SNP Report

Basic Info

Name	rs11622475 dbSNP Ensembl
Location	chr14:104042739 - 104042739(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.248203
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000339063, ENST00000409874, ENST00000557332)
No. of Studies	4 (Positive: 0; Negative: 1; Trend: 3)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 4)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Jiang, Y.,2011			Non-weighted test under H0: P-value(additive)=0.0000021, P-v...... Non-weighted test under H0: P-value(additive)=0.0000021, P-value(dominant)=0.0000022, P-value(recessive)=0.0195; weighted test under H'0: P-value(additive)=0.00000778, P-value(dominant)=0.00000907, P-value(recessive)=0.0142; logistic regression: P-value(additive)=0.00000241, P-value(dominant)=0.00000526, P-value(recessive)=0.00926 More...	Suggestive association was found. Suggestive association was found.	Trend
Feng, T.,2010			Fisher's exact tests: Empirical P-value(1, 000, 000 permutat...... Fisher's exact tests: Empirical P-value(1, 000, 000 permutations)=0.000027 More...	Suggestive association was found. Suggestive association was found.	Trend
The Wellcome Trust Case Control Consortium, 2007	C/T	C	Genotypic P-value = 8.14E-06; Heterozygote OR (95%CI)=1.13 ...... Genotypic P-value = 8.14E-06; Heterozygote OR (95%CI)=1.13 (0.89-1.44); Homozygote OR (95%CI)=1.47 (1.17-1.86) More...	showing moderate evidence of association with BD showing moderate evidence of association with BD	Trend
Ollila, H. M.,2009	C/T		FBAT: P-value = 0.781012 FBAT: P-value = 0.781012	No significant association was observed No significant association was observed	Negative

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
TDRD9	tudor domain containing 9	14q32.33	3(1/1/1)

SNPs in LD with rs11622475 (count: 13) View in gBrowse (chr14:103898973..104060861 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs743212		1.0[CEU]
rs12885873	downstream_gene_variant; intron_variant; upstream_gene_variant	0.949[CEU]; 0.897[TSI]
rs17101911		0.946[CEU]
rs11625697	intron_variant	1.0[CEU]
rs12050167		0.949[CEU]
rs941946	intron_variant	1.0[CEU]
rs1187448	downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]
rs12886745	downstream_gene_variant	1.0[CEU]; 1.0[TSI]
rs2236247	downstream_gene_variant	1.0[CEU]; 0.871[TSI]
rs12889168	downstream_gene_variant; intron_variant	1.0[CEU]
rs6576012	intron_variant; non_coding_transcript_variant	1.0[CEU]
rs2236246	3_prime_UTR_variant; downstream_gene_variant; intron_variant; non_coding_transcript_variant	1.0[CEU]; 0.849[TSI]
rs10149651	intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)