BDgene

SNP Report

Basic Info
Name rs4276227 dbSNP Ensembl
Location chr3:32289194 - 32289194(1)
Variant Alleles C/T
Ancestral Allele T
Minor Allele T
Minor Allele Frequence 0.33107
Functional Annotation intron_variant.
Consequence to Transcript intron_variant(ENST00000307526, ENST00000458535)
No. of Studies 3 (Positive: 0; Negative: 1; Trend: 2)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Jiang, Y.,2011 Non-weighted test under H0: P-value(additive)=0.00000459, P-...... Non-weighted test under H0: P-value(additive)=0.00000459, P-value(dominant)=0.0000264, P-value(recessive)=0.00204; weighted test under H'0: P-value(additive)=0.0000112, P-value(dominant)=0.0000341, P-value(recessive)=0.00562; logistic regression: P-value(additive)=0.00000515, P-value(dominant)=0.0000465, P-value(recessive)=0.00124 More... Suggestive association was found. Suggestive association was found. Trend
Ollila, H. M.,2009 C/T FBAT: P-value = 0.758132 FBAT: P-value = 0.758132 No significant association was observed No significant association was observed Negative
The Wellcome Trust Case Control Consortium, 2007 C/T C Genotypic P-value = 2.62E-05; Heterozygote OR (95%CI)=1.20 ...... Genotypic P-value = 2.62E-05; Heterozygote OR (95%CI)=1.20 (0.99-1.46); Homozygote OR (95%CI)=1.49 (1.23-1.81) More... showing moderate evidence of association with BD showing moderate evidence of association with BD Trend

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 3p22.2 2(1/1/0)

SNPs in LD with rs4276227 (count: 4) View in gBrowse (chr3:32289194..32304207 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 4)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016