SNP Report

Basic Info

Name	rs683395 dbSNP Ensembl
Location	chr3:183152030 - 183152030(1)
Variant Alleles	G/A
Ancestral Allele	G
Minor Allele	G
Minor Allele Frequence	0.129593
Functional Annotation	downstream_gene_variant; intron_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000470251, ENST00000476015); intron_variant(ENST00000265598, ENST00000466939)
No. of Studies	3 (Positive: 0; Negative: 1; Trend: 2)
Source	Literature
Overlap with SZ?	NO
Overlap with MDD?	NO

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result Category
Ollila, H. M.,2009	A/G		FBAT: P-value = 0.705905 FBAT: P-value = 0.705905	No significant association was observed No significant association was observed	Negative
The Wellcome Trust Case Control Consortium, 2007		G	Genotypic P-value = 5.11E-06; Heterozygote OR (95%CI)=1.47 ...... Genotypic P-value = 5.11E-06; Heterozygote OR (95%CI)=1.47 (1.26-1.71); Homozygote OR (95%CI)=1.30 (0.69-2.46) More...	showing moderate evidence of association with BD showing moderate evidence of association with BD	Trend
Jiang, Y.,2011			Non-weighted test under H0: P-value(additive)=0.0000023, P-v...... Non-weighted test under H0: P-value(additive)=0.0000023, P-value(dominant)=0.000000857, P-value(recessive)=0.544; weighted test under H'0: P-value(additive)=0.0000229, P-value(dominant)=0.00000388, P-value(recessive)=0.472; logistic regression: P-value(additive)=0.00000274, P-value(dominant)=0.00000121, P-value(recessive)=0.456 More...	Suggestive association was found. Suggestive association was found.	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (Positive/Negative/Trend)
LAMP3	lysosomal-associated membrane protein 3	3q26.3-q27	1(1/0/0)

SNPs in LD with rs683395 (count: 5) View in gBrowse (chr3:183152030..183162323 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²<=0.8.

rs_ID	Functional Annotation	r²[population]
rs501833	intron_variant; non_coding_transcript_variant	0.8[CEU]
rs625677	downstream_gene_variant; intron_variant	1.0[CEU]
rs682396	downstream_gene_variant; intron_variant	1.0[CEU]; 1.0[TSI]
rs6443856	intron_variant; non_coding_transcript_variant; upstream_gene_variant	0.801[CEU]
rs6414499	downstream_gene_variant; intron_variant	1.0[CEU]

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)