Study Report

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Basic Info

Reference	Jiang, Y.,2011 PMID: 21254220
Citation	Jiang, Y. and H. Zhang (2011). "Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder." Genet Epidemiol 35(2): 125-132.
Disease Type	Bipolar Disorder
Study Design	case-control
Study Type	Genome-wide association study
Sample Size	1,998 BD cases and 3,004 controls
Predominant Ethnicity
Population	WTCCC collection

Detail Info

Statistical Method	a covariate-adjusted parametric test
Result Summary	When compared to other tests, our test identified an unreported region with three single nucleotide polymorphisms (SNPs) on chromosome 16 that show strong evidence of association (P-value <5 E-07). This region is near the RPGRIP1L gene known to be associated with BD. A haplotype block including these three SNPs was further discovered to be strongly associated with BD. It is also interesting to note that our nonparametric test did not reveal strong signals at two SNPs that were detected by a covariate-adjusted parametric test. This suggests that different methods of covariate adjustment can complement each other. Thus, we recommend using both parametric and nonparametric testing. Additionally, we performed simulation studies to compare our proposed test with the unadjusted test and an adjusted parametric test. Our finding underscores the importance of accommodating and controlling for covariate effects in discovering genetic variants associated with complex disorders.

SNPs reported by this study for BD (count: 61)

SNP	Related Gene(s)	Statistical Values	Author Comments	Result Category
rs7247513	ZNF490	Non-weighted test under H0: P-value(additive)=0.00000207, P-value(dominant)=0.0000894, P-value(recessive)=0.000108; weighted test under H'0: P-value(additive)=0.00000554, P-value(dominant)=0.000202, P-value(recessive)=0.00011; logistic regression: P-value(additive)=0.00000396, P-value(dominant)=0.00019, P-value(recessive)=0.0000919	Suggestive association was found. Suggestive association was found.	Trend
rs7248493	ZNF274	Non-weighted test under H0: P-value(additive)=0.0000308, P-value(dominant)=0.000043, P-value(recessive)=0.0424; weighted test under H'0: P-value(additive)=0.000014, P-value(dominant)=0.0000246, P-value(recessive)=0.0108; logistic regression: P-value(additive)=0.00000604, P-value(dominant)=0.0000231, P-value(recessive)=0.00678	Suggestive association was found. Suggestive association was found.	Trend
rs7296288	DHH	Non-weighted test under H0: P-value(additive)=0.000492, P-value(dominant)=0.0000276, P-value(recessive)=0.172; weighted test under H'0: P-value(additive)=0.000205, P-value(dominant)=0.0000096, P-value(recessive)=0.0815; logistic regression: P-value(additive)=0.000191, P-value(dominant)=0.0000149, P-value(recessive)=0.0992	Suggestive association was found. Suggestive association was found.	Trend
rs7570682		Non-weighted test under H0: P-value(additive)=0.00000312, P-value(dominant)=0.0000337, P-value(recessive)=0.000906; weighted test under H'0: P-value(additive)=0.00000875, P-value(dominant)=0.00016, P-value(recessive)=0.000195; logistic regression: P-value(additive)=0.00000801, P-value(dominant)=0.000144, P-value(recessive)=0.000414	Suggestive association was found. Suggestive association was found.	Trend
rs7896131		Non-weighted test under H0: P-value(additive)=0.000156, P-value(dominant)=0.0000135, P-value(recessive)=0.825; weighted test under H'0: P-value(additive)=0.000265, P-value(dominant)=0.000024, P-value(recessive)=0.717; logistic regression: P-value(additive)=0.000114, P-value(dominant)=0.00000912, P-value(recessive)=0.829	Suggestive association was found. Suggestive association was found.	Trend
