/3/0)
CCKBR cholecystokinin B receptor 11p15.4 1(1/0/0)
PLCG1 phospholipase C, gamma 1 20q12-q13.1 1(0/1/0)
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3p14.3 1(1/0/0)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 15q13.3 4(2/2/0)
ADRB2 adrenoceptor beta 2, surface 5q31-q32 1(1/0/0)
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1q25.3 1(1/0/0)
ADCY9 adenylate cyclase 9 16p13.3 2(1/1/0)
BDKRB1 bradykinin receptor B1 14q32.1-q32.2 1(1/0/0)
CHRM5 cholinergic receptor, muscarinic 5 15q26 1(0/1/0)
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 10q22.2 2(1/1/0)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 5q32 2(1/1/0)
ADCY8 adenylate cyclase 8 (brain) 8q24 4(2/1/1)
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 3(1/2/0)
DRD5 dopamine receptor D5 4p16.1 2(0/2/0)
ERBB4 erb-b2 receptor tyrosine kinase 4 2q33.3-q34 2(1/1/0)
DRD1 dopamine receptor D1 5q34-q35 11(6/5/0)
CHRM2 cholinergic receptor, muscarinic 2 7q35-q36 1(0/1/0)
OXTR oxytocin receptor 3p25 1(0/1/0)
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5q31-q33 2(1/1/0)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 1(1/0/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 22(7/15/0)
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 12q24 9(2/7/0)
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 8p21.3 1(0/1/0)
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 9q34.3 3(2/1/0)
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 19q13.33 1(1/0/0)
TACR1 tachykinin receptor 1 2p13.1-p12 3(3/0/0)
CHRM1 cholinergic receptor, muscarinic 1 11q12-q13 1(0/1/0)
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1p36.1 1(0/1/0)
AGTR1 angiotensin II receptor, type 1 3q24 1(1/0/0)
CHRM3 cholinergic receptor, muscarinic 3 1q43 1(0/1/0)
RYR2 ryanodine receptor 2 (cardiac) 1q43 1(1/0/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 20(17/3/0)
NOS3 nitric oxide synthase 3 (endothelial cell) 7q36 2(1/1/0)
GNAS GNAS complex locus 20q13.2-q13.3 1(0/1/0)
TRHR thyrotropin-releasing hormone receptor 8q23.1 1(0/1/0)
AVPR1B arginine vasopressin receptor 1B 1q32 4(3/1/0)
BDKRB2 bradykinin receptor B2 14q32.1-q32.2 1(1/0/0)
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10q21-q24 2(0/2/0)
ADORA2B adenosine A2b receptor 17p12 1(1/0/0)