BDgene

Region Report

Basic Info
Region Name Chr 14
Chromosome Position chr14:0-107043718
No. of Studies (Positive/Negative/Trend)  2(0/2/0)

Region related studies (count: 2)
Reference Markers Statistical Values Author Comments Result Category
Murphy, V. E.,2000 D14S281 Linkage analysis: broad model, NPL = -0.043, P-value = 0.52;...... Linkage analysis: broad model, NPL = -0.043, P-value = 0.52; narrow model, NPL = 0.222, P-value = 0.37 More... No significant linkage was found in this region. No significant linkage was found in this region. Negative
Avramopoulos, D., 2007 D14S288 (BPI, BPII & BPI, restricted) P-value = 0.07, NPL = 1.47, Dominant Max HLOD = 0.49, Rec...... P-value = 0.07, NPL = 1.47, Dominant Max HLOD = 0.49, Recessive Max HLOD = 0.68 in Ashkenazi pedigrees; P-value = 0.06, NPL = 1.57, Dominant Max HLOD = 0.52, Recessive Max HLOD = 0.89 in BPI-restricted pedigrees More... the absolute value of the resulting scores remained moderate the absolute value of the resulting scores remained moderate Negative

Region related genes (count: 51)
Approved Symbol Approved Name Location No. of Studies (Positive/Negative/Trend)
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 14q24.3 1(1/0/0)
KLHDC1 kelch domain containing 1 14q21.3 2(1/0/1)
PTGR2 prostaglandin reductase 2 14q24.1-q24.2 1(1/0/0)
MIR2392 microRNA 2392 14 1(0/1/0)
ZFYVE21 zinc finger, FYVE domain containing 21 14q32.33 1(0/1/0)
NUMB numb homolog (Drosophila) 14q24.3 1(0/0/1)
RNASE4 ribonuclease, RNase A family, 4 14q11 1(0/1/0)
LRRC74A leucine rich repeat containing 74A 14q24.3 1(0/1/0)
AKT1 v-akt murine thymoma viral oncogene homolog 1 14q32.33 3(3/0/0)
C14orf166B leucine rich repeat containing 74A 14q24.3 0
NRXN3 neurexin 3 14q31 2(2/0/0)
GSTZ1 glutathione S-transferase zeta 1 14q24.3 1(1/0/0)
C14orf80 chromosome 14 open reading frame 80 14q32.33 1(0/1/0)
GEMIN2 gem (nuclear organelle) associated protein 2 14q21.1 1(0/1/0)
BDKRB1 bradykinin receptor B1 14q32.1-q32.2 1(1/0/0)
MIPOL1 mirror-image polydactyly 1 14q13.3 1(0/0/1)
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 14q32.31 1(0/1/0)
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 14q32.32 1(0/1/0)
GCH1 GTP cyclohydrolase 1 14q22.1-q22.2 2(1/1/0)
DIO3 deiodinase, iodothyronine, type III 14q32 1(0/1/0)
KCNK10 potassium channel, two pore domain subfamily K, member 10 14q31 1(1/0/0)
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 14q32.13 1(1/0/0)
ADSSL1 adenylosuccinate synthase like 1 14q32.33 1(0/1/0)
TRIM9 tripartite motif containing 9 14q21.3 1(0/1/0)
KIF26A kinesin family member 26A 14q32.33 1(0/1/0)
DIO2 deiodinase, iodothyronine, type II 14q24.2-q24.3 1(1/0/0)
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 14q24 2(1/1/0)
FOXN3 forkhead box N3 14q32.11 1(1/0/0)
RCOR1 REST corepressor 1 14q32.33 1(0/1/0)
CEP170B centrosomal protein 170B 14q32.33 1(0/1/0)
SSTR1 somatostatin receptor 1 14q13 1(1/0/0)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 14q21-q22 1(1/0/0)
TSHR thyroid stimulating hormone receptor 14q24-q31 1(1/0/0)
IGH immunoglobulin heavy locus 14q32.33 1(0/1/0)
CMA1 chymase 1, mast cell 14q12 1(0/0/1)
TDRD9 tudor domain containing 9 14q32.33 3(1/1/1)
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 14q13.3 1(0/0/1)
RBM23 RNA binding motif protein 23 14q11.1 1(0/1/0)
NPAS3 neuronal PAS domain protein 3 14q13.1 2(1/1/0)
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 14q32.31 1(0/1/0)
RAD51B RAD51 paralog B 14q23-q24.2 1(0/1/0)
LRR1 leucine rich repeat protein 1 14q21.3 1(1/0/0)
CGRRF1 cell growth regulator with ring finger domain 1 14q22.2 1(0/1/0)
OTX2 orthodenticle homeobox 2 14q22.3 1(1/0/0)
BDKRB2 bradykinin receptor B2 14q32.1-q32.2 1(1/0/0)
YY1 YY1 transcription factor 14q 1(0/1/0)
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 14q32.13 1(1/0/0)
SIVA1 SIVA1, apoptosis-inducing factor 14q32.33 1(0/1/0)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 14q32.33 1(1/0/0)
SNORD114-7 small nucleolar RNA, C/D box 114-7 14q32.31 1(0/1/0)
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 14q11.2 1(0/1/0)

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