rs8021692	TDRD9	Non-weighted test under H0: P-value(additive)=0.00000298, P-value(dominant)=0.00000362, P-value(recessive)=0.0167; weighted test under H'0: P-value(additive)=0.000016, P-value(dominant)=0.0000197, P-value(recessive)=0.00939; logistic regression: P-value(additive)=0.00000364, P-value(dominant)=0.00000948, P-value(recessive)=0.00758	Suggestive association was found. Suggestive association was found.	Trend
rs8031347		Non-weighted test under H0: P-value(additive)=0.0000782, P-value(dominant)=0.0000769, P-value(recessive)=0.0646; weighted test under H'0: P-value(additive)=0.00000799, P-value(dominant)=0.0000193, P-value(recessive)=0.0309; logistic regression: P-value(additive)=0.0000253, P-value(dominant)=0.0000316, P-value(recessive)=0.0366	Suggestive association was found. Suggestive association was found.	Trend
rs8056052		Non-weighted test under H0: P-value(additive)=0.00000423, P-value(dominant)=0.000091, P-value(recessive)=0.000357; weighted test under H'0: P-value(additive)=0.00000273, P-value(dominant)=0.00011, P-value(recessive)=0.000439; logistic regression: P-value(additive)=0.00000447, P-value(dominant)=0.0000847, P-value(recessive)=0.000427	Suggestive association was found. Suggestive association was found.	Trend
rs6414498	LAMP3	Non-weighted test under H0: P-value(additive)=0.00000473, P-value(dominant)=0.000000895, P-value(recessive)=0.876; weighted test under H'0: P-value(additive)=0.0000536, P-value(dominant)=0.00000485, P-value(recessive)=0.725; logistic regression: P-value(additive)=0.00000538, P-value(dominant)=0.00000117, P-value(recessive)=0.794	Suggestive association was found. Suggestive association was found.	Trend
rs6414500	LAMP3	Non-weighted test under H0: P-value(additive)=0.00000514, P-value(dominant)=0.00000081, P-value(recessive)=0.975; weighted test under H'0: P-value(additive)=0.0000659, P-value(dominant)=0.00000422, P-value(recessive)=0.9; logistic regression: P-value(additive)=0.00000586, P-value(dominant)=0.00000106, P-value(recessive)=0.946	Suggestive association was found. Suggestive association was found.	Trend
rs6458307	GLTSCR1L	Non-weighted test under H0: P-value(additive)=0.343, P-value(dominant)=0.211, P-value(recessive)=0.0000282; weighted test under H'0: P-value(additive)=0.167, P-value(dominant)=0.26, P-value(recessive)=0.00000787; logistic regression: P-value(additive)=0.284, P-value(dominant)=0.244, P-value(recessive)=0.000019	Suggestive association was found. Suggestive association was found.	Trend
rs6574988		Non-weighted test under H0: P-value(additive)=0.00000566, P-value(dominant)=0.00000422, P-value(recessive)=0.37; weighted test under H'0: P-value(additive)=0.0000311, P-value(dominant)=0.0000157, P-value(recessive)=0.51; logistic regression: P-value(additive)=0.0000159, P-value(dominant)=0.0000105, P-value(recessive)=0.477	Suggestive association was found. Suggestive association was found.	Trend
rs6741692	DPP10	Non-weighted test under H0: P-value(additive)=0.00000465, P-value(dominant)=0.0000401, P-value(recessive)=0.00136; weighted test under H'0: P-value(additive)=0.0000748, P-value(dominant)=0.000139, P-value(recessive)=0.00456; logistic regression: P-value(additive)=0.00000585, P-value(dominant)=0.00005, P-value(recessive)=0.00147	Suggestive association was found. Suggestive association was found.	Trend
rs683395	LAMP3	Non-weighted test under H0: P-value(additive)=0.0000023, P-value(dominant)=0.000000857, P-value(recessive)=0.544; weighted test under H'0: P-value(additive)=0.0000229, P-value(dominant)=0.00000388, P-value(recessive)=0.472; logistic regression: P-value(additive)=0.00000274, P-value(dominant)=0.00000121, P-value(recessive)=0.456	Suggestive association was found. Suggestive association was found.	Trend
rs6844851		Non-weighted test under H0: P-value(additive)=0.0000376, P-value(dominant)=0.000000941, P-value(recessive)=0.271; weighted test under H'0: P-value(additive)=0.00198, P-value(dominant)=0.0000625, P-value(recessive)=0.296; logistic regression: P-value(additive)=0.0000415, P-value(dominant)=0.00000124, P-value(recessive)=0.267	Suggestive association was found. Suggestive association was found.	Trend
