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Study Report
Comment on Study | View All Comments on Study |
Reference | Ollila, H. M.,2009 PMID: 19308021 |
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Citation | Ollila, H. M., P. Soronen, et al. (2009). Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort. Mol Psychiatry 14(4): 351-353. |
Disease Type | Bipolar I Disorder |
Study Design | family-based |
Study Type | Candidate-gene association study |
Sample Size | 723 individuals from 180 families with BPI |
SNP/Region/Marker Size | 26 SNPs |
Predominant Ethnicity | Caucasian |
Population | Finnish |
Sample Diagnosis | DSM |
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Technique | genotyping |
Statistical Method | the Family Based Association Test (FBAT) |
Result Summary | Four SNPs that associated in this study were allelic replications, which further supports the role of these genes(SORCS2 and DFNB31) as probable players in BP even though the functional variants still remain to be identified. |
SNP | Related Gene(s) | Allele Change | Risk Allele | Statistical Values | Author Comments | Result Category |
---|---|---|---|---|---|---|
rs4411993 | SORCS2 MIR4274 | C/T | FBAT: P-value = 0.006045 | Significant association was observed Significant association was observed | Positive | |
rs7683874 | SORCS2 | G/A | FBAT: P-value = 0.012695 | Significant association was observed Significant association was observed | Positive | |
rs1143685 | PLCG2 | C/T | FBAT: P-value = 0.779841 | No significant association was observed No significant association was observed | Negative | |
rs9315885 | DGKH MAPK6PS3 | T/C | FBAT: P-value = 0.069024 | No significant association was observed No significant association was observed | Negative | |
rs4792948 | FZD2 | C/T | FBAT: P-value = 0.21447 | No significant association was observed No significant association was observed | Negative | |
rs942518 | DFNB31 | A/G | FBAT: P-value = 0.243882 | No significant association was observed No significant association was observed | Negative | |
rs9513877 | NALCN | G/A | FBAT: P-value = 0.840305 | No significant association was observed No significant association was observed | Negative | |
rs4806874 | SLC39A3 | A/G | FBAT: P-value = 0.034354 | No significant association was observed No significant association was observed | Negative | |
rs3761218 | CDC25B | T/C | FBAT: P-value = 0.340967 | No significant association was observed No significant association was observed | Negative | |
rs6458307 | GLTSCR1L | C/T | FBAT: P-value = 0.582353 | No significant association was observed No significant association was observed | Negative | |
rs3802477 | GABBR2 | T/C | FBAT: P-value = 0.595076 | No significant association was observed No significant association was observed | Negative | |
rs6732834 | TCF7L1 | C/T | FBAT: P-value = 0.806607 | No significant association was observed No significant association was observed | Negative | |
rs420259 | PALB2 | A/G | FBAT: P-value = 0.378765 | No significant association was observed No significant association was observed | Negative | |
rs683395 | LAMP3 | A/G | FBAT: P-value = 0.705905 | No significant association was observed No significant association was observed | Negative | |
rs4276227 | CMTM8 | C/T | FBAT: P-value = 0.758132 | No significant association was observed No significant association was observed | Negative | |
rs7204975 | RBFOX1 RNU7-99P | C/T | FBAT: P-value = 0.478677 | No significant association was observed No significant association was observed | Negative | |
rs1344484 | T/C | FBAT: P-value = 0.310807 | No significant association was observed No significant association was observed | Negative | ||
rs1375144 | DPP10 | A/G | FBAT: P-value = 0.290897 | No significant association was observed No significant association was observed | Negative | |
rs2360111 | NXN | C/T | FBAT: P-value = 0.217596 | No significant association was observed No significant association was observed | Negative | |
rs2989476 | NFIA | G/C | FBAT: P-value = 0.892598 | No significant association was observed No significant association was observed | Negative | |
rs10937823 | SORCS2 | C/T | FBAT: P-value = 0.004187 | Significant association was observed Significant association was observed | Positive | |
rs10982256 | DFNB31 | C/T | FBAT: P-value = 0.009756 | Significant association was observed Significant association was observed | Positive | |
rs11622475 | TDRD9 | C/T | FBAT: P-value = 0.781012 | No significant association was observed No significant association was observed | Negative | |
rs1170191 | DGKH | G/A | FBAT: P-value = 0.141857 | No significant association was observed No significant association was observed | Negative | |
rs10791345 | JAM3 | G/A | FBAT: P-value = 0.672997 | No significant association was observed No significant association was observed | Negative | |
rs10500336 | RBFOX1 | A/G | FBAT: P-value = 0.202177 | No significant association was observed No significant association was observed | Negative |
Gene | Statistical Values/Author Comments | Result Category |
---|---|---|
DFNB31 | we could confirm findings for this association with BPI. we could confirm findings for this association with BPI. | Positive |
PLCG2 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
FZD2 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
NXN | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
CDC25B | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
GABBR2 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
PALB2 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
JAM3 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
CMTM8 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
NALCN | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
RBFOX1 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
TCF7L1 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
SORCS2 | we could confirm findings for this association with BPI. we could confirm findings for this association with BPI. | Positive |
DGKH | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
DPP10 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
SLC39A3 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
TDRD9 | It showed no evidence for association with BPI in our study. It showed no evidence for association with BPI in our study. | Negative |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: March 31, 2016