BDgene

Core Gene from Gene Prioritization Pathways from PBA (Pathway-based Analysis) Enriched Pathways for Core Genes Enriched Pathways for Cross-disorder Genes

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Basic Info

Reference	Lett, T. A.,2011 PMID: 21767209
Citation	Lett, T. A., C. C. Zai, et al. (2011). "ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype." World J Biol Psychiatry 12(5): 392-397.
Disease Type	Bipolar Disorder
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	347 bipolar patients from 312 families
SNP/Region/Marker Size	4 SNPs
Predominant Ethnicity	Caucasian
Population	Canadian
Age Group	Adults : The mean age at the time of the interview was 43.64,SD=9.93 years. Subjects'age ranged from 27 to 60 years.

Detail Info

Sample Diagnosis	DSM
Sample Status	This study was approved by the local research ethics board at the Centre for Addiction and Mental Health (CAMH). The study population consisted of 347 bipolar patients from 312 families who were recruited in the Toronto area through the CAMH. The sample included 235 bipolar I, 96 bipolar II, and 16 schizoaffective-bipolar type. Twenty-six siblings with bipolar disorder and 46 unaffected siblings were included. In addition, 45 first- or second-degree relatives were included, and 12 of these had a lifetime history of bipolar disorder. Psychosis information, according to SCID-1 diagnosis of the medical records, was available in 277 patients, of which 57% experienced lifetime psychotic symptoms ( N=158), and 67 patients attempted suicide. Participants were mainly White and European origin ( N=332, 95%), with 12 Asians, three Native Americans (0.8%) and three African-Americans (0.8%). Further details are published elsewhere (Muller et al. 2006). Our sample did not include individuals from previous GWA studies and thus represent an independent replication sample.
Technique	PCR and sequencing
Statistical Method	Association tests in the family based sample were done using Pedigree Based Association Testing (PBAT) which is implemented in Golden Helix SNP & Variation Suite 7.3.1(Golden Helix, Inc. Bozeman, MT, USA; http://www.goldenhelix.com).
Result Summary	RESULTS. In the whole sample, we found a nominal association in ZNF804A (rs1344706, P = 0.046), and a trend in CACNA1C (rs1006737, P = 0.077). In the psychotic BPD subgroup, as hypothesized, stronger signals were observed in ZNF804A (P = 0.019) and CACNA1C (P = 0.017). We found no association in the ANK3 markers, but the rs10994336 variant was nominally associated with non-psychotic BPD (P = 0.046). Exploratory analysis revealed the rs1344706 variant was also implicated in suicide-attempt behaviour (P = 0.038). CONCLUSIONS. These tentative results are consistent with the hypothesis that the subphenotype of BPD with psychosis may represent a clinical manifestation of shared genetic liability between BPD and SCZ.

SNPs reported by this study for BD (count: 4)

SNP	Related Gene(s)	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
rs9804190	ANK3	T/C	T	FBAT: P-value = 0.32	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1006737	CACNA1C	G/A	A	FBAT: P-value = 0.077	No significant association was observed in BD. No significant association was observed in BD.	Negative
rs1344706	ZNF804A	C/A	A	FBAT: P-value = 0.046	Significant association was found in BD. Significant association was found in BD.	Positive
rs10994336	ANK3	T/C	T	FBAT: P-value = 0.329	No significant association was observed in BD. No significant association was observed in BD.	Negative

Genes reported by this study for BD (count: 3)

Gene	Statistical Values/Author Comments	Result Category
CACNA1C	No significant association was observed in CACNA1C gene for BPD. No significant association was observed in CACNA1C gene for BPD.	Negative
ANK3	No significant association was observed in ANK3 gene for BPD. No significant association was observed in ANK3 gene for BPD.	Negative
ZNF804A	Our fi ndings support previous reports that the ZNF804A gene is associated with BPD. Our fi ndings support previous reports that the ZNF804A gene is associated with BPD.	Positive