BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Takata, A.,2011(b) PMID: 21438140
Citation	Takata, A., S. H. Kim, et al. (2011). "Association of ANK3 with bipolar disorder confirmed in East Asia." Am J Med Genet B Neuropsychiatr Genet 156B(3): 312-315.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	2,212 cases (352 from Korea,860 from Japan, and 1,000 from Taiwan) and 2,244 controls(349 from Korea, 895 from Japan, and 1,000 from Taiwan).
SNP/Region/Marker Size	2 SNPs
Predominant Ethnicity	Mongloid
Population	Japanese,Korean and Chinese
Gender	Male/female:149/203 in BD patients and 173/176 in controls for Korean sample,424/436 in BD patients and 445/450 in controls for Japanese sample,464/536 in BD patients and 502/498 in controls for Chinese sample
Age Group	Adults : Mean age(SD)(year):25.9(6.6) in BD patients and 33.5(12.0) in controls for Korean sample,50.2(14.4) in BD patients and 49.9(13.5) in controls for Japanese sample,42.8(12.9) in BD patients and 51.7(17.8) in controls for Chinese sample

Detail Info

Sample Diagnosis	DSM
Sample Status	Korean case-control samples. A total 701 individuals of unrelated patient and control sampleswere included in this study, which consisted of 349 controls and 352 patients with BD (254 bipolar I disorder [BDI], 98 bipolar II disorder [BDII]). Participants were all ethnically Korean.Japanese COSMO case-control samples. These samples were recruited through the COSMO (Collaborative Study of Mood Disorders) consortium [Iwayama et al., 2010], which comprises 860 unrelated bipolar patients (584 BDI, 276 BDII) and 895 age- and sex-matched controls. All samples are of Japanese origin. GWASdata in Taiwan. Genotype data of twoA NK3SNPs were obtained by a GWAS in Taiwan [Lee et al., 2010] and were kindly provided by Dr. Andrew Cheng (Institute of Biomedical Sciences, Academia Sinica, Taiwan). The samples consisted of 1,000 BDI patients and 1,000 normal controls . All samples are of Han Chinese origin.
Technique	genotyping
Statistical Method	Association between markers and BD in each individual population was assessed using the chi-square test.
Result Summary	We could not detect any significant difference of allele frequency in individual analyses using each of the three populations. However, when we combined the three data sets and performed a meta-analysis, rs1938526 showed nominally significant association (P_=_0.048, odds ratio_=_1.09). The over-represented allele in BD was same as that reported in Caucasian GWASs. On the other hand, any significant association was not detected in rs10994336. This discrepancy between two SNPs may be explained by the different degree of linkage disequilibrium between Asian and Caucasian. These findings further supported the association between ANK3 and BD, and also suggested the genomic region around rs1938526 as a common risk locus across ethnicities.

SNPs reported by this study for BD (count: 2)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs1938526	ANK3	A/G	G	chi-square test: allele P-value = 0.31, OR(95%CI)=1.12(0.90-1.38) for Korean sample; allele P-value = 0.359, OR(95%CI)=1.06(0.93-1.22) for Japanese sample; allele P-value = 0.13, OR(95%CI)=1.11(0.97-1.27) for Taiwan sample	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs10994336	ANK3	C/T	T	chi-square test: allele P-value = 0.489, OR(95%CI)=0.92(0.73-1.16) for Korean sample; allele P-value = 0.918, OR(95%CI)=1.01(0.88-1.16) for Japanese sample; allele P-value = 0.214, OR(95%CI)=1.1(0.94-1.29) for Taiwan sample	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 1)