rs7136898	SOX5	Non-weighted test under H0: P-value(additive)=0.0000132, P-value(dominant)=0.000013, P-value(recessive)=0.00833; weighted test under H'0: P-value(additive)=0.0000224, P-value(dominant)=0.0000744, P-value(recessive)=0.0219; logistic regression: P-value(additive)=0.00000684, P-value(dominant)=0.0000111, P-value(recessive)=0.00434	Suggestive association was found. Suggestive association was found.	Trend
rs9378249	HLA-B	Non-weighted test under H0: P-value(additive)=0.0000000121, P-value(dominant)=0.0000000511, P-value(recessive)=0.00506; weighted test under H'0: P-value(additive)=0.0000000139, P-value(dominant)=0.0000000341, P-value(recessive)=0.00755; logistic regression: P-value(additive)=0.00000000171, P-value(dominant)=0.0000000077, P-value(recessive)=0.000887	Significant associations were found . Significant associations were found .	Positive
rs914715	TLE4	Non-weighted test under H0: P-value(additive)=0.00000228, P-value(dominant)=0.00000126, P-value(recessive)=0.956; weighted test under H'0: P-value(additive)=0.00000171, P-value(dominant)=0.00000214, P-value(recessive)=0.766; logistic regression: P-value(additive)=0.00000102, P-value(dominant)=0.000000705, P-value(recessive)=0.729	Suggestive association was found. Suggestive association was found.	Trend
rs9530460	LMO7 FAM204CP	Non-weighted test under H0: P-value(additive)=0.00186, P-value(dominant)=0.412, P-value(recessive)=0.000014; weighted test under H'0: P-value(additive)=0.000458, P-value(dominant)=0.287, P-value(recessive)=0.00000216; logistic regression: P-value(additive)=0.000788, P-value(dominant)=0.294, P-value(recessive)=0.00000702	Suggestive association was found. Suggestive association was found.	Trend
rs2387823		Non-weighted test under H0: P-value(additive)=0.0000029, P-value(dominant)=0.0000463, P-value(recessive)=0.000398; weighted test under H'0: P-value(additive)=0.00000013, P-value(dominant)=0.0000532, P-value(recessive)=0.000298; logistic regression: P-value(additive)=0.00000177, P-value(dominant)=0.0000311, P-value(recessive)=0.000311	Significant associations were found . Significant associations were found .	Positive
rs2421104	DPP10	Non-weighted test under H0: P-value(additive)=0.00000955, P-value(dominant)=0.000332, P-value(recessive)=0.000172; weighted test under H'0: P-value(additive)=0.0000476, P-value(dominant)=0.00103, P-value(recessive)=0.000157; logistic regression: P-value(additive)=0.00000537, P-value(dominant)=0.000204, P-value(recessive)=0.000127	Suggestive association was found. Suggestive association was found.	Trend
rs2192859		Non-weighted test under H0: P-value(additive)=0.00000188, P-value(dominant)=0.0000282, P-value(recessive)=0.000441; weighted test under H'0: P-value(additive)=0.00000244, P-value(dominant)=0.00000351, P-value(recessive)=0.000914; logistic regression: P-value(additive)=0.00000126, P-value(dominant)=0.0000145, P-value(recessive)=0.000546	Suggestive association was found. Suggestive association was found.	Trend
rs2286492	FAM126A	Non-weighted test under H0: P-value(additive)=0.506, P-value(dominant)=0.698, P-value(recessive)=0.0000084; weighted test under H'0: P-value(additive)=0.356, P-value(dominant)=0.88, P-value(recessive)=0.00000858; logistic regression: P-value(additive)=0.473, P-value(dominant)=0.736, P-value(recessive)=0.00000935	Suggestive association was found. Suggestive association was found.	Trend
rs1893146		Non-weighted test under H0: P-value(additive)=0.0000815, P-value(dominant)=0.000171, P-value(recessive)=0.045; weighted test under H'0: P-value(additive)=0.00000583, P-value(dominant)=0.0000158, P-value(recessive)=0.00792; logistic regression: P-value(additive)=0.0000505, P-value(dominant)=0.0001, P-value(recessive)=0.0479	Suggestive association was found. Suggestive association was found.	Trend
