BDgene

SNP Report

Basic Info
Name rs1375144 dbSNP Ensembl
Location chr2:115483610 - 115483610(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele A
Minor Allele Frequence 0.468251
Functional Annotation intron_variant; NMD_transcript_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000310323, ENST00000393146, ENST00000393147, ENST00000409163, ENST00000410059, ENST00000419287, ENST00000429914, ENST00000436732, ENST00000461250, ENST00000486885, ENST00000488208); NMD_transcript_variant(ENST00000429914); non_coding_transcript_variant(ENST00000461250, ENST00000486885, ENST00000488208)
No. of Studies 3 (Positive: 0; Negative: 1; Trend: 2)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
The Wellcome Trust Case Control Consortium, 2007 A/G A Genotypic P-value = 1.31E-05; Heterozygote OR (95%CI)=1.32 ...... Genotypic P-value = 1.31E-05; Heterozygote OR (95%CI)=1.32 (1.07-1.63); Homozygote OR (95%CI)=1.59 (1.29-1.96) More... showing moderate evidence of association with BD showing moderate evidence of association with BD Trend
Ollila, H. M.,2009 A/G FBAT: P-value = 0.290897 FBAT: P-value = 0.290897 No significant association was observed No significant association was observed Negative
Jiang, Y.,2011 Non-weighted test under H0: P-value(additive)=0.00000244, P-...... Non-weighted test under H0: P-value(additive)=0.00000244, P-value(dominant)=0.0000583, P-value(recessive)=0.000268; weighted test under H'0: P-value(additive)=0.0000471, P-value(dominant)=0.000263, P-value(recessive)=0.0011; logistic regression: P-value(additive)=0.00000202, P-value(dominant)=0.0000424, P-value(recessive)=0.000311 More... Suggestive association was found. Suggestive association was found. Trend

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
DPP10 dipeptidyl-peptidase 10 (non-functional) 2q14.1 3(2/1/0)

SNPs in LD with rs1375144 (count: 40) View in gBrowse (chr2:115440072..115557686 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 40)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016