Gene Report

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Basic Info

Approved Symbol	CDC25B
Approved Name	cell division cycle 25B
Previous Name	cell division cycle 25B, "cell division cycle 25 homolog B (S. cerevisiae)", "cell division cycle 25 homolog B (S. pombe)"
Location	20p13
Position	chr20:3786772-3806121, 1
External Links	HGNC: 1726 Entrez Gene: 994 Ensembl: ENSG00000101224 UCSC: uc002wjn.4
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Ollila, H. M.,2009	SNP: rs3761218	It showed no evidence for association with BPI in our study.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005737	cytoplasm	cellular component	IDA	322
GO:0051301	cell division	biological process	IEA	20
GO:0001556	oocyte maturation	biological process	IEA	3
GO:0000922	spindle pole	cellular component	IDA[15908796]	6
GO:0045860	positive regulation of protein kinase activity	biological process	IEA	8
GO:0000086	G2/M transition of mitotic cell cycle	biological process	TAS[12400006]	15
GO:0006468	protein phosphorylation	biological process	IDA[17332740]	42
GO:0004725	protein tyrosine phosphatase activity	molecular function	TAS[9188863]	6
GO:0008284	positive regulation of cell proliferation	biological process	TAS[8276402]	44
GO:0035335	peptidyl-tyrosine dephosphorylation	biological process	IEA; TAS[1836978]	9
GO:0007144	female meiosis I	biological process	IEA	1
GO:0005813	centrosome	cellular component	IDA[15908796]	34
GO:0019901	protein kinase binding	molecular function	IPI[12400006]	29
GO:0000278	mitotic cell cycle	biological process	TAS[9188863]	33
GO:0032467	positive regulation of cytokinesis	biological process	IMP[17332740]	8
GO:0005515	protein binding	molecular function	IPI[10713667]	563
GO:0005829	cytosol	cellular component	TAS	223
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0045931	positive regulation of mitotic cell cycle	biological process	IMP[17332740]	2
GO:0007067	mitotic nuclear division	biological process	IEA	15

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04110	Cell cycle	8
hsa04010	MAPK signaling pathway	39

Gene related BioCarta pathways (count: 5)

ID	Name	No. of Genes in BDgene
rbPathway	RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage	2
srcRPTPPathway	Activation of Src by Protein-tyrosine phosphatase alpha	1
cdc25Pathway	cdc25 and chk1 Regulatory Pathway in response to DNA damage	2
g2Pathway	Cell Cycle: G2/M Checkpoint	2
ptc1Pathway	Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle	1

Gene related interactors from protein-protein interactions data in HPRD (count: 20)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CDC25B	CSNK2A1	YES	in vitro;in vivo	12527891
CDC25B	YWHAH	YES	in vitro;in vivo	10713667
CDC25B	YWHAZ	NO	in vitro;in vivo	10713667 , 12764136 , 17292828
CDC25B	FHL3	NO	in vitro;in vivo;yeast 2-hybrid	12681290
CDC25B	MELK	NO	in vitro;in vivo	12400006
CDC25B	SFN	NO	in vivo	15173315
CDC25B	YWHAB	NO	in vitro;in vivo	7644510 , 10713667 , 17292828
CDC25B	YWHAE	YES	in vitro;in vivo	10713667 , 7644510
CDC25B	BRSK1	NO	in vitro	15150265
CDC25B	YWHAQ	YES	in vitro;in vivo	10713667
CDC25B	ESR1	YES	in vitro;in vivo	11689696
CDC25B	CHEK1	YES	in vitro	9278511
CDC25B	AURKA	NO	in vitro;in vivo	15128871
CDC25B	KAT2B	NO	in vitro	11689696
CDC25B	CSNK2B	YES	in vivo	12527891
CDC25B	CREBBP	YES	in vitro	11689696
CDC25B	MAPK14	NO	in vitro	15629715
CDC25B	BRSK2	NO	in vitro	15150265
CDC25B	CDK1	NO	in vitro	9585407 , 9733650 , 9268380 , 9141461 , 8440392 , 12107172
CDC25B	AR	NO	in vitro	12569365

Related other genetic factors

Gene related SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3761218	chr20:3795528 - 3795528(1)	intron_variant; upstream_gene_variant	3(1/1/1)
rs4815603	chr20:3791880 - 3791880(1)	intron_variant; upstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs6116042	chr20:3796321 - 3796321(1)	5_prime_UTR_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs3761219	chr20:3795721 - 3795721(1)	intron_variant; upstream_gene_variant
rs579111	chr20:3783225 - 3783225(1)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 20	chr20:0-64444167	4 (0/3/1)
20pter-p12.3	chr20:0-9200000	1 (0/1/0)
20p13	chr20:0-5100000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr20:3786772..3806121 View in gBrowse