rs203097	CA10	Non-weighted test under H0: P-value(additive)=0.00201, P-value(dominant)=0.0733, P-value(recessive)=0.000045; weighted test under H'0: P-value(additive)=0.000372, P-value(dominant)=0.0248, P-value(recessive)=0.00000959; logistic regression: P-value(additive)=0.00155, P-value(dominant)=0.0664, P-value(recessive)=0.0000223	Suggestive association was found. Suggestive association was found.	Trend
rs1568889		Non-weighted test under H0: P-value(additive)=0.00145, P-value(dominant)=0.101, P-value(recessive)=0.00000232; weighted test under H'0: P-value(additive)=0.00294, P-value(dominant)=0.152, P-value(recessive)=0.0000277; logistic regression: P-value(additive)=0.00305, P-value(dominant)=0.157, P-value(recessive)=0.00000228	Suggestive association was found. Suggestive association was found.	Trend
rs17600642	ADAMTS14	Non-weighted test under H0: P-value(additive)=0.00000519, P-value(dominant)=0.00000807, P-value(recessive)=0.0334; weighted test under H'0: P-value(additive)=0.0000238, P-value(dominant)=0.0000378, P-value(recessive)=0.0538; logistic regression: P-value(additive)=0.0000501, P-value(dominant)=0.0000744, P-value(recessive)=0.0543	Suggestive association was found. Suggestive association was found.	Trend
rs1420239		Non-weighted test under H0: P-value(additive)=0.0000448, P-value(dominant)=0.000114, P-value(recessive)=0.0138; weighted test under H'0: P-value(additive)=0.00000756, P-value(dominant)=0.0000512, P-value(recessive)=0.00603; logistic regression: P-value(additive)=0.0000549, P-value(dominant)=0.000144, P-value(recessive)=0.0143	Suggestive association was found. Suggestive association was found.	Trend
rs1461356		Non-weighted test under H0: P-value(additive)=0.0000276, P-value(dominant)=0.00000463, P-value(recessive)=0.0391; weighted test under H'0: P-value(additive)=0.0000305, P-value(dominant)=0.00000485, P-value(recessive)=0.0637; logistic regression: P-value(additive)=0.0000392, P-value(dominant)=0.00000674, P-value(recessive)=0.042	Suggestive association was found. Suggestive association was found.	Trend
rs1344485		Non-weighted test under H0: P-value(additive)=0.00000178, P-value(dominant)=0.0000309, P-value(recessive)=0.000377; weighted test under H'0: P-value(additive)=0.000000179, P-value(dominant)=0.0000134, P-value(recessive)=0.000629; logistic regression: P-value(additive)=0.00000141, P-value(dominant)=0.000018, P-value(recessive)=0.000512	Significant associations were found . Significant associations were found .	Positive
rs1375144	DPP10	Non-weighted test under H0: P-value(additive)=0.00000244, P-value(dominant)=0.0000583, P-value(recessive)=0.000268; weighted test under H'0: P-value(additive)=0.0000471, P-value(dominant)=0.000263, P-value(recessive)=0.0011; logistic regression: P-value(additive)=0.00000202, P-value(dominant)=0.0000424, P-value(recessive)=0.000311	Suggestive association was found. Suggestive association was found.	Trend
rs13074575	PTPRG	Non-weighted test under H0: P-value(additive)=0.0000349, P-value(dominant)=0.0000116, P-value(recessive)=0.79; weighted test under H'0: P-value(additive)=0.0000874, P-value(dominant)=0.00002, P-value(recessive)=0.958; logistic regression: P-value(additive)=0.0000317, P-value(dominant)=0.00000877, P-value(recessive)=0.95	Suggestive association was found. Suggestive association was found.	Trend
rs1344484		Non-weighted test under H0: P-value(additive)=0.00000165, P-value(dominant)=0.0000262, P-value(recessive)=0.000397; weighted test under H'0: P-value(additive)=0.00000096, P-value(dominant)=0.00000749, P-value(recessive)=0.000674; logistic regression: P-value(additive)=0.00000107, P-value(dominant)=0.0000128, P-value(recessive)=0.000498	Suggestive association was found. Suggestive association was found.	Trend
