SNP Report

Basic Info

Name	rs10994397 dbSNP Ensembl
Location	chr10:60519366 - 60519366(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.160144
Functional Annotation	intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000373827, ENST00000503366, ENST00000510382, ENST00000622427); NMD_transcript_variant(ENST00000622427); non_coding_transcript_variant(ENST00000510382)
No. of Studies	5 (Positive: 4; Negative: 0; Trend: 1)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 5)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Dedman, A.,2012	T/C		Association analysis: for UCL1 sample, P-value = 0.001, OR=1...... Association analysis: for UCL1 sample, P-value = 0.001, OR=1.61; for UCL2 sample, P-value = 0.53, OR=1.13; for UCL1+UCL2 sample, P-value = 0.017, OR=1.32 More...	Significant association was observed in BD. Significant association was observed in BD.	Positive
Muhleisen, T. W., 2014	T/C	T	MooDS: P-value=0.0315, OR= 1.14; PGC: P-value=5.54E-10, OR=1...... MooDS: P-value=0.0315, OR= 1.14; PGC: P-value=5.54E-10, OR=1.35; MooDS-PGC: P-value=2.00E-10, adjusted P-value=2.86E-10, OR=1.29 More...	Eighteen GWAS SNPs showing genome-wide evidence for associat...... Eighteen GWAS SNPs showing genome-wide evidence for association with BD in the combined MooDS and PGC samples. More...	Positive
Green, E. K.,2012	C/T		BD ImmunoChip:P-value = 0.923,OR = 1.01;ImmunoChip, PGC-BD c...... BD ImmunoChip:P-value = 0.923,OR = 1.01;ImmunoChip, PGC-BD combined data:P-balue = 0.00000215,OR = 0.842 More...	Suggestive association was found. Suggestive association was found.	Trend
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013	T/C		Association analysis:P-value = 0.00000000708 in BPD. Association analysis:P-value = 0.00000000708 in BPD.	Significant association was observed in BPD. Significant association was observed in BPD.	Positive
Sklar, P.,2011	C/T		Primary GWAS P-value(GC)=0.00000000708, OR=0.74; replication...... Primary GWAS P-value(GC)=0.00000000708, OR=0.74; replication P-value(1-sided)=0.116, OR=0.94; Combined GWAS and replication P-value(GC)=0.000000308, OR=0.82 More...	Significant association was found. Significant association was found.	Positive

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
ANK3	ankyrin 3, node of Ranvier (ankyrin G)	10q21	17(13/3/1)

SNPs in LD with rs10994397 (count: 0) View in gBrowse (chr10:60519366..60519366 )

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)