BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

Search Gene with Disease Search Gene1 with Disease

Meta-analysis Report

Comment on Study

View All Comments on Study

Basic Info

Reference	Chen, D. T.,2011 PMID: 22182935
Citation	Chen, D. T., X. Jiang, et al. (2011). "Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder." Mol Psychiatry.
Disease Type	Bipolar Disorder
Study Type	Genome-wide association study

Detail Info

SNPs reported by this study for BD (count: 12)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs17023019	CADM2		A	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 8.37E-08, Random effects P-value = 3.63E-07, I²=63.83, Q test=8.29, Q test P-value = 0.04	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs17138171	TENM4		C	Meta-analysis results by ancestry: European-ancestry phase I and phase II samples: Fixed effects P-value = 6.36E-07, Random effects P-value = 1.28E-07, I²=0, Q test=1.89, Q test P-value = 0.755	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs2251219	PBRM1 SMIM4 RNU6-856P		T	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 6.35E-07, Random effects P-value = 5.63E-07, I²=0, Q test=2.82, Q test P-value = 0.421; European and Asian-ancestry phase I & phase II samples: Fixed effects P-value = 1.84E-07, Random effects P-value = 1.63E-07, I²=32.9, Q test=7.45, Q test P-value = 0.189; European-ancestry phase I samples: Fixed effects P-value = 2.81E-07, Random effects P-value = 2.36E-07, I²=0, Q test=0.69, Q test P-value = 0.708; European-ancestry phase I and phase II samples: Fixed effects P-value = 1.03E-07, Random effects P-value = 8.39E-08, I²=29.5, Q test=5.67, Q test P-value = 0.225	The results suggest novel association findings. The results suggest novel association findings.	Positive
rs2271893	LMAN2L		G	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 1.08E-08, Random effects P-value = 5.20EC10, I²=43.83, Q test=5.34, Q test P-value = 0.148; European and Asian-ancestry phase I & phase II samples: Fixed effects P-value = 5.21E-09, Random effects P-value = 2.20EC10, I²=52.31, Q test=10.49, Q test P-value = 0.063; European-ancestry phase I samples: Fixed effects P-value = 1.21E-09, Random effects P-value = 1.73EC10, I²=16.16, Q test=2.39, Q test P-value = 0.303; European-ancestry phase I and phase II samples: Fixed effects P-value = 9.81EC10, Random effects P-value = 1.34EC10, I²=51.27, Q test=8.21, Q test P-value = 0.084	The results suggest novel association findings. The results suggest novel association findings.	Positive
rs2875907	CADM2		A	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 7.44E-08, Random effects P-value = 5.84E-08, I²=38.5, Q test=4.88, Q test P-value = 0.181; European-ancestry phase I samples: Fixed effects P-value = 2.97E-07, Random effects P-value = 3.30E-06, I²=68.15, Q test=6.28, Q test P-value = 0.043	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs4650608	PTGFR IFI44L		T	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 1.20E-07, Random effects P-value = 9.25E-06, I²=52.26, Q test=6.28, Q test P-value = 0.099; European and Asian-ancestry phase I & phase II samples: Fixed effects P-value = 8.35E-09, Random effects P-value = 1.06E-06, I²=39.04, Q test=8.2, Q test P-value = 0.145; European-ancestry phase I samples: Fixed effects P-value = 2.10E-07, Random effects P-value = 2.29E-05, I²=61.92, Q test=5.25, Q test P-value = 0.072; European-ancestry phase I and phase II samples: Fixed effects P-value = 1.56E-08, Random effects P-value = 2.71E-06, I²=44.18, Q test=7.17, Q test P-value = 0.127	The results suggest novel association findings. The results suggest novel association findings.	Positive
rs4948418	ANK3		T	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 8.93E-09, Random effects P-value = 3.71EC10, I²=80.77, Q test=26.01, Q test P-value = 8.90E-05; European-ancestry phase I and phase II samples: Fixed effects P-value = 2.45E-08, Random effects P-value = 2.99EC10, I²=82.87, Q test=23.35, Q test P-value = 1.08E-04	Supportive evidence for prior association findings near ANK3...... Supportive evidence for prior association findings near ANK3 was also observed. More...	Positive