rs12890287	SLC35F4	Non-weighted test under H0: P-value(additive)=0.0000206, P-value(dominant)=0.000011, P-value(recessive)=0.385; weighted test under H'0: P-value(additive)=0.00000709, P-value(dominant)=0.00000263, P-value(recessive)=0.463; logistic regression: P-value(additive)=0.0000152, P-value(dominant)=0.00000613, P-value(recessive)=0.491	Suggestive association was found. Suggestive association was found.	Trend
rs12938916	RN7SKP94	Non-weighted test under H0: P-value(additive)=0.000000815, P-value(dominant)=0.00000048, P-value(recessive)=0.281; weighted test under H'0: P-value(additive)=0.00000205, P-value(dominant)=0.00000111, P-value(recessive)=0.375; logistic regression: P-value(additive)=0.00000147, P-value(dominant)=0.000000889, P-value(recessive)=0.182	Significant associations were found . Significant associations were found .	Positive
rs589445	LAMP3	Non-weighted test under H0: P-value(additive)=0.00000445, P-value(dominant)=0.000000834, P-value(recessive)=0.827; weighted test under H'0: P-value(additive)=0.0000556, P-value(dominant)=0.00000514, P-value(recessive)=0.817; logistic regression: P-value(additive)=0.00000499, P-value(dominant)=0.00000122, P-value(recessive)=0.675	Suggestive association was found. Suggestive association was found.	Trend
rs514636	LAMP3	Non-weighted test under H0: P-value(additive)=0.0000025, P-value(dominant)=0.000000745, P-value(recessive)=0.722; weighted test under H'0: P-value(additive)=0.0000264, P-value(dominant)=0.0000047, P-value(recessive)=0.949; logistic regression: P-value(additive)=0.00000445, P-value(dominant)=0.00000131, P-value(recessive)=0.674	Suggestive association was found. Suggestive association was found.	Trend
rs4815603	CDC25B	Non-weighted test under H0: P-value(additive)=0.0000751, P-value(dominant)=0.000003, P-value(recessive)=0.205; weighted test under H'0: P-value(additive)=0.000933, P-value(dominant)=0.0000142, P-value(recessive)=0.0639; logistic regression: P-value(additive)=0.0000182, P-value(dominant)=0.00000048, P-value(recessive)=0.169	Significant associations were found . Significant associations were found .	Positive
rs4803595		Non-weighted test under H0: P-value(additive)=0.000061, P-value(dominant)=0.000207, P-value(recessive)=0.00796; weighted test under H'0: P-value(additive)=0.0000432, P-value(dominant)=0.000187, P-value(recessive)=0.00331; logistic regression: P-value(additive)=0.00000984, P-value(dominant)=0.0000366, P-value(recessive)=0.00408	Suggestive association was found. Suggestive association was found.	Trend
rs4739466		Non-weighted test under H0: P-value(additive)=0.199, P-value(dominant)=0.656, P-value(recessive)=0.0000036; weighted test under H'0: P-value(additive)=0.617, P-value(dominant)=0.915, P-value(recessive)=0.0000176; logistic regression: P-value(additive)=0.2, P-value(dominant)=0.619, P-value(recessive)=0.0000114	Suggestive association was found. Suggestive association was found.	Trend
rs4627791	CMTM8	Non-weighted test under H0: P-value(additive)=0.00000238, P-value(dominant)=0.00000773, P-value(recessive)=0.0035; weighted test under H'0: P-value(additive)=0.00000634, P-value(dominant)=0.0000159, P-value(recessive)=0.00191; logistic regression: P-value(additive)=0.0000046, P-value(dominant)=0.0000218, P-value(recessive)=0.00284	Suggestive association was found. Suggestive association was found.	Trend
rs4567706		Non-weighted test under H0: P-value(additive)=0.0000155, P-value(dominant)=0.0000746, P-value(recessive)=0.00488; weighted test under H'0: P-value(additive)=0.00000401, P-value(dominant)=0.0000263, P-value(recessive)=0.00489; logistic regression: P-value(additive)=0.00000622, P-value(dominant)=0.0000373, P-value(recessive)=0.00246	Suggestive association was found. Suggestive association was found.	Trend
rs4276227	CMTM8	Non-weighted test under H0: P-value(additive)=0.00000459, P-value(dominant)=0.0000264, P-value(recessive)=0.00204; weighted test under H'0: P-value(additive)=0.0000112, P-value(dominant)=0.0000341, P-value(recessive)=0.00562; logistic regression: P-value(additive)=0.00000515, P-value(dominant)=0.0000465, P-value(recessive)=0.00124	Suggestive association was found. Suggestive association was found.	Trend
