BDgene

SNP Report

Basic Info
Name rs4027132 dbSNP Ensembl
Location chr2:11897366 - 11897366(1)
Variant Alleles G/A
Ancestral Allele A
Minor Allele G
Minor Allele Frequence 0.459265
Functional Annotation intron_variant; non_coding_transcript_variant.
Consequence to Transcript intron_variant(ENST00000438292); non_coding_transcript_variant(ENST00000438292)
No. of Studies 3 (Positive: 0; Negative: 0; Trend: 3)
Source Literature
Overlap with SZ? NO
Overlap with MDD? NO

SNP related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result Category
Hamshere, M. L.,2009 lambda-corrected Cochran-Armitage trend test: P-value = 6.63...... lambda-corrected Cochran-Armitage trend test: P-value = 6.63E-06 More... one of independently associated SNPs that exceed a significa...... one of independently associated SNPs that exceed a significance threshold of P-value E-05(all of which have good quality clusterplots) More... Trend
Jiang, Y.,2011 Non-weighted test under H0: P-value(additive)=0.0000131, P-v...... Non-weighted test under H0: P-value(additive)=0.0000131, P-value(dominant)=0.0092, P-value(recessive)=0.00000309; weighted test under H'0: P-value(additive)=0.0000174, P-value(dominant)=0.00703, P-value(recessive)=0.0000142; logistic regression: P-value(additive)=0.0000135, P-value(dominant)=0.00656, P-value(recessive)=0.00000561 More... Suggestive association was found. Suggestive association was found. Trend
The Wellcome Trust Case Control Consortium, 2007 A/G A Genotypic P-value = 9.68E-06; Heterozygote OR (95%CI)=1.39 ...... Genotypic P-value = 9.68E-06; Heterozygote OR (95%CI)=1.39 (1.19-1.64); Homozygote OR (95%CI)=1.51 (1.27-1.79) More... showing moderate evidence of association with BD showing moderate evidence of association with BD Trend

SNP related genes (count: 1)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
LPIN1 lipin 1 2p25.1 1(0/0/1)

SNPs in LD with rs4027132 (count: 1) View in gBrowse (chr2:11897366..11901816 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2<=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 1)


Overlap with SZ from cross-disorder studies (count: 0)

Overlap with MDD from cross-disorder studies (count: 0)