rs6079468	MACROD2		C	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 4.50E-07, Random effects P-value = 2.11E-05, I²=33.08, Q test=7.47, Q test P-value = 0.188; European-ancestry phase I and phase II samples: Fixed effects P-value = 7.52E-07, Random effects P-value = 0.00014, I²=0, Q test=3.95, Q test P-value = 0.413	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs6746896	LMAN2L CNNM4		A	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 3.57E-08, Random effects P-value = 4.19E-07, I²=52.07, Q test=6.26, Q test P-value = 0.1; European and Asian-ancestry phase I & phase II samples: Fixed effects P-value = 1.59E-08, Random effects P-value = 1.78E-07, I²=57.92, Q test=11.88, Q test P-value = 0.036; European-ancestry phase I samples: Fixed effects P-value = 1.66E-09, Random effects P-value = 2.62E-08, I²=0, Q test=0.55, Q test P-value = 0.761; European-ancestry phase I and phase II samples: Fixed effects P-value = 1.35E-09, Random effects P-value = 3.23E-08, I²=43.88, Q test=7.13, Q test P-value = 0.129	The results suggest novel association findings. The results suggest novel association findings.	Positive
rs7618915	PPM1M		G	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 8.92E-07, Random effects P-value = 2.04E-07, I²=0, Q test=0.29, Q test P-value = 0.866; European and Asian-ancestry phase I & phase II samples: Fixed effects P-value = 1.64E-09, Random effects P-value = 2.88EC10, I²=0, Q test=1.95, Q test P-value = 0.744; European-ancestry phase I and phase II samples: Fixed effects P-value = 1.79E-08, Random effects P-value = 8.19E-09, I²=0, Q test=1.88, Q test P-value = 0.598	The results suggest novel association findings. The results suggest novel association findings.	Positive
rs9834970	TRANK1 LRBA		C	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 2.41EC11, Random effects P-value = 3.03EC13, I²=23.98, Q test=3.95, Q test P-value = 0.267; European and Asian-ancestry phase I & phase II samples: Fixed effects P-value = 4.71EC10, Random effects P-value = 1.48EC12, I²=54.34, Q test=10.95, Q test P-value = 0.052; European-ancestry phase I samples: Fixed effects P-value = 5.65EC10, Random effects P-value = 8.03EC12, I²=48.59, Q test=3.89, Q test P-value = 0.143; European-ancestry phase I and phase II samples: Fixed effects P-value = 1.03E-08, Random effects P-value = 3.08EC11, I²=63.4, Q test=10.93, Q test P-value = 0.027	The results suggest novel association findings. The results suggest novel association findings.	Positive
rs10848642	CACNA1C CACNA1C-AS4		G	Meta-analysis results by ancestry: European and Asian-ancestry phase I samples: Fixed effects P-value = 2.80E-07, Random effects P-value = 1.61E-05, I²=56.12, Q test=11.39, Q test P-value = 0.044	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 8)

Gene	Statistical Values/Author Comments	Result Category
LMAN2L	The results suggest novel association findings near the gene. The results suggest novel association findings near the gene.	Positive
TENM4	No significant association was observed. No significant association was observed.	Negative
CACNA1C	No significant association was observed. No significant association was observed.	Negative
CADM2	No significant association was observed. No significant association was observed.	Negative
PTGFR	The results suggest novel association findings near the gene. The results suggest novel association findings near the gene.	Positive
MACROD2	No significant association was observed. No significant association was observed.	Negative
TRANK1	The results suggest novel association findings near the gene. The results suggest novel association findings near the gene.	Positive
ANK3	Supportive evidence for prior association findings near ANK3 was also observed. Supportive evidence for prior association findings near ANK3 was also observed.	Positive