rs420259	PALB2	Non-weighted test under H0: P-value(additive)=0.000219, P-value(dominant)=0.0966, P-value(recessive)=0.00000000851; weighted test under H'0: P-value(additive)=0.000647, P-value(dominant)=0.12, P-value(recessive)=0.0000000659; logistic regression: P-value(additive)=0.000426, P-value(dominant)=0.151, P-value(recessive)=0.00000000333	Significant associations were found . Significant associations were found .	Positive
rs4027132	LPIN1	Non-weighted test under H0: P-value(additive)=0.0000131, P-value(dominant)=0.0092, P-value(recessive)=0.00000309; weighted test under H'0: P-value(additive)=0.0000174, P-value(dominant)=0.00703, P-value(recessive)=0.0000142; logistic regression: P-value(additive)=0.0000135, P-value(dominant)=0.00656, P-value(recessive)=0.00000561	Suggestive association was found. Suggestive association was found.	Trend
rs3761218	CDC25B	Non-weighted test under H0: P-value(additive)=0.0000444, P-value(dominant)=0.00000113, P-value(recessive)=0.214; weighted test under H'0: P-value(additive)=0.00053, P-value(dominant)=0.00000327, P-value(recessive)=0.0713; logistic regression: P-value(additive)=0.0000116, P-value(dominant)=0.000000216, P-value(recessive)=0.173	Significant associations were found . Significant associations were found .	Positive
rs2989476	NFIA	Non-weighted test under H0: P-value(additive)=0.0000227, P-value(dominant)=0.0000022, P-value(recessive)=0.0461; weighted test under H'0: P-value(additive)=0.0000266, P-value(dominant)=0.00000225, P-value(recessive)=0.0727; logistic regression: P-value(additive)=0.0000403, P-value(dominant)=0.00000323, P-value(recessive)=0.0606	Suggestive association was found. Suggestive association was found.	Trend
rs2953146	RNPEPL1	Non-weighted test under H0: P-value(additive)=0.00000673, P-value(dominant)=0.000442, P-value(recessive)=0.0000121; weighted test under H'0: P-value(additive)=0.0000342, P-value(dominant)=0.00101, P-value(recessive)=0.0000473; logistic regression: P-value(additive)=0.0000157, P-value(dominant)=0.000864, P-value(recessive)=0.0000117	Suggestive association was found. Suggestive association was found.	Trend
rs2806922		Non-weighted test under H0: P-value(additive)=0.0079, P-value(dominant)=0.342, P-value(recessive)=0.0000182; weighted test under H'0: P-value(additive)=0.0342, P-value(dominant)=0.4, P-value(recessive)=0.000024; logistic regression: P-value(additive)=0.00554, P-value(dominant)=0.363, P-value(recessive)=0.00000461	Suggestive association was found. Suggestive association was found.	Trend
rs2609653		Non-weighted test under H0: P-value(additive)=0.00000687, P-value(dominant)=0.000021, P-value(recessive)=0.0141; weighted test under H'0: P-value(additive)=0.0000348, P-value(dominant)=0.0000411, P-value(recessive)=0.0383; logistic regression: P-value(additive)=0.0000157, P-value(dominant)=0.0000462, P-value(recessive)=0.0154	Suggestive association was found. Suggestive association was found.	Trend
rs2576561	MMP2	Non-weighted test under H0: P-value(additive)=0.0000299, P-value(dominant)=0.0000291, P-value(recessive)=0.126; weighted test under H'0: P-value(additive)=0.0000122, P-value(dominant)=0.0000045, P-value(recessive)=0.251; logistic regression: P-value(additive)=0.0000781, P-value(dominant)=0.0000631, P-value(recessive)=0.19	Suggestive association was found. Suggestive association was found.	Trend
rs11622600	SLC35F4	Non-weighted test under H0: P-value(additive)=0.000017, P-value(dominant)=0.0000102, P-value(recessive)=0.366; weighted test under H'0: P-value(additive)=0.00000531, P-value(dominant)=0.00000206, P-value(recessive)=0.393; logistic regression: P-value(additive)=0.0000118, P-value(dominant)=0.00000551, P-value(recessive)=0.461	Suggestive association was found. Suggestive association was found.	Trend
