SNP Report

Basic Info

Name	rs10937823 dbSNP Ensembl
Location	chr4:7478695 - 7478695(1)
Variant Alleles	C/T
Ancestral Allele	C
Minor Allele	T
Minor Allele Frequence	0.144768
Functional Annotation	intron_variant; non_coding_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000329016, ENST00000507866, ENST00000511199); non_coding_transcript_variant(ENST00000511199)
No. of Studies	3 (Positive: 2; Negative: 0; Trend: 1)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Takata, A.,2011(a)	T/C		Fisher's exact test: allele P-value = 0.3432, genotype P-val...... Fisher's exact test: allele P-value = 0.3432, genotype P-value = 0.0175 More...	Significant association was found. Significant association was found.	Positive
Ollila, H. M.,2009	C/T		FBAT: P-value = 0.004187 FBAT: P-value = 0.004187	Significant association was observed Significant association was observed	Positive
Baum, A. E., 2008 (a)		C	P-value = 0.001 when genotyped individually in the test samp...... P-value = 0.001 when genotyped individually in the test sample (NIMH); P-value = 0.004 when individually genotyped in the Replication sample (German); P-value = 0.000014 in the combined dataset. OR (95% CI)=1.67 (1.32-2.13) More...	significant at the P < 0.05 level in both samples. significant at the P < 0.05 level in both samples.	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
SORCS2	sortilin-related VPS10 domain containing receptor 2	4p16.1	5(3/2/0)

SNPs in LD with rs10937823 (count: 21) View in gBrowse (chr4:7470684..7490931 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 21)

rs_ID	Functional Annotation	r²[population]
rs13152135	intron_variant; non_coding_transcript_variant	1.0[CEU]
rs16840373	intron_variant; non_coding_transcript_variant	1.0[CEU]; 0.943[CHB]; 0.946[CHD]; 0.935[JPT]
rs13353636	intron_variant; non_coding_transcript_variant	0.92[CHD]
rs16840399	intron_variant; non_coding_transcript_variant	1.0[CEU]
rs16840348	intron_variant; non_coding_transcript_variant	0.824[CEU]; 0.824[CHB]; 0.868[JPT]
rs6837019	intron_variant; non_coding_transcript_variant	1.0[CEU]
rs12506763	intron_variant; non_coding_transcript_variant	0.825[CEU]; 0.826[CHB]; 0.868[JPT]
rs13138627	intron_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.935[JPT]
rs2013388	intron_variant; non_coding_transcript_variant	1.0[CEU]
rs16840336	intron_variant; non_coding_transcript_variant	0.811[CHB]
rs16840313	intron_variant; non_coding_transcript_variant	0.823[TSI]
rs11737430	intron_variant; non_coding_transcript_variant	1.0[CEU]
rs12499489	intron_variant; non_coding_transcript_variant	0.826[CHB]; 0.868[JPT]
rs16840339	intron_variant; non_coding_transcript_variant	0.826[CHB]; 0.868[JPT]
rs12503258	intron_variant; non_coding_transcript_variant	0.825[CEU]; 0.826[CHB]; 0.868[JPT]
rs12503401	intron_variant; non_coding_transcript_variant	0.825[CEU]; 0.813[CHB]; 0.868[JPT]
rs10937822	intron_variant; non_coding_transcript_variant	1.0[CEU]; 1.0[TSI]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs16840358	intron_variant; non_coding_transcript_variant	0.825[CEU]; 0.904[TSI]; 0.826[CHB]; 0.972[CHD]; 0.868[JPT]
rs11736890	intron_variant; non_coding_transcript_variant	0.825[CEU]; 0.855[JPT]
rs11736935	intron_variant; non_coding_transcript_variant	0.825[CEU]; 0.904[TSI]; 0.826[CHB]; 1.0[CHD]; 0.868[JPT]
rs16840378	intron_variant; non_coding_transcript_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)