KEGG Pathway Report

Basic Info

ID	hsa04020
Name	Calcium signaling pathway
No. of Genes in BDgene	53
Source	Pathway by PBA

PBA Result

Pathway Name in Paper	Source	Reference	Data Set	Tool	Result Parameters	Result Link
Calcium signaling pathway	i-GSEA analysis	From NIMH	Trinity College Dublin	i-GSEA by using i-GSEA4GWAS	P-value< 0.001, FDR=0.0055	Link in i-GSEA4GWAS

Pathway related genes in BDgene (count: 53)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
EGFR	epidermal growth factor receptor	7p12	1(0/0/1)
CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit	1q32	1(0/1/0)
ATP2A2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	12q24.11	2(0/2/0)
NOS1	nitric oxide synthase 1 (neuronal)	12q24.22	8(2/5/1)
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	9q34	1(1/0/0)
ADCY2	adenylate cyclase 2 (brain)	5p15.3	2(1/1/0)
ADRA1B	adrenoceptor alpha 1B	5q33.3	1(1/0/0)
P2RX4	purinergic receptor P2X, ligand gated ion channel, 4	12q24.32	1(0/1/0)
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	16q24.1	1(0/1/0)
ADRA1A	adrenoceptor alpha 1A	8p21.2	2(0/2/0)
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	2(0/2/0)
PTGFR	prostaglandin F receptor (FP)	1p31.1	1(1/0/0)
HTR5A	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	7q36.1	2(1/1/0)
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Xq23	7(4/3/0)
CCKBR	cholecystokinin B receptor	11p15.4	1(1/0/0)
PLCG1	phospholipase C, gamma 1	20q12-q13.1	1(0/1/0)
CACNA1D	calcium channel, voltage-dependent, L type, alpha 1D subunit	3p14.3	1(1/0/0)
CHRNA7	cholinergic receptor, nicotinic, alpha 7 (neuronal)	15q13.3	4(2/2/0)
ADRB2	adrenoceptor beta 2, surface	5q31-q32	1(1/0/0)
CACNA1E	calcium channel, voltage-dependent, R type, alpha 1E subunit	1q25.3	1(1/0/0)
ADCY9	adenylate cyclase 9	16p13.3	2(1/1/0)
BDKRB1	bradykinin receptor B1	14q32.1-q32.2	1(1/0/0)
CHRM5	cholinergic receptor, muscarinic 5	15q26	1(0/1/0)
PPP3CB	protein phosphatase 3, catalytic subunit, beta isozyme	10q22.2	2(1/1/0)
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	5q32	2(1/1/0)
ADCY8	adenylate cyclase 8 (brain)	8q24	4(2/1/1)
HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	1p36-p35	3(1/2/0)
DRD5	dopamine receptor D5	4p16.1	2(0/2/0)
ERBB4	erb-b2 receptor tyrosine kinase 4	2q33.3-q34	2(1/1/0)
DRD1	dopamine receptor D1	5q34-q35	11(6/5/0)
CHRM2	cholinergic receptor, muscarinic 2	7q35-q36	1(0/1/0)
OXTR	oxytocin receptor	3p25	1(0/1/0)
HTR4	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	5q31-q33	2(1/1/0)
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	16p13.2	1(1/0/0)
HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	13q14-q21	22(7/15/0)
P2RX7	purinergic receptor P2X, ligand gated ion channel, 7	12q24	9(2/7/0)
PPP3CC	protein phosphatase 3, catalytic subunit, gamma isozyme	8p21.3	1(0/1/0)
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	9q34.3	3(2/1/0)
GRIN2D	glutamate receptor, ionotropic, N-methyl D-aspartate 2D	19q13.33	1(1/0/0)
TACR1	tachykinin receptor 1	2p13.1-p12	3(3/0/0)
CHRM1	cholinergic receptor, muscarinic 1	11q12-q13	1(0/1/0)
PRKACB	protein kinase, cAMP-dependent, catalytic, beta	1p36.1	1(0/1/0)
AGTR1	angiotensin II receptor, type 1	3q24	1(1/0/0)
CHRM3	cholinergic receptor, muscarinic 3	1q43	1(0/1/0)
RYR2	ryanodine receptor 2 (cardiac)	1q43	1(1/0/0)
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	12p13.3	20(17/3/0)
NOS3	nitric oxide synthase 3 (endothelial cell)	7q36	2(1/1/0)
GNAS	GNAS complex locus	20q13.2-q13.3	1(0/1/0)
TRHR	thyrotropin-releasing hormone receptor	8q23.1	1(0/1/0)
AVPR1B	arginine vasopressin receptor 1B	1q32	4(3/1/0)
BDKRB2	bradykinin receptor B2	14q32.1-q32.2	1(1/0/0)
HTR7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	10q21-q24	2(0/2/0)
ADORA2B	adenosine A2b receptor	17p12	1(1/0/0)