rs11622475	TDRD9	Non-weighted test under H0: P-value(additive)=0.0000021, P-value(dominant)=0.0000022, P-value(recessive)=0.0195; weighted test under H'0: P-value(additive)=0.00000778, P-value(dominant)=0.00000907, P-value(recessive)=0.0142; logistic regression: P-value(additive)=0.00000241, P-value(dominant)=0.00000526, P-value(recessive)=0.00926	Suggestive association was found. Suggestive association was found.	Trend
rs11647459		Non-weighted test under H0: P-value(additive)=0.00000293, P-value(dominant)=0.0000364, P-value(recessive)=0.000633; weighted test under H'0: P-value(additive)=0.000000276, P-value(dominant)=0.00000416, P-value(recessive)=0.000839; logistic regression: P-value(additive)=0.00000189, P-value(dominant)=0.0000183, P-value(recessive)=0.000759	Significant associations were found . Significant associations were found .	Positive
rs11640993		Non-weighted test under H0: P-value(additive)=0.00000342, P-value(dominant)=0.0000477, P-value(recessive)=0.000557; weighted test under H'0: P-value(additive)=0.00000135, P-value(dominant)=0.0000125, P-value(recessive)=0.00017; logistic regression: P-value(additive)=0.00000205, P-value(dominant)=0.0000279, P-value(recessive)=0.000501	Suggestive association was found. Suggestive association was found.	Trend
rs11123306	DPP10	Non-weighted test under H0: P-value(additive)=0.00000279, P-value(dominant)=0.000076, P-value(recessive)=0.000224; weighted test under H'0: P-value(additive)=0.0000376, P-value(dominant)=0.000098, P-value(recessive)=0.000886; logistic regression: P-value(additive)=0.00000245, P-value(dominant)=0.0000567, P-value(recessive)=0.000275	Suggestive association was found. Suggestive association was found.	Trend
rs10982256	DFNB31	Non-weighted test under H0: P-value(additive)=0.00000882, P-value(dominant)=0.000585, P-value(recessive)=0.000121; weighted test under H'0: P-value(additive)=0.00000529, P-value(dominant)=0.000351, P-value(recessive)=0.000201; logistic regression: P-value(additive)=0.0000105, P-value(dominant)=0.000411, P-value(recessive)=0.000239	Suggestive association was found. Suggestive association was found.	Trend
rs1133353	CAPN10 RNPEPL1 CAPN10-AS1	Non-weighted test under H0: P-value(additive)=0.00000643, P-value(dominant)=0.000134, P-value(recessive)=0.000115; weighted test under H'0: P-value(additive)=0.0000053, P-value(dominant)=0.000127, P-value(recessive)=0.00014; logistic regression: P-value(additive)=0.00000782, P-value(dominant)=0.000126, P-value(recessive)=0.000175	Suggestive association was found. Suggestive association was found.	Trend
rs11168839	RHEBL1 KMT2D	Non-weighted test under H0: P-value(additive)=0.000238, P-value(dominant)=0.0000263, P-value(recessive)=0.18; weighted test under H'0: P-value(additive)=0.0000872, P-value(dominant)=0.00000875, P-value(recessive)=0.124; logistic regression: P-value(additive)=0.0000706, P-value(dominant)=0.000011, P-value(recessive)=0.0948	Suggestive association was found. Suggestive association was found.	Trend
rs10779279	ESRRG	Non-weighted test under H0: P-value(additive)=0.0000399, P-value(dominant)=0.0000608, P-value(recessive)=0.0789; weighted test under H'0: P-value(additive)=0.00000893, P-value(dominant)=0.0000229, P-value(recessive)=0.0967; logistic regression: P-value(additive)=0.0000265, P-value(dominant)=0.0000362, P-value(recessive)=0.0911	Suggestive association was found. Suggestive association was found.	Trend
rs10134944	SLC35F4	Non-weighted test under H0: P-value(additive)=0.00000322, P-value(dominant)=0.00000115, P-value(recessive)=0.479; weighted test under H'0: P-value(additive)=0.00000396, P-value(dominant)=0.000000745, P-value(recessive)=0.678; logistic regression: P-value(additive)=0.00000246, P-value(dominant)=0.000000793, P-value(recessive)=0.507	Suggestive association was found. Suggestive association was found.	Trend